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A7INE1

- TRMFO_XANP2

UniProt

A7INE1 - TRMFO_XANP2

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Protein
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO
Gene
trmFO, Xaut_4314
Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176FAD By similarity

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciXAUT78245:GHS6-4368-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC:2.1.1.74)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase
Folate-dependent tRNA(M-5-U54)-methyltransferase
Gene namesi
Name:trmFO
Ordered Locus Names:Xaut_4314
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
ProteomesiUP000002417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation
PRO_0000346421Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi78245.Xaut_4314.

Structurei

3D structure databases

ProteinModelPortaliA7INE1.

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiEIYFEGC.
OrthoDBiEOG6J74VT.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7INE1-1 [UniParc]FASTAAdd to Basket

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MPQSADPVHV VGGGLAGSEA AWQIATRGVP VVLHEMRPQR TTDAHLTDGL    50
AELVCSNSFR SDDPEGNAVG VLHAEMRQAG SLILTAADQN QVPAGGALAV 100
DRDGFSRAVT KALEDHPLIE IRREELTTLP PAEWDKVILA TGPLTSPALA 150
EAVLSLTGET ALAFFDAIAP IVHFDSIDMG KAWFQSRYDK PGPGGTGADY 200
INCPLDEAQY HAFVDALIAG EKAPMRDFEA KTPYFDGCLP IEVMAERGRE 250
TLRFGPMKPV GLTNPHNPTV KAYAIVQLRQ DNKLGTLYNM VGFQTKLRHG 300
EQARVFRTIP GLENAEFARL GGLHRNTYLN SPRLLDGTLR LKADPRLRFA 350
GQITGCEGYV ESAAVGLMAG RFAAAERRGE ALVPPPLTTA HGALLAHITG 400
GHVEAEEAGA PRSFQPMNIN FGLFPPLEEA PRGEPGKRLR GAEKTLAKKK 450
AMAARALAHM AAWLDTPARA A 471
Length:471
Mass (Da):50,555
Last modified:September 11, 2007 - v1
Checksum:iA24CF40C4C5BD638
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS69535.1.
RefSeqiYP_001419192.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaiABS69535; ABS69535; Xaut_4314.
GeneIDi5422457.
KEGGixau:Xaut_4314.
PATRICi24050814. VBIXanAut29526_4665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS69535.1 .
RefSeqi YP_001419192.1. NC_009720.1.

3D structure databases

ProteinModelPortali A7INE1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 78245.Xaut_4314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS69535 ; ABS69535 ; Xaut_4314 .
GeneIDi 5422457.
KEGGi xau:Xaut_4314.
PATRICi 24050814. VBIXanAut29526_4665.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi EIYFEGC.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci XAUT78245:GHS6-4368-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1158 / Py2.

Entry informationi

Entry nameiTRMFO_XANP2
AccessioniPrimary (citable) accession number: A7INE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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