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A7INE4 (A7INE4_XANP2) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897
Ordered Locus Names:Xaut_4317 EMBL ABS69538.1
OrganismXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP] EMBL ABS69538.1
Taxonomic identifier78245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter ›

Protein attributes

Sequence length914 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1311O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
A7INE4 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 1D6470B48F5E2148

FASTA914100,538
        10         20         30         40         50         60 
MADSETPKPG GEPPSDIRPV SITEELSRSY LDYAMSVIVA RALPDVRDGL KPVHRRILFS 

        70         80         90        100        110        120 
MHENGYEWNK SYRKSARVVG DVIGKYHPHG DQSVYDALVR MAQTFAMRLP LVDGQGNFGS 

       130        140        150        160        170        180 
VDGDAPAAMR YTEVRLEKVT NALLDDLDKD TVDFQDNYDN SEHEPTVLPA KFPNLLVNGA 

       190        200        210        220        230        240 
GGIAVGMATN IPPHNLGEIV DTTVALLDDP TLEPEALLDL LPGPDFPTGA LILGRTGIRQ 

       250        260        270        280        290        300 
AYLTGRGSIL MRAKVAIENI RKEREALIVT EIPYQVNKAT MIEKMAELVR DKRIEGIAEI 

       310        320        330        340        350        360 
RDESDRDGMR VVIEIKRDAQ ADVVLNNLYR LTLLQTSFGV NMVALSGGKP GVLTLHDVLT 

       370        380        390        400        410        420 
AFIAFREEVI SRRTKFLLRK ARDRAHVLVG LAIAVANIDE VIRLIRTAPD PASAREALMA 

       430        440        450        460        470        480 
RDWPAKDMAP LIALIADPRH KLGPDDTYRL SFEQARAILD LRLQRLTALG RDEIAEELDK 

       490        500        510        520        530        540 
LAVEIADYLD ILASRPRMRA IVRAELIAIK EEFGTPRRTE IVEGFGDLED EDLIQREEMV 

       550        560        570        580        590        600 
VTVSHAGYIK RVPLSTYRAQ RRGGKGRSAM QTRDEDFVTR LFVASTHAPV LFFSSKGQVY 

       610        620        630        640        650        660 
KLKVWRLPLA APQARGKALI NILPLEQDER ITSVVLLPED SDENERLQIM FATTGGTVRR 

       670        680        690        700        710        720 
NALTDFQQVN RNGKIAMKLN EGEAIADVGL CTEDDDVLLT TAAGACIRFP VTDVRVFKGR 

       730        740        750        760        770        780 
DSVGVRGIRL EDGDTIISMA IIGHVDASAE ERLAYIKRRR ALAGEATEAG DVEAEEGASG 

       790        800        810        820        830        840 
NGHLGQDRYA EMGAKEQFIL TVSENGYGKR TSSYEYRVTG RGGKGIVAMA VNERNGRLVA 

       850        860        870        880        890        900 
SFPVEDQDQI MLVTDGGQLI RCPVDGIRIV GRASQGVIVF DTAEGERVVS VEHISDDAGA 

       910 
ENSDGEEPGE ATEA

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References

[1]"Complete sequence of chromosome of Xanthobacter autotrophicus Py2."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000781 Genomic DNA. Translation: ABS69538.1.
RefSeqYP_001419195.1. NC_009720.1.

3D structure databases

ProteinModelPortalA7INE4.
SMRA7INE4. Positions 39-522.
ModBaseSearch...

Protein-protein interaction databases

STRING78245.Xaut_4317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS69538; ABS69538; Xaut_4317.
GeneID5423685.
KEGGxau:Xaut_4317.
PATRIC24050824. VBIXanAut29526_4670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA7INE4_XANP2
AccessionPrimary (citable) accession number: A7INE4
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info