A7INB5 (A7INB5_XANP2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NADPH-dependent 7-cyano-7-deazaguanine reductase HAMAP MF_00818
EC=1.7.1.13 HAMAP MF_00818

Alternative name(s):
7-cyano-7-carbaguanine reductase HAMAP MF_00818
NADPH-dependent nitrile oxidoreductase HAMAP MF_00818
PreQ(0) reductase HAMAP MF_00818

Gene names

Name:	queF HAMAP MF_00818
Ordered Locus Names:	Xaut_4288

Organism

Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]

Taxonomic identifier

78245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity. HAMAP MF_00818 SAAS SAAS016856
Catalytic activity	7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH. HAMAP MF_00818 SAAS SAAS016856
Pathway	tRNA modification; tRNA-queuosine biosynthesis. HAMAP MF_00818 SAAS SAAS016856
Subcellular location	Cytoplasm By similarity HAMAP MF_00818 SAAS SAAS016856.
Sequence similarities	Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. HAMAP MF_00818

Ontologies

Keywords
Biological process	Queuosine biosynthesis HAMAP MF_00818 SAAS SAAS016856
Cellular component	Cytoplasm HAMAP MF_00818 SAAS SAAS016856
Ligand	NADP HAMAP MF_00818 SAAS SAAS016856
Molecular function	Hydrolase EMBL ABS69509.1 Oxidoreductase HAMAP MF_00818 SAAS SAAS016856
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	queuosine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Inferred from electronic annotation. Source: HAMAP preQ1 synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A7INB5 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 6116BF95E25E73D4	FASTA	150	16,667
	10 20 30 40 50 60 MTDRPLQLGV SAALPASPEE AVLDRVPNPH PDVDYVARFT CPEFTSLCPV TGQPDFAHIV 70 80 90 100 110 120 IDYVPDQFLV ESKSLKLYLG SFRNHGAFHE DCTVAVGKRL VDLLKPRFLR IAGYWYPRGG 130 140 150 IPIDVFWQTG KLAEGVWLPD TGVAPYRGRG

References

[1]

"Complete sequence of chromosome of Xanthobacter autotrophicus Py2." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000781 Genomic DNA. Translation: ABS69509.1.
RefSeq	YP_001419166.1. NC_009720.1.
3D structure databases
ProteinModelPortal	A7INB5.
ModBase	Search...
Protein-protein interaction databases
STRING	A7INB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5423672.
GenomeReviews	Gene locus Xaut_4288 in contig CP000781_GR.
KEGG	xau:Xaut_4288.
PATRIC	24050758. VBIXanAut29526_4637.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0780.
HOGENOM	HBG294103.
OMA	HEDCTVA.
ProtClustDB	PRK13258.
Enzyme and pathway databases
BioCyc	XAUT78245:XAUT_4288-MONOMER.
Family and domain databases
HAMAP	MF_00818. QueF_type1. [Tree]
InterPro	IPR016856. CN_OxRdtase_NADPH-dep_QueF. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. [Graphical view]
KO	K09457.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
PIRSF	PIRSF027377. Nitrile_oxidored_QueF. 1 hit.
TIGRFAMs	TIGR03139. QueF-II. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A7INB5_XANP2

Accession

Primary (citable) accession number: A7INB5

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)