A7INQ7 (A7INQ7_XANP2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523
EC=2.3.1.- HAMAP MF_00523

Gene names

Name:	lpxD HAMAP MF_00523
Ordered Locus Names:	Xaut_4430

Organism

Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]

Taxonomic identifier

78245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523 UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. SAAS SAAS020573
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523 Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. SAAS SAAS020573
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily. HAMAP MF_00523

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00523 SAAS SAAS020573 Lipid synthesis
Domain	Repeat HAMAP MF_00523 SAAS SAAS020573
Molecular function	Acyltransferase HAMAP MF_00523 SAAS SAAS020573 EMBL ABS69651.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A7INQ7 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 1E5FEDEA7B7C6E20	FASTA	365	36,785
	10 20 30 40 50 60 MSHDVFFPLP APLTLAEVAA LSGARLAVAD EAQAAELGAR TITGVGTLET AGPDELAFCD 70 80 90 100 110 120 TVQFAEKLGT VRAGAVITAE RFAAKAPPGL VVLIAPRPAA AFLAVTRFLF PGALKPLSIF 130 140 150 160 170 180 GQDGVAPGAQ VHPKARLEDG VTVDPGAVIG PGAEIGAGTI VCAGAIIGPN VRIGRNCAIG 190 200 210 220 230 240 PGASVIHAFL GNGVIIHGGA RIGSDGFGYQ PSPRGHVKVP QIGRVVIQDD VEIGANTTID 250 260 270 280 290 300 RGALTDTVIG EGTKIDNLVQ IAHNVVTGRH CIVVSQTGIS GSTTLGDFVM LGGQVGVVGH 310 320 330 340 350 360 ATIGTGAQIA ASSNVKGDVP PGVRWGGSPA KPVREWFREV TTLKRLAAAS ARRGGNDGEG EGSGE

References

[1]

"Complete sequence of chromosome of Xanthobacter autotrophicus Py2." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000781 Genomic DNA. Translation: ABS69651.1.
RefSeq	YP_001419308.1. NC_009720.1.
3D structure databases
ProteinModelPortal	A7INQ7.
ModBase	Search...
Protein-protein interaction databases
STRING	A7INQ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5425102.
GenomeReviews	Gene locus Xaut_4430 in contig CP000781_GR.
KEGG	xau:Xaut_4430.
PATRIC	24051062. VBIXanAut29526_4786.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	VQIGRVI.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	XAUT78245:XAUT_4430-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 5 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A7INQ7_XANP2

Accession

Primary (citable) accession number: A7INQ7

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)