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A7IQH5

- A7IQH5_XANP2

UniProt

A7IQH5 - A7IQH5_XANP2

Protein
Submitted name:

Short-chain dehydrogenase/reductase SDR

Gene

Xaut_5073

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei19 – 191NAD; via amide nitrogenImported
    Binding sitei91 – 911NAD; via carbonyl oxygenImported
    Binding sitei143 – 1431Acetate
    Binding sitei156 – 1561Acetate
    Binding sitei156 – 1561NADImported
    Binding sitei160 – 1601NADImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 392NADImported
    Nucleotide bindingi64 – 652NADImported
    Nucleotide bindingi186 – 1949NADImported

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. oxidoreductase activity Source: InterPro

    Keywords - Ligandi

    NADImported, Nucleotide-bindingImported

    Enzyme and pathway databases

    BioCyciXAUT78245:GHS6-5131-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Short-chain dehydrogenase/reductase SDRImported
    Gene namesi
    Ordered Locus Names:Xaut_5073Imported
    Encoded oniPlasmid pXAUT01Imported
    OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)Imported
    Taxonomic identifieri78245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
    ProteomesiUP000002417: Plasmid pXAUT01

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525 PotentialImportedAdd
    BLAST
    Chaini26 – 255230 PotentialImportedPRO_5000269011Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi78245.Xaut_5073.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GH5X-ray1.60A/B/C/D1-255[»]
    4ITUX-ray1.60A/B/C/D1-255[»]
    ProteinModelPortaliA7IQH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiCOG1028.
    OMAiGMETNIS.
    OrthoDBiEOG6N3CR8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7IQH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNRLKNEVI AITGGGAGIG LAIASAALRE GAKVALIDLD QGLAERSAAM    50
    LSTGGAVAKG FGADVTKAAD ITAAITSAEQ TIGSLTGLVN NAGIAGFGSV 100
    HDADAAAWDR IMAVNVTGTF LASKAALAGM LERHKGTIVN FGSVAGLVGI 150
    PTMAAYCAAK GAIVNLTRQM AADYSGRGVR VNAVCPGTVT STGMGQQLLG 200
    SDTSPEVQAR RLAKYPIGRF GTPEDIAEAV IFLLSDQAAF VTGAAFAVDG 250
    GMTAI 255
    Length:255
    Mass (Da):25,473
    Last modified:September 11, 2007 - v1
    Checksum:i12E8F086584059B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000782 Genomic DNA. Translation: ABS70271.1.
    RefSeqiYP_001409507.1. NC_009717.1.

    Genome annotation databases

    EnsemblBacteriaiABS70271; ABS70271; Xaut_5073.
    GeneIDi5420366.
    KEGGixau:Xaut_5073.
    PATRICi24041913. VBIXanAut29526_0268.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000782 Genomic DNA. Translation: ABS70271.1 .
    RefSeqi YP_001409507.1. NC_009717.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GH5 X-ray 1.60 A/B/C/D 1-255 [» ]
    4ITU X-ray 1.60 A/B/C/D 1-255 [» ]
    ProteinModelPortali A7IQH5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 78245.Xaut_5073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS70271 ; ABS70271 ; Xaut_5073 .
    GeneIDi 5420366.
    KEGGi xau:Xaut_5073.
    PATRICi 24041913. VBIXanAut29526_0268.

    Phylogenomic databases

    eggNOGi COG1028.
    OMAi GMETNIS.
    OrthoDBi EOG6N3CR8.

    Enzyme and pathway databases

    BioCyci XAUT78245:GHS6-5131-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Crystal structures of S-HPCDH reveal determinants of stereospecificity for R- and S-hydroxypropyl-coenzyme M dehydrogenases."
      Bakelar J.W., Sliwa D.A., Johnson S.J.
      Arch. Biochem. Biophys. 533:62-68(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH NAD.

    Entry informationi

    Entry nameiA7IQH5_XANP2
    AccessioniPrimary (citable) accession number: A7IQH5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, PlasmidImported, Reference proteomeImported

    External Data

    Dasty 3