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Protein
Submitted name:

Chemokine receptor CXCR6

Gene

Cxcr6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine receptor CXCR6Imported
Submitted name:
Protein Cxcr6Imported
Gene namesi
Name:Cxcr6Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1642118. Cxcr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6626HelicalSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Transmembranei118 – 14326HelicalSequence analysisAdd
BLAST
Transmembranei155 – 17824HelicalSequence analysisAdd
BLAST
Transmembranei198 – 22023HelicalSequence analysisAdd
BLAST
Transmembranei241 – 26525HelicalSequence analysisAdd
BLAST
Transmembranei277 – 30226HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000006319.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008294.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 297241G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG091G0D3V.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ISD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDGHQEKDL DDDVYGGDPW LFNNSSGNSQ EHKRFLKFKE VFLPCMYLVV
60 70 80 90 100
FVLGLLGNSL VLIIYIFYQR LRSLTDVFLL NLPLADLVFV CTLPFWAYAG
110 120 130 140 150
TYEWVFGTAM CKTLRSMYAM NFYVSMLTLT CITVDRFVVV VQATKAFNRQ
160 170 180 190 200
AKWKIWGQVT CLLIWVVSLL VSLPQIIYSR VGHIDRLICQ FHNEAISTVV
210 220 230 240 250
LVLQMTLGFF LPLLTMILCY SGIIKTLLHA RNFQKHKSLK IIFLVVATFL
260 270 280 290 300
LTQTPFNIAM LIQWISWEYS TITSFQYVVL VTEAIAYLRA CLNPVLYAFV
310 320 330 340 350
GLKFRKNLWK LMKDISCLSR LGVSSQWKSS EDNSKTCSAS HNAETTSMFQ

L
Length:351
Mass (Da):40,368
Last modified:September 11, 2007 - v1
Checksum:i03585D6CE933E7F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07071820 Genomic DNA. No translation available.
DQ132631 mRNA. Translation: AAZ66333.1.
RefSeqiNP_001096057.1. NM_001102587.1.
UniGeneiRn.217921.

Genome annotation databases

EnsembliENSRNOT00000008294; ENSRNOP00000008294; ENSRNOG00000006319.
GeneIDi100124593.
KEGGirno:100124593.
UCSCiRGD:1642118. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07071820 Genomic DNA. No translation available.
DQ132631 mRNA. Translation: AAZ66333.1.
RefSeqiNP_001096057.1. NM_001102587.1.
UniGeneiRn.217921.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008294.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008294; ENSRNOP00000008294; ENSRNOG00000006319.
GeneIDi100124593.
KEGGirno:100124593.
UCSCiRGD:1642118. rat.

Organism-specific databases

CTDi10663.
RGDi1642118. Cxcr6.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG091G0D3V.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSRNOG00000006319.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA7ISD5_RAT
AccessioniPrimary (citable) accession number: A7ISD5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.