A7J1T0 (M313B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitogen-activated protein kinase kinase kinase 13-B
EC=2.7.11.25

Gene names

Name:

map3k13-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	961 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have a role in the JNK signaling pathway By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Domain	Coiled coil Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	protein autophosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase kinase kinase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro protein homodimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 961	961	Mitogen-activated protein kinase kinase kinase 13-B		PRO_0000366130
Regions
	Domain	171 – 412	242	Protein kinase
	Domain	436 – 457	22	Leucine-zipper 1
	Domain	489 – 510	22	Leucine-zipper 2
	Nucleotide binding	177 – 185	9	ATP By similarity
	Region	814 – 827	14	Acidic By similarity
	Coiled coil	460 – 497	38	Potential
Sites
	Active site	282	1	Proton acceptor By similarity
	Binding site	198	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7J1T0 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: CD82B672163A4AB5	FASTA	961	107,570
	10 20 30 40 50 60 MHLNDIMASP HEPLNWSSSP NLIVDTIQED KDYRVDYGDC TTIGHHEIKE TPDKCDFLDN 70 80 90 100 110 120 TNSPVNATVL NSISEDSRDQ FENSVLQLRD QDEPENTAPQ GSSHSGDGGN NSANEDIRIH 130 140 150 160 170 180 FSRSRSGSGN GGFLEGLFGC LRPVWNIIGK AYSTDYKLQQ QDTWEVPFEE ISELQWLGSG 190 200 210 220 230 240 AQGAVFLGKF RGEEVAIKKV REQKETDIKH LRKLKHPNII AFKGVCTQAP CYCILMEYCA 250 260 270 280 290 300 QGQLYEVLRA GRKVTPKLLV EWSTGIASGM NYLHLHKIIH RDLKSPNVLV THADTVKISD 310 320 330 340 350 360 FGTSKELSDK STKMSFAGTV AWMAPEVIRN EPVSEKVDIW SFGVLLWELL TGEIPYKDVD 370 380 390 400 410 420 SSAIIWGVGS NSLHLPVPST CPDGFKILMK QTWQSKPRNR PSFRQILMHL DIAAADVLGT 430 440 450 460 470 480 PQETYFKSQA EWREEVKKHF EKIKSEGTCI HRLDEELIRR RREELRHALD IREHYERKLE 490 500 510 520 530 540 RANNLYMELS SIMLQLEVRE KELTRREQTV EKKYPGTYKR HPVRPIVHPN SFEKLIKKKG 550 560 570 580 590 600 PPSRVPSQSK RPDLLKSDGI VNAEGSAASA SPISGSPKTS SGGGKGRYRS KPRHRRGNSK 610 620 630 640 650 660 GSHADFVGVL KYQESPAPSQ QSSQHQTPAS PPVTPCSPYH ETSQVMPTRH QTLNVHGQNI 670 680 690 700 710 720 ANCANNLRYF GPAAALRSPL SSHAHRRMSG FSPDLLSSTL EADSRIQPER EYEYCEQHPY 730 740 750 760 770 780 NPSQGCTETS VQHDIDTENL NNTNVVTAEY RTSDGDLPDS PRHNLVQEDY EKLETGGEQF 790 800 810 820 830 840 SSLKAAVGVS ALTVPTPPAL PRRIHTLRKN GDDSSEGEEG EVDSEVEFPR RHRPPRGMST 850 860 870 880 890 900 CQSYSTFSSE NFSVSDGEEG NTSDHSNSPD DVACGNKVWQ VDKLDDLLSQ TPEIPIEISM 910 920 930 940 950 960 QSDGLSDKEC AVRRVKTQMS LGKLCPEEHN YENAESDCDS SEGECSDATV RTNNPVNSST W

References

[1]	Itoh A., Ryan K., Itoh T. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: xLZK-B_20703.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ862004 mRNA. Translation: ABK15542.1.
RefSeq	NP_001165659.1. NM_001172188.1.
UniGene	Xl.83243.
3D structure databases
ProteinModelPortal	A7J1T0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100337577.
KEGG	xla:100337577.
Organism-specific databases
CTD	100337577.
Xenbase	XB-GENE-6464340. map3k13.
Phylogenomic databases
HOVERGEN	HBG052383.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR017419. MAP3K12_MAP3K13. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
KO	K04422.
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PIRSF	PIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
PRINTS	PR00109. TYRKINASE.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

M313B_XENLA

Accession

Primary (citable) accession number: A7J1T0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	September 11, 2007
Last modified:	November 16, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program