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A7IMB0 (LLDD_XANP2) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase [cytochrome]
EC=1.1.2.3
Gene names
Name:lldD
Ordered Locus Names:Xaut_3929
OrganismXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]
Taxonomic identifier78245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter ›

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP-Rule MF_01559

Cofactor

FMN By similarity. HAMAP-Rule MF_01559

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
   LigandFlavoprotein
FMN
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlactate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388L-lactate dehydrogenase [cytochrome] HAMAP-Rule MF_01559
PRO_0000383452

Regions

Domain1 – 380380FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
A7IMB0 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: FECA89D3F350ED3E

FASTA38842,335
        10         20         30         40         50         60 
MIISSSSDYR EAARRRLPPF LFHYIDGGAY AEATLRRNVE DLSDLALRQR VLKSVGEVDL 

        70         80         90        100        110        120 
STTLLKQQLS MPVGLAPVGL TGMYARRGEV QAAQAATQKG IPFTLSTVSV CSIEEVQSQV 

       130        140        150        160        170        180 
GKPIWFQLYV LKDRGFMKNA LERAWAAGIR TLVFTVDMPV PGARYRDAHS GMSGPNAAFR 

       190        200        210        220        230        240 
RMVQAVLHPF WAYDVGLMGT PHDLGNVSAY RKEKTSLEDY VGWLGNNFDP SIGWKDLEWI 

       250        260        270        280        290        300 
REFWKGPMVI KGILDPEDAR DAVRFGADGI IVSNHGGRQL DGVLSSARAM PAIADAVKGE 

       310        320        330        340        350        360 
MTLLADSGIR SGLDVVRMLA QGADGVLLGR AFVYALAAAG RAGVENLLDI IAKEMRVAMT 

       370        380 
LTGARAISDI SRDSLVREIE RPLARAAQ

« Hide

References

[1]"Complete sequence of chromosome of Xanthobacter autotrophicus Py2."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000781 Genomic DNA. Translation: ABS69153.1.
RefSeqYP_001418810.1. NC_009720.1.

3D structure databases

ProteinModelPortalA7IMB0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING78245.Xaut_3929.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS69153; ABS69153; Xaut_3929.
GeneID5422902.
KEGGxau:Xaut_3929.
PATRIC24050014. VBIXanAut29526_4273.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1304.
HOGENOMHOG000217464.
KOK00101.
OMAPWFQLYM.
OrthoDBEOG6HMXBG.

Enzyme and pathway databases

BioCycXAUT78245:GHS6-3975-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01559. L_lact_dehydr.
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view]
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLLDD_XANP2
AccessionPrimary (citable) accession number: A7IMB0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 11, 2007
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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