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A7IJ81

- PDXA_XANP2

UniProt

A7IJ81 - PDXA_XANP2

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, Xaut_2834
Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381Substrate By similarity
Binding sitei139 – 1391Substrate By similarity
Metal bindingi173 – 1731Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi218 – 2181Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi273 – 2731Divalent metal cation; shared with dimeric partner By similarity
Binding sitei281 – 2811Substrate By similarity
Binding sitei290 – 2901Substrate By similarity
Binding sitei299 – 2991Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. cobalt ion binding Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

BioCyciXAUT78245:GHS6-2862-MONOMER.
UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:Xaut_2834
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
ProteomesiUP000002417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3503504-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_1000128267Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi78245.Xaut_2834.

Structurei

3D structure databases

ProteinModelPortaliA7IJ81.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221592.
KOiK00097.
OMAiDTLFQDK.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

A7IJ81-1 [UniParc]FASTAAdd to Basket

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MVAPAPLVLS LGDPAGIGPD ITLTAWAQRR ELGLPAFLVA GDPEALKARV    50
RQLGLTVPLA ETGPEDAAGH FAEALPVMPA GPASTALPGA PDASSAPCVV 100
ASLEAALGLV QAGRAAALVT NPLAKSVMYA GGFPFPGHTE FLAARAARPG 150
RPAPHPVMMI WSEQLAVVPA TIHLPYADVP GHLTIDLLVE TGRIVAGDMA 200
RRFGLAHPRL VFCGLNPHAG EEGTLGTEDE AIVRPAVEAL KREGIDARGP 250
LPADTLFHPQ ARAGYDVAVG MYHDQVLIPA KTLAFHDGVN VTLGLPFIRT 300
SPDHGTAFDI AGTGRANPSS LVAALRLARR LADAEARLAA REGHRAASVA 350
Length:350
Mass (Da):36,158
Last modified:September 11, 2007 - v1
Checksum:i2C9C5E058EEDC905
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS68074.1.
RefSeqiWP_012114825.1. NC_009720.1.
YP_001417731.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaiABS68074; ABS68074; Xaut_2834.
GeneIDi5423084.
KEGGixau:Xaut_2834.
PATRICi24047767. VBIXanAut29526_3168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS68074.1 .
RefSeqi WP_012114825.1. NC_009720.1.
YP_001417731.1. NC_009720.1.

3D structure databases

ProteinModelPortali A7IJ81.
ModBasei Search...

Protein-protein interaction databases

STRINGi 78245.Xaut_2834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS68074 ; ABS68074 ; Xaut_2834 .
GeneIDi 5423084.
KEGGi xau:Xaut_2834.
PATRICi 24047767. VBIXanAut29526_3168.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221592.
KOi K00097.
OMAi DTLFQDK.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .
BioCyci XAUT78245:GHS6-2862-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1158 / Py2.

Entry informationi

Entry nameiPDXA_XANP2
AccessioniPrimary (citable) accession number: A7IJ81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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