Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A7J391

- VP2_ROTHS

UniProt

A7J391 - VP2_ROTHS

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain Human/Japan/S2/1980 G2-P1B[4]-I2-R2-C2-M2-Ax-Nx-T2-E2-Hx) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus A (strain Human/Japan/S2/1980 G2-P1B[4]-I2-R2-C2-M2-Ax-Nx-T2-E2-Hx) (RV-A)
    Taxonomic identifieri10959 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW
    2. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 879879Inner capsid protein VP2PRO_0000368058Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9191Interaction with VP1 and VP3By similarityAdd
    BLAST
    Regioni393 – 41321HydrophobicBy similarityAdd
    BLAST
    Regioni421 – 44121HydrophobicBy similarityAdd
    BLAST
    Regioni535 – 55622Leucine-zipper 1Sequence AnalysisAdd
    BLAST
    Regioni664 – 68522Leucine-zipper 2Sequence AnalysisAdd
    BLAST

    Domaini

    The N-terminus is involved in VP1 binding.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR007779. Rotavirus_VP2.
    [Graphical view]
    PfamiPF05087. Rota_VP2. 1 hit.
    [Graphical view]
    ProDomiPD008866. Rota_VP2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    A7J391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYRKRGARR EANLNNNDRM QEKNDEKQDS NKIQLSDKVL SKKEEVVTDS    50
    HEEVKITDEV KKSTKEESKQ LLEVLKTKEE HQKEIQYEIL QKTIPTFEPK 100
    ETILRKLEDI KPELAKKQTK LFRIFEPKQL PIYRANGERE LRNRWYWKLK 150
    KDTLPDGDYD VREYFLNLYD QVLTEMPDYL LLKDMAVENK NSRDAGKVVD 200
    SETASICDAI FQDEETEGAV RRFIAEMRQR VQADRNVVNY PSILHPIDYA 250
    FNEYFLQHQL VEPLNNDIIF NYIPERIRND VNYILNMDRN LPSTARYIRP 300
    NLLQDRLNLH DNFESLWDTI TTSNYILARS VVPDLKELVS TEAQIQKMSQ 350
    DLQLEALTIQ SETQFLTGIN SQAANDCFKT LIAAMLSQRT MSLDFVTTNY 400
    MSLISGMWLL TVVPNDMFIR ESLVACQLAI VNTIIYPAFG MQRMHYRNGD 450
    PQTPFQIAEQ QIQNFQVANW LHFVNNNQFR QAVIDGVLNQ VLNDNIRNGH 500
    VINQLMEALM QLSRQQFPTM PVDYKRSIQR GILLLSNRLG QLVDLTRLLA 550
    YNYETLMACI TMNMQHVQTL TTEKLQLTSV TSLCMLIGNA TVIPSPQTLF 600
    HYYNVNVNFH SNYNERINDA VAIITAANRL NLYQKKMKAI VEDFLKRLYI 650
    FDVSRVPDDQ MYRLRDRLRL LPVEIRRLDI FNLILMNMDQ IERASDKIAQ 700
    GVIIAYRDMH LERDEMYGYV NIARNLEGFQ QINLEELMRS GDYAQITNML 750
    LNNQPVALVG ALPFITDSSV ISLIAKLDAT VFAQIVKLRK VDTLKPILYK 800
    INSDSNDFYL VANYDWVPTS TTKVYKQVPQ QFDFRNSMHM LTSNLTFTVY 850
    SDLLAFVSAD TVEPINAVAF DNMRIMNEL 879
    Length:879
    Mass (Da):102,398
    Last modified:September 11, 2007 - v1
    Checksum:iD2BA3E351480F151
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ870486 Genomic RNA. Translation: ABI60845.1.
    DQ490203 Genomic RNA. Translation: ABF57055.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ870486 Genomic RNA. Translation: ABI60845.1 .
    DQ490203 Genomic RNA. Translation: ABF57055.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007779. Rotavirus_VP2.
    [Graphical view ]
    Pfami PF05087. Rota_VP2. 1 hit.
    [Graphical view ]
    ProDomi PD008866. Rota_VP2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
      Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
      J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 148-316.

    Entry informationi

    Entry nameiVP2_ROTHS
    AccessioniPrimary (citable) accession number: A7J391
    Secondary accession number(s): Q0Q7L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3