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A7INE1

- TRMFO_XANP2

UniProt

A7INE1 - TRMFO_XANP2

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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FAD.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176FADUniRule annotation

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciXAUT78245:GHS6-4368-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Xaut_4314
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
ProteomesiUP000002417: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000346421Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi78245.Xaut_4314.

Structurei

3D structure databases

ProteinModelPortaliA7INE1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1206.
HOGENOMiHOG000252054.
KOiK04094.
OMAiEIYFEGC.
OrthoDBiEOG6J74VT.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7INE1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MPQSADPVHV VGGGLAGSEA AWQIATRGVP VVLHEMRPQR TTDAHLTDGL
60 70 80 90 100
AELVCSNSFR SDDPEGNAVG VLHAEMRQAG SLILTAADQN QVPAGGALAV
110 120 130 140 150
DRDGFSRAVT KALEDHPLIE IRREELTTLP PAEWDKVILA TGPLTSPALA
160 170 180 190 200
EAVLSLTGET ALAFFDAIAP IVHFDSIDMG KAWFQSRYDK PGPGGTGADY
210 220 230 240 250
INCPLDEAQY HAFVDALIAG EKAPMRDFEA KTPYFDGCLP IEVMAERGRE
260 270 280 290 300
TLRFGPMKPV GLTNPHNPTV KAYAIVQLRQ DNKLGTLYNM VGFQTKLRHG
310 320 330 340 350
EQARVFRTIP GLENAEFARL GGLHRNTYLN SPRLLDGTLR LKADPRLRFA
360 370 380 390 400
GQITGCEGYV ESAAVGLMAG RFAAAERRGE ALVPPPLTTA HGALLAHITG
410 420 430 440 450
GHVEAEEAGA PRSFQPMNIN FGLFPPLEEA PRGEPGKRLR GAEKTLAKKK
460 470
AMAARALAHM AAWLDTPARA A
Length:471
Mass (Da):50,555
Last modified:September 11, 2007 - v1
Checksum:iA24CF40C4C5BD638
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS69535.1.
RefSeqiWP_012116283.1. NC_009720.1.
YP_001419192.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaiABS69535; ABS69535; Xaut_4314.
GeneIDi5422457.
KEGGixau:Xaut_4314.
PATRICi24050814. VBIXanAut29526_4665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS69535.1 .
RefSeqi WP_012116283.1. NC_009720.1.
YP_001419192.1. NC_009720.1.

3D structure databases

ProteinModelPortali A7INE1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 78245.Xaut_4314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS69535 ; ABS69535 ; Xaut_4314 .
GeneIDi 5422457.
KEGGi xau:Xaut_4314.
PATRICi 24050814. VBIXanAut29526_4665.

Phylogenomic databases

eggNOGi COG1206.
HOGENOMi HOG000252054.
KOi K04094.
OMAi EIYFEGC.
OrthoDBi EOG6J74VT.

Enzyme and pathway databases

BioCyci XAUT78245:GHS6-4368-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
PROSITEi PS01281. GIDA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1158 / Py2.

Entry informationi

Entry nameiTRMFO_XANP2
AccessioniPrimary (citable) accession number: A7INE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3