Reviewed, UniProtKB/Swiss-Prot A7J1T2 (M313A_XENLA)

Names and origin

Protein names

Recommended name:
    Mitogen-activated protein kinase kinase kinase 13-A
    EC=2.7.11.25

Gene names

Name:

map3k13-A

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	961 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May have a role in the JNK signaling pathway By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Domain	Coiled coil Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	protein amino acid autophosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase kinase kinase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro protein homodimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 961	961	Mitogen-activated protein kinase kinase kinase 13-A		PRO_0000366129
Regions
	Domain	169 – 410	242	Protein kinase
	Domain	434 – 455	22	Leucine-zipper 1 Potential
	Domain	487 – 508	22	Leucine-zipper 2 Potential
	Nucleotide binding	175 – 183	9	ATP By similarity
	Region	811 – 824	14	Acidic By similarity
	Coiled coil	458 – 497	40	Potential
	Compositional bias	813 – 818	6	Poly-Glu
Sites
	Active site	280	1	Proton acceptor By similarity
	Binding site	196	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7J1T2-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: BD4F6FE290D4272B	FASTA	961	107,185
	10 20 30 40 50 60 MHLNDTMASP LEPLSWSSSP NLIVDTLRED KDYRVNYGDC TTIGHHEIKE TPDKCDSLDN 70 80 90 100 110 120 ANSPVTATVL TSISEDSRDQ FENSVLQLRD QDEPENTAPQ GSSHSGDGGS YSGNEDIRIH 130 140 150 160 170 180 FGHSGSGNSG FLEGLFGCLR PVWNIIGKAY STDYKLQQQE TWEVPFEEIS ELQWLGSGAQ 190 200 210 220 230 240 GAVFLGKFRG EEVAIKKVRE QKETDIKHLR KLKHPNIIAF KGVCTQAPCY CLIMEYCAHG 250 260 270 280 290 300 QLYEVLRAGR KVSPRLLVDW SNGIASGMNY LHLHKIIHRD LKSPNVLVTH TDTVKISDFG 310 320 330 340 350 360 TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVLLWELLTG EIPYKDVDSS 370 380 390 400 410 420 AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WHSKPRNRPS FRQILMHLDI ASADVLGTPQ 430 440 450 460 470 480 ETYFKSQAEW REEVKKHFEK IKSEGTCIHR LDEELIRRRR EELRHALDIR EHYERKLERA 490 500 510 520 530 540 NNLYMELSAI MLQLEVREKE LIRREQAVEK KYPGTYKRHP VRPIVHPNSV EKLIKKKGPP 550 560 570 580 590 600 SRIPSQTKRP DLLKSDGIVS AEGSAASASP ISGSPKTSSG GGKNRYRSKP RHRRVNSKGS 610 620 630 640 650 660 HADFIGVLKH LESPALSQQS SQHQTLASPP VTSCSPYHET SQVMPTFHQT LNVHGQNIAN 670 680 690 700 710 720 CANNLRYFGP AAALRSPLSS HAQRRMSGSS PDLLSSTLEA DSHIQPEREY EYCQQDPYNR 730 740 750 760 770 780 CPGCTEAVQQ DTDTGNWDST NVVTAEYRTS GGDPPESPRH NLVQENNEKL ESGGEQFSSF 790 800 810 820 830 840 KAAIGVSALT VPTPPALPRR IRTLRKNGDE SSEEEEGEVD SEVEFPRRHR PPRGMSKCQS 850 860 870 880 890 900 YSTFSSENFS VSDGEEGNTS DHSNSPDDVA GGGKVWHGDK LDDLSQTPEI PIEISMQSDG 910 920 930 940 950 960 LSDKECAVRR VKTQMSLGKL CTEEHNYENA GNFAESDCDS SEGECSDATV LTNNPVNSST W

References

[1]	Itoh A., Ryan K., Itoh T. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: xLZK-A_20115.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ862006 mRNA. Translation: ABK15544.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR017419. MAP3K12_MAP3K13. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR001245. Tyr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PIRSF	PIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

M313A_XENLA

Accession

Primary (citable) accession number: A7J1T2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	September 11, 2007
Last modified:	October 13, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project