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A7J3A3

- VP2_ROTYO

UniProt

A7J3A3 - VP2_ROTYO

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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain Human/Japan/YO/1977 G3-P1A[8]-I1-R1-C1-M1-Ax-Nx-Tx-E1-Hx) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus A (strain Human/Japan/YO/1977 G3-P1A[8]-I1-R1-C1-M1-Ax-Nx-Tx-E1-Hx) (RV-A)
Taxonomic identifieri578832 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion Curated
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Inner capsid protein VP2PRO_0000368059Add
BLAST

Interactioni

Subunit structurei

Dimer (Potential). Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 (By similarity).By similarityCurated

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 100100Interaction with VP1 and VP3By similarityAdd
BLAST
Regioni404 – 42421HydrophobicBy similarityAdd
BLAST
Regioni432 – 45221HydrophobicBy similarityAdd
BLAST
Regioni546 – 56722Leucine-zipper 1Sequence AnalysisAdd
BLAST
Regioni675 – 69622Leucine-zipper 2Sequence AnalysisAdd
BLAST

Domaini

The N-terminus is involved in VP1 binding.By similarity

Sequence similaritiesi

Belongs to the rotavirus VP2 family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

A7J3A3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYRKRGVKR ENLPQQHERL QEKEIENNTD VTMENKNNNR KQQLSDKVLS
60 70 80 90 100
QKEEIITDVQ DDIKIADEVK KSSKEESKQL LEILKTKEDH QKEVQYEILQ
110 120 130 140 150
KTIPTFEPKE SILKKLEDIR PEQAKKQMKL FRIFEPRQLP IYRTNGEKEL
160 170 180 190 200
RNRWYWKLKK DTLPDGDYDV REYFLNLYDQ ILIEMPDYLL LKDMAVENKN
210 220 230 240 250
SRDAGKVVDS ETANICDAIF QDEETEGVIR RFIADMRQQV QADRNIVNYP
260 270 280 290 300
SILHPIDHAF NEYFLNHQLV EPLNNEIIFN YIPERIRNDV NYILNMDMNL
310 320 330 340 350
PSTARYIRPN LLQDRLNLHD NFESLWDTIT TSNYILARSV VPDLKEKELV
360 370 380 390 400
STEAQIQKMS QDLQLEALTI QSETQFLAGI NSQAANDCFK TLIAAMLSQR
410 420 430 440 450
TMSLDFVTTN YMSLISGMWL LTVIPNDMFL RESLVACELA IINTIVYPAF
460 470 480 490 500
GMQRMHYRNG DPQTPFQIAE QQIQNFQVAN WLHFINNNRF RQVVIDGVLN
510 520 530 540 550
QTLNDNIRNG QVINQLMEAL MQLSRQQFPT MPVDYKRSIQ RGILLLSNRL
560 570 580 590 600
GQLVDLTRLV SYNYETLMAC ITMNMQHVQT LTTEKLQLTS VTSLCMLIGN
610 620 630 640 650
TTVIPSPQTL FHYYNVNVNF HSNYNERIND AVAIITAANR LNLYQKKMKS
660 670 680 690 700
IVEDFLKRLQ IFDVPRVPDD QMYRLRDRLR LLPVERRRLD IFNLILMNME
710 720 730 740 750
QIERASDKIA QGVIIAYRDM QLERDEMYGF VNIARNLDGY QQINLEELMR
760 770 780 790 800
TGDYGQITNM LLNNQPVALV GALPFVTDSS VISLIAKLDA TVFAQIVKLR
810 820 830 840 850
KVDTLKPILY KINSDSNDFY LVANYDWIPT STTKVYKQVP QPFDFRASMH
860 870 880 890
MLTSNLTFTV YSDLLSFVSA DTVEPINAIA FDNMRIMNEL
Length:890
Mass (Da):103,927
Last modified:September 11, 2007 - v1
Checksum:iEEAA4BD3C1586DC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ870498 Genomic RNA. Translation: ABI60853.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ870498 Genomic RNA. Translation: ABI60853.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
    Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
    J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTYO
AccessioniPrimary (citable) accession number: A7J3A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 11, 2007
Last modified: October 1, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3