lldD

Functionⁱ

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityⁱ

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactorⁱ

FMNUniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	24	SubstrateUniRule annotation	1
Binding siteⁱ	106	FMNUniRule annotation	1
Binding siteⁱ	127	FMNUniRule annotation	1
Binding siteⁱ	129	SubstrateUniRule annotation	1
Binding siteⁱ	155	FMNUniRule annotation	1
Binding siteⁱ	164	SubstrateUniRule annotation	1
Binding siteⁱ	251	FMNUniRule annotation	1
Active siteⁱ	275	Proton acceptorUniRule annotation	1
Binding siteⁱ	278	SubstrateUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	306 – 330	FMNUniRule annotationAdd BLAST		25

GO - Molecular functionⁱ

FMN binding Source: InterPro
lactate dehydrogenase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lactate metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Flavoprotein, FMN

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesⁱ	Name:lldDUniRule annotation Ordered Locus Names:Xaut_3929
Organismⁱ	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifierⁱ	78245 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter › Xanthobacter autotrophicus
Proteomesⁱ	UP000002417 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell inner membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01559
; Peripheral membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01559

GO - Cellular componentⁱ

plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000383452	1 – 388	L-lactate dehydrogenaseAdd BLAST		388

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	78245.Xaut_3929.

STRINGⁱ

78245.Xaut_3929.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A7IMB0.
SMRⁱ	A7IMB0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 380	FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST		380

Sequence similaritiesⁱ

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105DMF. Bacteria. COG1304. LUCA.
HOGENOMⁱ	HOG000217464.
KEGG Orthology (KO) More...KOⁱ	K00101.
OMAⁱ	MQLYIYK.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00L7.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02809. alpha_hydroxyacid_oxid_FMN. 1 hit.
Gene3Dⁱ	3.20.20.70. 1 hit.
HAMAPⁱ	MF_01559. L_lact_dehydr. 1 hit.
InterProⁱ	View protein in InterPro IPR013785. Aldolase_TIM. IPR012133. Alpha-hydoxy_acid_DH_FMN. IPR000262. FMN-dep_DH. IPR037396. FMN_HAD. IPR008259. FMN_hydac_DH_AS. IPR020920. LldD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01070. FMN_dh. 1 hit.
PIRSFⁱ	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A7IMB0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIISSSSDYR EAARRRLPPF LFHYIDGGAY AEATLRRNVE DLSDLALRQR 
        60         70         80         90        100
VLKSVGEVDL STTLLKQQLS MPVGLAPVGL TGMYARRGEV QAAQAATQKG 
       110        120        130        140        150
IPFTLSTVSV CSIEEVQSQV GKPIWFQLYV LKDRGFMKNA LERAWAAGIR 
       160        170        180        190        200
TLVFTVDMPV PGARYRDAHS GMSGPNAAFR RMVQAVLHPF WAYDVGLMGT 
       210        220        230        240        250
PHDLGNVSAY RKEKTSLEDY VGWLGNNFDP SIGWKDLEWI REFWKGPMVI 
       260        270        280        290        300
KGILDPEDAR DAVRFGADGI IVSNHGGRQL DGVLSSARAM PAIADAVKGE 
       310        320        330        340        350
MTLLADSGIR SGLDVVRMLA QGADGVLLGR AFVYALAAAG RAGVENLLDI 
       360        370        380 
IAKEMRVAMT LTGARAISDI SRDSLVREIE RPLARAAQ

Length:388

Mass (Da):42,335

Last modified:September 11, 2007 - v1

Checksum:ⁱFECA89D3F350ED3E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000781 Genomic DNA. Translation: ABS69153.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012115901.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABS69153; ABS69153; Xaut_3929.
KEGGⁱ	xau:Xaut_3929.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A7IMB0	A4XYG7 F4DVY1 A0A0F3GFL1 A0A087F771 UPI0007DC0860 U2AXV1 UPI0005A9BD38 U1SV83 A0A1L7G3Q3 A0A1H0XET9 +1265	Pseudomonas mendocina (strain ymp) Pseudomonas mendocina (strain NK-01) Pseudomonas pseudoalcaligenes Pseudomonas sp. 1-7 Pseudomonas alcaliphila Pseudomonas sp. EGD-AK9 Pseudomonas mendocina Pseudomonas mendocina EGD-AQ5 Pseudomonas alcaliphila JAB1 Pseudomonas guguanensis And more	379	UniRef50_A4XYG7	Cluster: L-lactate dehydrogenase	1,276

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000781 Genomic DNA. Translation: ABS69153.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012115901.1. NC_009720.1.

3D structure databases

ProteinModelPortalⁱ	A7IMB0.
SMRⁱ	A7IMB0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	78245.Xaut_3929.

STRINGⁱ

78245.Xaut_3929.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABS69153; ABS69153; Xaut_3929.
KEGGⁱ	xau:Xaut_3929.

Phylogenomic databases

eggNOGⁱ	ENOG4105DMF. Bacteria. COG1304. LUCA.
HOGENOMⁱ	HOG000217464.
KEGG Orthology (KO) More...KOⁱ	K00101.
OMAⁱ	MQLYIYK.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H00L7.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02809. alpha_hydroxyacid_oxid_FMN. 1 hit.
Gene3Dⁱ	3.20.20.70. 1 hit.
HAMAPⁱ	MF_01559. L_lact_dehydr. 1 hit.
InterProⁱ	View protein in InterPro IPR013785. Aldolase_TIM. IPR012133. Alpha-hydoxy_acid_DH_FMN. IPR000262. FMN-dep_DH. IPR037396. FMN_HAD. IPR008259. FMN_hydac_DH_AS. IPR020920. LldD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01070. FMN_dh. 1 hit.
PIRSFⁱ	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LLDD_XANP2
Accessionⁱ	A7IMB0Primary (citable) accession number: A7IMB0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
	Last sequence update:	September 11, 2007
	Last modified:	December 20, 2017
	This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A7IMB0 (LLDD_XANP2)

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L-lactate dehydrogenase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ