UniProtKB - A7IMB0 (LLDD_XANP2)
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Protein
L-lactate dehydrogenase
Gene
lldD
Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Functioni
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation
Catalytic activityi
(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation
Cofactori
FMNUniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 24 | SubstrateUniRule annotation | 1 | |
Binding sitei | 106 | FMNUniRule annotation | 1 | |
Binding sitei | 127 | FMNUniRule annotation | 1 | |
Binding sitei | 129 | SubstrateUniRule annotation | 1 | |
Binding sitei | 155 | FMNUniRule annotation | 1 | |
Binding sitei | 164 | SubstrateUniRule annotation | 1 | |
Binding sitei | 251 | FMNUniRule annotation | 1 | |
Active sitei | 275 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 278 | SubstrateUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 306 – 330 | FMNUniRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- FMN binding Source: InterPro
- lactate dehydrogenase activity Source: InterPro
GO - Biological processi
- lactate metabolic process Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Flavoprotein, FMN |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lldDUniRule annotation Ordered Locus Names:Xaut_3929 |
Organismi | Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) |
Taxonomic identifieri | 78245 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000383452 | 1 – 388 | L-lactate dehydrogenaseAdd BLAST | 388 |
Structurei
3D structure databases
ProteinModelPortali | A7IMB0. |
SMRi | A7IMB0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 380 | FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST | 380 |
Sequence similaritiesi
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105DMF. Bacteria. COG1304. LUCA. |
HOGENOMi | HOG000217464. |
KOi | K00101. |
OMAi | MQLYIYK. |
OrthoDBi | POG091H00L7. |
Family and domain databases
CDDi | cd02809. alpha_hydroxyacid_oxid_FMN. 1 hit. |
Gene3Di | 3.20.20.70. 1 hit. |
HAMAPi | MF_01559. L_lact_dehydr. 1 hit. |
InterProi | View protein in InterPro IPR013785. Aldolase_TIM. IPR012133. Alpha-hydoxy_acid_DH_FMN. IPR000262. FMN-dep_DH. IPR037396. FMN_HAD. IPR008259. FMN_hydac_DH_AS. IPR020920. LldD. |
Pfami | View protein in Pfam PF01070. FMN_dh. 1 hit. |
PIRSFi | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
PROSITEi | View protein in PROSITE PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
A7IMB0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIISSSSDYR EAARRRLPPF LFHYIDGGAY AEATLRRNVE DLSDLALRQR
60 70 80 90 100
VLKSVGEVDL STTLLKQQLS MPVGLAPVGL TGMYARRGEV QAAQAATQKG
110 120 130 140 150
IPFTLSTVSV CSIEEVQSQV GKPIWFQLYV LKDRGFMKNA LERAWAAGIR
160 170 180 190 200
TLVFTVDMPV PGARYRDAHS GMSGPNAAFR RMVQAVLHPF WAYDVGLMGT
210 220 230 240 250
PHDLGNVSAY RKEKTSLEDY VGWLGNNFDP SIGWKDLEWI REFWKGPMVI
260 270 280 290 300
KGILDPEDAR DAVRFGADGI IVSNHGGRQL DGVLSSARAM PAIADAVKGE
310 320 330 340 350
MTLLADSGIR SGLDVVRMLA QGADGVLLGR AFVYALAAAG RAGVENLLDI
360 370 380
IAKEMRVAMT LTGARAISDI SRDSLVREIE RPLARAAQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000781 Genomic DNA. Translation: ABS69153.1. |
RefSeqi | WP_012115901.1. NC_009720.1. |
Genome annotation databases
EnsemblBacteriai | ABS69153; ABS69153; Xaut_3929. |
KEGGi | xau:Xaut_3929. |
Similar proteinsi
Entry informationi
Entry namei | LLDD_XANP2 | |
Accessioni | A7IMB0Primary (citable) accession number: A7IMB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | September 11, 2007 | |
Last modified: | December 20, 2017 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |