Reviewed, UniProtKB/Swiss-Prot A7IL64 (F16A2_XANP2)

Names and origin

Protein names

Recommended name:
    Fructose-1,6-bisphosphatase class 1 2
      Short name=FBPase class 1 2
    EC=3.1.3.11
Alternative name(s):
    D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2

Gene names

Name:	fbp2
Ordered Locus Names:	Xaut_3528

Organism

Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]

Taxonomic identifier

78245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Fructose-1,6-bisphosphatase class 1 2 HAMAP MF_01855		PRO_0000364749
Regions
	Region	114 – 117	4	Substrate binding By similarity
Sites
	Metal binding	92	1	Magnesium 1 By similarity
	Metal binding	111	1	Magnesium 1 By similarity
	Metal binding	111	1	Magnesium 2 By similarity
	Metal binding	113	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	114	1	Magnesium 2 By similarity
	Metal binding	278	1	Magnesium 2 By similarity
	Binding site	206	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7IL64-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 81389412FDEDA1FB	FASTA	329	35,230
	10 20 30 40 50 60 MSELVTLKTY LGTWAGADTG RTAVAQAVTA IAEAGVGIAD LVARGPLEEG LASIRGVDPN 70 80 90 100 110 120 AGGDAQKELD VVAEERIKAA LLPTPTAFLA SEESEELIPL NPDGRLVIAV DPLDGSSNID 130 140 150 160 170 180 TNVSVGTIYS ILPYDAAVHT DPVSAVMRPG VNQVASGFLA YGPATILVAT FGEGTQVFVH 190 200 210 220 230 240 DRQTGEFVLA RTNVEIPAET KEYGVNQSNV RHWAEPMSAY IADCLAGKDG PRGKDFNMRW 250 260 270 280 290 300 VGSMVADAFR IFTRGGVYVY PGDKRKGYEN GRLRLIYEAN PVAFLTEQAK GAATDGKTRI 310 320 LDIQPHHIHQ RIPLVFGSKA EVEKIASYY

References

[1]

"Complete sequence of chromosome of Xanthobacter autotrophicus Py2." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000781 Genomic DNA. Translation: ABS68757.1.
RefSeq	YP_001418414.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7IL64.
Genome annotation databases
GeneID	5421277.
GenomeReviews	Gene locus Xaut_3528 in contig CP000781_GR.
KEGG	xau:Xaut_3528.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QRHWEAP.
Family and domain databases
HAMAP	MF_01855. [Tree]
InterPro	IPR000146. Fructose_bisphosphatase. IPR020548. Fructose_bisphosphatase_AS. [Graphical view]
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PRINTS	PR00115. F16BPHPHTASE.
ProDom	PD001491. In_FB_phphtase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00124. FBPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16A2_XANP2

Accession

Primary (citable) accession number: A7IL64

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)