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Protein
Submitted name:

Short-chain dehydrogenase/reductase SDR

Gene

Xaut_5073

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei19 – 191NAD; via amide nitrogenCombined sources
Binding sitei91 – 911NAD; via carbonyl oxygenCombined sources
Binding sitei156 – 1561NADCombined sources
Binding sitei160 – 1601NADCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 392NADCombined sources
Nucleotide bindingi64 – 652NADCombined sources
Nucleotide bindingi186 – 1949NADCombined sources

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciXAUT78245:GHS6-5131-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Short-chain dehydrogenase/reductase SDRImported
Gene namesi
Ordered Locus Names:Xaut_5073Imported
Encoded oniPlasmid pXAUT01Imported
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)Imported
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
ProteomesiUP000002417: Plasmid pXAUT01

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST
Chaini26 – 255230 PotentialImportedPRO_5000269011Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi78245.Xaut_5073.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GH5X-ray1.60A/B/C/D1-255[»]
4ITUX-ray1.60A/B/C/D1-255[»]
ProteinModelPortaliA7IQH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG1028.
OMAiIGRAVAC.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7IQH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNRLKNEVI AITGGGAGIG LAIASAALRE GAKVALIDLD QGLAERSAAM
60 70 80 90 100
LSTGGAVAKG FGADVTKAAD ITAAITSAEQ TIGSLTGLVN NAGIAGFGSV
110 120 130 140 150
HDADAAAWDR IMAVNVTGTF LASKAALAGM LERHKGTIVN FGSVAGLVGI
160 170 180 190 200
PTMAAYCAAK GAIVNLTRQM AADYSGRGVR VNAVCPGTVT STGMGQQLLG
210 220 230 240 250
SDTSPEVQAR RLAKYPIGRF GTPEDIAEAV IFLLSDQAAF VTGAAFAVDG

GMTAI
Length:255
Mass (Da):25,473
Last modified:September 11, 2007 - v1
Checksum:i12E8F086584059B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000782 Genomic DNA. Translation: ABS70271.1.
RefSeqiWP_011993174.1. NC_009717.1.
YP_001409507.1. NC_009717.1.

Genome annotation databases

EnsemblBacteriaiABS70271; ABS70271; Xaut_5073.
GeneIDi5420366.
KEGGixau:Xaut_5073.
PATRICi24041913. VBIXanAut29526_0268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000782 Genomic DNA. Translation: ABS70271.1.
RefSeqiWP_011993174.1. NC_009717.1.
YP_001409507.1. NC_009717.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GH5X-ray1.60A/B/C/D1-255[»]
4ITUX-ray1.60A/B/C/D1-255[»]
ProteinModelPortaliA7IQH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi78245.Xaut_5073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS70271; ABS70271; Xaut_5073.
GeneIDi5420366.
KEGGixau:Xaut_5073.
PATRICi24041913. VBIXanAut29526_0268.

Phylogenomic databases

eggNOGiCOG1028.
OMAiIGRAVAC.
OrthoDBiEOG6N3CR8.

Enzyme and pathway databases

BioCyciXAUT78245:GHS6-5131-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Crystal structures of S-HPCDH reveal determinants of stereospecificity for R- and S-hydroxypropyl-coenzyme M dehydrogenases."
    Bakelar J.W., Sliwa D.A., Johnson S.J.
    Arch. Biochem. Biophys. 533:62-68(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH NAD.

Entry informationi

Entry nameiA7IQH5_XANP2
AccessioniPrimary (citable) accession number: A7IQH5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, PlasmidImported, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.