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A7J1T0 (M313B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase kinase kinase 13-B
EC=2.7.11.25
Gene names
Name:map3k13-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length961 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a role in the JNK signaling pathway By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   DomainCoiled coil
Repeat
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: GOC

protein autophosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase kinase kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 961961Mitogen-activated protein kinase kinase kinase 13-B
PRO_0000366130

Regions

Domain171 – 412242Protein kinase
Nucleotide binding177 – 1859ATP By similarity
Region436 – 45722Leucine-zipper 1
Region489 – 51022Leucine-zipper 2
Region814 – 82714Acidic By similarity
Coiled coil460 – 49738 Potential

Sites

Active site2821Proton acceptor By similarity
Binding site1981ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7J1T0 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: CD82B672163A4AB5

FASTA961107,570
        10         20         30         40         50         60 
MHLNDIMASP HEPLNWSSSP NLIVDTIQED KDYRVDYGDC TTIGHHEIKE TPDKCDFLDN 

        70         80         90        100        110        120 
TNSPVNATVL NSISEDSRDQ FENSVLQLRD QDEPENTAPQ GSSHSGDGGN NSANEDIRIH 

       130        140        150        160        170        180 
FSRSRSGSGN GGFLEGLFGC LRPVWNIIGK AYSTDYKLQQ QDTWEVPFEE ISELQWLGSG 

       190        200        210        220        230        240 
AQGAVFLGKF RGEEVAIKKV REQKETDIKH LRKLKHPNII AFKGVCTQAP CYCILMEYCA 

       250        260        270        280        290        300 
QGQLYEVLRA GRKVTPKLLV EWSTGIASGM NYLHLHKIIH RDLKSPNVLV THADTVKISD 

       310        320        330        340        350        360 
FGTSKELSDK STKMSFAGTV AWMAPEVIRN EPVSEKVDIW SFGVLLWELL TGEIPYKDVD 

       370        380        390        400        410        420 
SSAIIWGVGS NSLHLPVPST CPDGFKILMK QTWQSKPRNR PSFRQILMHL DIAAADVLGT 

       430        440        450        460        470        480 
PQETYFKSQA EWREEVKKHF EKIKSEGTCI HRLDEELIRR RREELRHALD IREHYERKLE 

       490        500        510        520        530        540 
RANNLYMELS SIMLQLEVRE KELTRREQTV EKKYPGTYKR HPVRPIVHPN SFEKLIKKKG 

       550        560        570        580        590        600 
PPSRVPSQSK RPDLLKSDGI VNAEGSAASA SPISGSPKTS SGGGKGRYRS KPRHRRGNSK 

       610        620        630        640        650        660 
GSHADFVGVL KYQESPAPSQ QSSQHQTPAS PPVTPCSPYH ETSQVMPTRH QTLNVHGQNI 

       670        680        690        700        710        720 
ANCANNLRYF GPAAALRSPL SSHAHRRMSG FSPDLLSSTL EADSRIQPER EYEYCEQHPY 

       730        740        750        760        770        780 
NPSQGCTETS VQHDIDTENL NNTNVVTAEY RTSDGDLPDS PRHNLVQEDY EKLETGGEQF 

       790        800        810        820        830        840 
SSLKAAVGVS ALTVPTPPAL PRRIHTLRKN GDDSSEGEEG EVDSEVEFPR RHRPPRGMST 

       850        860        870        880        890        900 
CQSYSTFSSE NFSVSDGEEG NTSDHSNSPD DVACGNKVWQ VDKLDDLLSQ TPEIPIEISM 

       910        920        930        940        950        960 
QSDGLSDKEC AVRRVKTQMS LGKLCPEEHN YENAESDCDS SEGECSDATV RTNNPVNSST 


W

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References

[1]Itoh A., Ryan K., Itoh T.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: xLZK-B_20703.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ862004 mRNA. Translation: ABK15542.1.
RefSeqNP_001165659.1. NM_001172188.1.
UniGeneXl.83243.

3D structure databases

ProteinModelPortalA7J1T0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100337577.
KEGGxla:100337577.

Organism-specific databases

CTD100337577.
XenbaseXB-GENE-6464340. map3k13.

Phylogenomic databases

HOVERGENHBG052383.
KOK04422.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR017419. MAP3K12_MAP3K13.
IPR000719. Prot_kinase_cat_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. False negative.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameM313B_XENLA
AccessionPrimary (citable) accession number: A7J1T0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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