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Protein

Fructose-1,6-bisphosphatase class 1 2

Gene

fbp2

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92Magnesium 1UniRule annotation1
Metal bindingi111Magnesium 1UniRule annotation1
Metal bindingi111Magnesium 2UniRule annotation1
Metal bindingi113Magnesium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi114Magnesium 2UniRule annotation1
Binding sitei206SubstrateUniRule annotation1
Metal bindingi278Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase class 1 2UniRule annotation (EC:3.1.3.11UniRule annotation)
Short name:
FBPase class 1 2UniRule annotation
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2UniRule annotation
Gene namesi
Name:fbp2UniRule annotation
Ordered Locus Names:Xaut_3528
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
Proteomesi
  • UP000002417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003647491 – 329Fructose-1,6-bisphosphatase class 1 2Add BLAST329

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi78245.Xaut_3528.

Structurei

3D structure databases

ProteinModelPortaliA7IL64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni114 – 117Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the FBPase class 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZI. Bacteria.
COG0158. LUCA.
HOGENOMiHOG000191264.
KOiK03841.
OMAiWPKPIRA.
OrthoDBiPOG091H05DB.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IL64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELVTLKTY LGTWAGADTG RTAVAQAVTA IAEAGVGIAD LVARGPLEEG
60 70 80 90 100
LASIRGVDPN AGGDAQKELD VVAEERIKAA LLPTPTAFLA SEESEELIPL
110 120 130 140 150
NPDGRLVIAV DPLDGSSNID TNVSVGTIYS ILPYDAAVHT DPVSAVMRPG
160 170 180 190 200
VNQVASGFLA YGPATILVAT FGEGTQVFVH DRQTGEFVLA RTNVEIPAET
210 220 230 240 250
KEYGVNQSNV RHWAEPMSAY IADCLAGKDG PRGKDFNMRW VGSMVADAFR
260 270 280 290 300
IFTRGGVYVY PGDKRKGYEN GRLRLIYEAN PVAFLTEQAK GAATDGKTRI
310 320
LDIQPHHIHQ RIPLVFGSKA EVEKIASYY
Length:329
Mass (Da):35,230
Last modified:September 11, 2007 - v1
Checksum:i81389412FDEDA1FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000781 Genomic DNA. Translation: ABS68757.1.
RefSeqiWP_012115503.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaiABS68757; ABS68757; Xaut_3528.
KEGGixau:Xaut_3528.
PATRICi24049208. VBIXanAut29526_3876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000781 Genomic DNA. Translation: ABS68757.1.
RefSeqiWP_012115503.1. NC_009720.1.

3D structure databases

ProteinModelPortaliA7IL64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi78245.Xaut_3528.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS68757; ABS68757; Xaut_3528.
KEGGixau:Xaut_3528.
PATRICi24049208. VBIXanAut29526_3876.

Phylogenomic databases

eggNOGiENOG4105CZI. Bacteria.
COG0158. LUCA.
HOGENOMiHOG000191264.
KOiK03841.
OMAiWPKPIRA.
OrthoDBiPOG091H05DB.

Enzyme and pathway databases

UniPathwayiUPA00138.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF16A2_XANP2
AccessioniPrimary (citable) accession number: A7IL64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.