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Protein

Ribonucleoside-diphosphate reductase

Gene

B832R

Organism
Paramecium bursaria Chlorella virus NY2A (PBCV-NY2A)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processDNA replicationUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:B832RImported
ORF Names:NY2A_B832RImported
OrganismiParamecium bursaria Chlorella virus NY2A (PBCV-NY2A)Imported
Taxonomic identifieri46021 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePhycodnaviridaeChlorovirus
Virus hostiChlorella [TaxID: 114049]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 113ATP-coneInterPro annotationAdd BLAST104
Domaini626 – 669DOD-type homing endonucleaseInterPro annotationAdd BLAST44

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Phylogenomic databases

KOiK10807.

Family and domain databases

Gene3Di2.170.16.10. 2 hits.
3.10.28.10. 1 hit.
InterProiView protein in InterPro
IPR005144. ATP-cone_dom.
IPR028992. Hedgehog/Intein_dom.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_N.
IPR004860. LAGLIDADG_2.
IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
PfamiView protein in Pfam
PF03477. ATP-cone. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PRINTSiPR00379. INTEIN.
SMARTiView protein in SMART
SM00306. HintN. 1 hit.
SUPFAMiSSF48168. SSF48168. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF55608. SSF55608. 1 hit.
TIGRFAMsiTIGR01445. intein_Nterm. 1 hit.
TIGR02506. NrdE_NrdA. 1 hit.
PROSITEiView protein in PROSITE
PS51161. ATP_CONE. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
PS00089. RIBORED_LARGE. 1 hit.

Sequencei

Sequence statusi: Complete.

A7IY07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRPMNRLM VVLKRDGSKE NISFDKILQR IQRLCWPINS KPVYKGSRAM
60 70 80 90 100
TGLSVDVSKI VASVCASIVD GISTVQLDEL TADKSASMTT EHPDYGILAA
110 120 130 140 150
RISVSNLQKQ THDKITDAYA EIAHLLSNDF KENIEKHADE YQSFIDYDRD
160 170 180 190 200
YDFDYFGFKT MERLYLTKVN NKIVERPQHV YLRVAIGLWG SDIARVKETY
210 220 230 240 250
DALSCRKFTH ASPTLFNAGF KKAQLASCFL VTVEDSLGDI YKVLGDCAQL
260 270 280 290 300
SKHGGGLGIN ISEIRGRGSR INGTNGESDG IVPMLKVFDT TSAYANQGGR
310 320 330 340 350
RKGSFAIYLE PHHSDVMDFL LMKRNQGEES LRARNLFYAV WLNDLFMKRV
360 370 380 390 400
ETDAQWSLFD PSECPGLTDA FGDEYAELYE RYEAEGKAKN VVKARDVWNT
410 420 430 440 450
MVTTIIETGQ PYVSNKDAVN KKNMQMNAGT IRGSNLCVAG DTKILTSSGY
460 470 480 490 500
HPIKDMEGKQ VRVWNGYEFS ETIVHKTGVN QKLIMVSLDD GTELRCTPYH
510 520 530 540 550
KFYIETGSRP ADKSRVMEVR AGDLEKGDRI IRFELPTITV GETTMSDKEA
560 570 580 590 600
YTKGFFSADG CVIKSKYGED EYRISVKRED KIEALTKYVD VIKSHTNRFR
610 620 630 640 650
THFYVPDYVQ NKFEVPINSM VNEKISWLAG FMDGDGCVIR YKDIENMQAV
660 670 680 690 700
SINKSFLQDI RLMLQTIGIH STINKFMPNR VMKMPDGRGG TDMYNGAESW
710 720 730 740 750
RLQIDSEGVR KLFALGFTPR RLKMNGSRKR HHKTNKFTRV VSVTDHGDVE
760 770 780 790 800
DTYCFNEPKR HMGVFNGVIT GQCNEIVEYT SKEETAVCVI GSVVLKNYVK
810 820 830 840 850
NDKFDFDDLR KNVKILAKNL DRSIDVMAYP IKEAETSNKL RRPIGVGVQG
860 870 880 890 900
LQDVFFKLRF SYDSPEARDL NREIFEHIYY AAVEASVELA EIHGPYPTFE
910 920 930 940 950
GSPASKGILQ YHLWDVTPKS NLDWRGLEER VKKGIRNSLV TALMPTASTA
960 970 980 990 1000
QICGSVEAFE PITSNLYSRR TLAGEFPVIN SYLVRELIER GTWNEQMKNQ
1010 1020 1030 1040 1050
IIANGGSIQK VIGIHPSVKA VYKTAWDLSM KSVIDMASDR GAFVDQTQSM
1060 1070 1080 1090 1100
NLFLAQPTLK NVTSMLFYGW KSGLKTLQYY LRSKPASSAI AVTIDNDCLV

CSA
Length:1,103
Mass (Da):124,555
Last modified:September 11, 2007 - v1
Checksum:i3DE8471A1F22FA82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ491002 Genomic DNA. Translation: ABT15231.1.
RefSeqiYP_001498028.1. NC_009898.1.

Genome annotation databases

GeneIDi5659402.
KEGGivg:5659402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ491002 Genomic DNA. Translation: ABT15231.1.
RefSeqiYP_001498028.1. NC_009898.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5659402.
KEGGivg:5659402.

Phylogenomic databases

KOiK10807.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

Gene3Di2.170.16.10. 2 hits.
3.10.28.10. 1 hit.
InterProiView protein in InterPro
IPR005144. ATP-cone_dom.
IPR028992. Hedgehog/Intein_dom.
IPR003587. Hint_dom_N.
IPR027434. Homing_endonucl.
IPR006142. INTEIN.
IPR004042. Intein_endonuc.
IPR006141. Intein_N.
IPR004860. LAGLIDADG_2.
IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
PfamiView protein in Pfam
PF03477. ATP-cone. 1 hit.
PF14528. LAGLIDADG_3. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PRINTSiPR00379. INTEIN.
SMARTiView protein in SMART
SM00306. HintN. 1 hit.
SUPFAMiSSF48168. SSF48168. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF55608. SSF55608. 1 hit.
TIGRFAMsiTIGR01445. intein_Nterm. 1 hit.
TIGR02506. NrdE_NrdA. 1 hit.
PROSITEiView protein in PROSITE
PS51161. ATP_CONE. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
PS00089. RIBORED_LARGE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA7IY07_PBCVN
AccessioniPrimary (citable) accession number: A7IY07
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 6, 2016
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.