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A7J391

- VP2_ROTHS

UniProt

A7J391 - VP2_ROTHS

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Protein
Inner capsid protein VP2
Gene
N/A
Organism
Rotavirus A (strain Human/Japan/S2/1980 G2-P1B[4]-I2-R2-C2-M2-Ax-Nx-T2-E2-Hx) (RV-A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus A (strain Human/Japan/S2/1980 G2-P1B[4]-I2-R2-C2-M2-Ax-Nx-T2-E2-Hx) (RV-A)
Taxonomic identifieri10959 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879Inner capsid protein VP2
PRO_0000368058Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9191Interaction with VP1 and VP3 By similarity
Add
BLAST
Regioni393 – 41321Hydrophobic By similarity
Add
BLAST
Regioni421 – 44121Hydrophobic By similarity
Add
BLAST
Regioni535 – 55622Leucine-zipper 1 Reviewed prediction
Add
BLAST
Regioni664 – 68522Leucine-zipper 2 Reviewed prediction
Add
BLAST

Domaini

The N-terminus is involved in VP1 binding By similarity.

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

A7J391-1 [UniParc]FASTAAdd to Basket

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MAYRKRGARR EANLNNNDRM QEKNDEKQDS NKIQLSDKVL SKKEEVVTDS    50
HEEVKITDEV KKSTKEESKQ LLEVLKTKEE HQKEIQYEIL QKTIPTFEPK 100
ETILRKLEDI KPELAKKQTK LFRIFEPKQL PIYRANGERE LRNRWYWKLK 150
KDTLPDGDYD VREYFLNLYD QVLTEMPDYL LLKDMAVENK NSRDAGKVVD 200
SETASICDAI FQDEETEGAV RRFIAEMRQR VQADRNVVNY PSILHPIDYA 250
FNEYFLQHQL VEPLNNDIIF NYIPERIRND VNYILNMDRN LPSTARYIRP 300
NLLQDRLNLH DNFESLWDTI TTSNYILARS VVPDLKELVS TEAQIQKMSQ 350
DLQLEALTIQ SETQFLTGIN SQAANDCFKT LIAAMLSQRT MSLDFVTTNY 400
MSLISGMWLL TVVPNDMFIR ESLVACQLAI VNTIIYPAFG MQRMHYRNGD 450
PQTPFQIAEQ QIQNFQVANW LHFVNNNQFR QAVIDGVLNQ VLNDNIRNGH 500
VINQLMEALM QLSRQQFPTM PVDYKRSIQR GILLLSNRLG QLVDLTRLLA 550
YNYETLMACI TMNMQHVQTL TTEKLQLTSV TSLCMLIGNA TVIPSPQTLF 600
HYYNVNVNFH SNYNERINDA VAIITAANRL NLYQKKMKAI VEDFLKRLYI 650
FDVSRVPDDQ MYRLRDRLRL LPVEIRRLDI FNLILMNMDQ IERASDKIAQ 700
GVIIAYRDMH LERDEMYGYV NIARNLEGFQ QINLEELMRS GDYAQITNML 750
LNNQPVALVG ALPFITDSSV ISLIAKLDAT VFAQIVKLRK VDTLKPILYK 800
INSDSNDFYL VANYDWVPTS TTKVYKQVPQ QFDFRNSMHM LTSNLTFTVY 850
SDLLAFVSAD TVEPINAVAF DNMRIMNEL 879
Length:879
Mass (Da):102,398
Last modified:September 11, 2007 - v1
Checksum:iD2BA3E351480F151
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ870486 Genomic RNA. Translation: ABI60845.1.
DQ490203 Genomic RNA. Translation: ABF57055.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ870486 Genomic RNA. Translation: ABI60845.1 .
DQ490203 Genomic RNA. Translation: ABF57055.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains."
    Matthijnssens J., Ciarlet M., Heiman E.M., Arijs I., Delbeke T., McDonald S.M., Palombo E.A., Iturriza-Gomara M., Maes P., Patton J.T., Rahman M., Van Ranst M.
    J. Virol. 82:3204-3219(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 148-316.

Entry informationi

Entry nameiVP2_ROTHS
AccessioniPrimary (citable) accession number: A7J391
Secondary accession number(s): Q0Q7L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 11, 2007
Last modified: October 16, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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