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A7IJ56 (GLPK_XANP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:Xaut_2809
OrganismXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]
Taxonomic identifier78245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Glycerol kinase HAMAP MF_00186
PRO_1000098774

Regions

Nucleotide binding411 – 4155ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site161ATP By similarity
Binding site821Substrate By similarity
Binding site1341Substrate By similarity
Binding site2431Substrate By similarity
Binding site2651ATP By similarity
Binding site3081ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A7IJ56 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 6658D7DE91470296

FASTA49753,505
        10         20         30         40         50         60 
MAAYILAIDQ GTTSSRALLV RRDGTIAALA QEELPQHFPA SGEVEQEAED IWNTVLSCCR 

        70         80         90        100        110        120 
VVLRQAGVGP SDIAAIGITN QRETTLVWER ATGRAIHRAI VWQDRRTADT CARLEAEGHG 

       130        140        150        160        170        180 
ALIRARTGLL IDPYFSATKI AHILEKVPGA RARAEKGELA FGTVDSFLLF RLTGGRVHAT 

       190        200        210        220        230        240 
DATNASRTML FDIHKGAWDD DLLALFGVPR ALLPEVRDCA AEFGATDPEM FGAPIPIRGM 

       250        260        270        280        290        300 
AGDQQAAMVG QACFQPGMVK STYGTGCFAL LNTGETPVAS RHRLITTIAY QIEGRRTYAL 

       310        320        330        340        350        360 
EGSIFVAGAA VQWLRDGLKM ISHAAESDRL AAEADEGQDV ILVPAFVGLG APYWRPQVRG 

       370        380        390        400        410        420 
ALFGLTRATG PAELARAALE AVCFQTCDLI DAMHADWPGQ SGATVLRVDG GMSASDFTMQ 

       430        440        450        460        470        480 
RLADLLGAPV DRPAETETTV LGAAYLAGLQ CGFFPPPDIF AQGWRLERRF VPAMADEVRA 

       490 
MRLAAWRSAV ECLIGRD

« Hide

References

[1]"Complete sequence of chromosome of Xanthobacter autotrophicus Py2."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000781 Genomic DNA. Translation: ABS68049.1.
RefSeqYP_001417706.1. NC_009720.1.

3D structure databases

ProteinModelPortalA7IJ56.
SMRA7IJ56. Positions 4-495.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7IJ56.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5422029.
GenomeReviewsGene locus Xaut_2809 in contig CP000781_GR.
KEGGxau:Xaut_2809.
PATRIC24047711. VBIXanAut29526_3141.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHBG511469.
OMACYQTRDL.

Enzyme and pathway databases

BioCycXAUT78245:XAUT_2809-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. False negative.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_XANP2
AccessionPrimary (citable) accession number: A7IJ56
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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