Reviewed, UniProtKB/Swiss-Prot A7IIX3 (TPMT_XANP2)

Names and origin

Protein names

Recommended name:
    Thiopurine S-methyltransferase
    EC=2.1.1.67
Alternative name(s):
    Thiopurine methyltransferase

Gene names

Name:	tpm
Ordered Locus Names:	Xaut_2726

Organism

Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]

Taxonomic identifier

78245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. TPMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiopurine S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Thiopurine S-methyltransferase HAMAP MF_00812		PRO_1000134083
Sites
	Binding site	10	1	S-adenosyl-L-methionine By similarity
	Binding site	46	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	67	1	S-adenosyl-L-methionine By similarity
	Binding site	124	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7IIX3-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 6A8A9F92D73CC261	FASTA	213	23,278
	10 20 30 40 50 60 MEPDFWHARW QTKQIQGFHE GKANAFLVKH FPRLPVAPGA RVFVPLCGKT RDIAWLLGEG 70 80 90 100 110 120 FRVAGAELSR IAVEELFAEL GVVPEVTTQG AHTRFSAPGL DIFQGDIFAL TPDTLGPVDA 130 140 150 160 170 180 VWDRAALVAL PKDMRARYAP HLVALTDTAP QLLVCFEYDQ PLLAGPPFSV PPEETRTLYG 190 200 210 ADYVVAAIDT APVPGGLKGQ CEAVEHVWLL ERA

References

[1]

"Complete sequence of chromosome of Xanthobacter autotrophicus Py2." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000781 Genomic DNA. Translation: ABS67966.1.
RefSeq	YP_001417623.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7IIX3.
Genome annotation databases
GeneID	5424104.
GenomeReviews	Gene locus Xaut_2726 in contig CP000781_GR.
KEGG	xau:Xaut_2726.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PPFAVSP.
Family and domain databases
HAMAP	MF_00812. [Tree]
InterPro	IPR008854. Thiopurine_S-MeTrfase. IPR016822. Thiopurine_S-MeTrfase_sub. [Graphical view]
Pfam	PF05724. TPMT. 1 hit. [Graphical view]
PIRSF	PIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPMT_XANP2

Accession

Primary (citable) accession number: A7IIX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)