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A7INE1

- TRMFO_XANP2

UniProt

A7INE1 - TRMFO_XANP2

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciXAUT78245:GHS6-4368-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmFOUniRule annotation
    Ordered Locus Names:Xaut_4314
    OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
    Taxonomic identifieri78245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
    ProteomesiUP000002417: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000346421Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi78245.Xaut_4314.

    Structurei

    3D structure databases

    ProteinModelPortaliA7INE1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1206.
    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.
    OrthoDBiEOG6J74VT.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7INE1-1 [UniParc]FASTAAdd to Basket

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    MPQSADPVHV VGGGLAGSEA AWQIATRGVP VVLHEMRPQR TTDAHLTDGL    50
    AELVCSNSFR SDDPEGNAVG VLHAEMRQAG SLILTAADQN QVPAGGALAV 100
    DRDGFSRAVT KALEDHPLIE IRREELTTLP PAEWDKVILA TGPLTSPALA 150
    EAVLSLTGET ALAFFDAIAP IVHFDSIDMG KAWFQSRYDK PGPGGTGADY 200
    INCPLDEAQY HAFVDALIAG EKAPMRDFEA KTPYFDGCLP IEVMAERGRE 250
    TLRFGPMKPV GLTNPHNPTV KAYAIVQLRQ DNKLGTLYNM VGFQTKLRHG 300
    EQARVFRTIP GLENAEFARL GGLHRNTYLN SPRLLDGTLR LKADPRLRFA 350
    GQITGCEGYV ESAAVGLMAG RFAAAERRGE ALVPPPLTTA HGALLAHITG 400
    GHVEAEEAGA PRSFQPMNIN FGLFPPLEEA PRGEPGKRLR GAEKTLAKKK 450
    AMAARALAHM AAWLDTPARA A 471
    Length:471
    Mass (Da):50,555
    Last modified:September 11, 2007 - v1
    Checksum:iA24CF40C4C5BD638
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000781 Genomic DNA. Translation: ABS69535.1.
    RefSeqiYP_001419192.1. NC_009720.1.

    Genome annotation databases

    EnsemblBacteriaiABS69535; ABS69535; Xaut_4314.
    GeneIDi5422457.
    KEGGixau:Xaut_4314.
    PATRICi24050814. VBIXanAut29526_4665.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000781 Genomic DNA. Translation: ABS69535.1 .
    RefSeqi YP_001419192.1. NC_009720.1.

    3D structure databases

    ProteinModelPortali A7INE1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 78245.Xaut_4314.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS69535 ; ABS69535 ; Xaut_4314 .
    GeneIDi 5422457.
    KEGGi xau:Xaut_4314.
    PATRICi 24050814. VBIXanAut29526_4665.

    Phylogenomic databases

    eggNOGi COG1206.
    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.
    OrthoDBi EOG6J74VT.

    Enzyme and pathway databases

    BioCyci XAUT78245:GHS6-4368-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1158 / Py2.

    Entry informationi

    Entry nameiTRMFO_XANP2
    AccessioniPrimary (citable) accession number: A7INE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3