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A7IQH5

- A7IQH5_XANP2

UniProt

A7IQH5 - A7IQH5_XANP2

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Protein
Submitted name:

Short-chain dehydrogenase/reductase SDR

Gene

Xaut_5073

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191NAD; via amide nitrogenImported
Binding sitei91 – 911NAD; via carbonyl oxygenImported
Binding sitei143 – 1431Acetate
Binding sitei156 – 1561Acetate
Binding sitei156 – 1561NADImported
Binding sitei160 – 1601NADImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 392NADImported
Nucleotide bindingi64 – 652NADImported
Nucleotide bindingi186 – 1949NADImported

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

NADImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciXAUT78245:GHS6-5131-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Short-chain dehydrogenase/reductase SDRImported
Gene namesi
Ordered Locus Names:Xaut_5073Imported
Encoded oniPlasmid pXAUT01Imported
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)Imported
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
ProteomesiUP000002417: Plasmid pXAUT01

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST
Chaini26 – 255230 PotentialImportedPRO_5000269011Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi78245.Xaut_5073.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GH5X-ray1.60A/B/C/D1-255[»]
4ITUX-ray1.60A/B/C/D1-255[»]
ProteinModelPortaliA7IQH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG1028.
OMAiGMETNIS.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7IQH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNRLKNEVI AITGGGAGIG LAIASAALRE GAKVALIDLD QGLAERSAAM
60 70 80 90 100
LSTGGAVAKG FGADVTKAAD ITAAITSAEQ TIGSLTGLVN NAGIAGFGSV
110 120 130 140 150
HDADAAAWDR IMAVNVTGTF LASKAALAGM LERHKGTIVN FGSVAGLVGI
160 170 180 190 200
PTMAAYCAAK GAIVNLTRQM AADYSGRGVR VNAVCPGTVT STGMGQQLLG
210 220 230 240 250
SDTSPEVQAR RLAKYPIGRF GTPEDIAEAV IFLLSDQAAF VTGAAFAVDG

GMTAI
Length:255
Mass (Da):25,473
Last modified:September 11, 2007 - v1
Checksum:i12E8F086584059B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000782 Genomic DNA. Translation: ABS70271.1.
RefSeqiWP_011993174.1. NC_009717.1.
YP_001409507.1. NC_009717.1.

Genome annotation databases

EnsemblBacteriaiABS70271; ABS70271; Xaut_5073.
GeneIDi5420366.
KEGGixau:Xaut_5073.
PATRICi24041913. VBIXanAut29526_0268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000782 Genomic DNA. Translation: ABS70271.1 .
RefSeqi WP_011993174.1. NC_009717.1.
YP_001409507.1. NC_009717.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GH5 X-ray 1.60 A/B/C/D 1-255 [» ]
4ITU X-ray 1.60 A/B/C/D 1-255 [» ]
ProteinModelPortali A7IQH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 78245.Xaut_5073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS70271 ; ABS70271 ; Xaut_5073 .
GeneIDi 5420366.
KEGGi xau:Xaut_5073.
PATRICi 24041913. VBIXanAut29526_0268.

Phylogenomic databases

eggNOGi COG1028.
OMAi GMETNIS.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

BioCyci XAUT78245:GHS6-5131-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Crystal structures of S-HPCDH reveal determinants of stereospecificity for R- and S-hydroxypropyl-coenzyme M dehydrogenases."
    Bakelar J.W., Sliwa D.A., Johnson S.J.
    Arch. Biochem. Biophys. 533:62-68(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH NAD.

Entry informationi

Entry nameiA7IQH5_XANP2
AccessioniPrimary (citable) accession number: A7IQH5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, PlasmidImported, Reference proteomeImported

External Data

Dasty 3