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Protein

Thiopurine S-methyltransferase

Gene

tpm

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10S-adenosyl-L-methionineUniRule annotation1
Binding sitei46S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei67S-adenosyl-L-methionineUniRule annotation1
Binding sitei124S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Thiopurine S-methyltransferaseUniRule annotation (EC:2.1.1.67UniRule annotation)
Alternative name(s):
Thiopurine methyltransferaseUniRule annotation
Gene namesi
Name:tpmUniRule annotation
Ordered Locus Names:Xaut_2726
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
Proteomesi
  • UP000002417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001340831 – 213Thiopurine S-methyltransferaseAdd BLAST213

Interactioni

Protein-protein interaction databases

STRINGi78245.Xaut_2726.

Structurei

3D structure databases

ProteinModelPortaliA7IIX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FQ6. Bacteria.
ENOG4111GNF. LUCA.
HOGENOMiHOG000276919.
KOiK00569.
OMAiKWVNGKT.
OrthoDBiPOG091H046Q.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00812. Thiopur_methtran. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR025835. Thiopurine_S-MeTrfase.
IPR008854. TPMT.
[Graphical view]
PfamiPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFiPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR03840. TMPT_Se_Te. 1 hit.
PROSITEiPS51585. SAM_MT_TPMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IIX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPDFWHARW QTKQIQGFHE GKANAFLVKH FPRLPVAPGA RVFVPLCGKT
60 70 80 90 100
RDIAWLLGEG FRVAGAELSR IAVEELFAEL GVVPEVTTQG AHTRFSAPGL
110 120 130 140 150
DIFQGDIFAL TPDTLGPVDA VWDRAALVAL PKDMRARYAP HLVALTDTAP
160 170 180 190 200
QLLVCFEYDQ PLLAGPPFSV PPEETRTLYG ADYVVAAIDT APVPGGLKGQ
210
CEAVEHVWLL ERA
Length:213
Mass (Da):23,278
Last modified:September 11, 2007 - v1
Checksum:i6A8A9F92D73CC261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000781 Genomic DNA. Translation: ABS67966.1.
RefSeqiWP_012114717.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaiABS67966; ABS67966; Xaut_2726.
KEGGixau:Xaut_2726.
PATRICi24047541. VBIXanAut29526_3056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000781 Genomic DNA. Translation: ABS67966.1.
RefSeqiWP_012114717.1. NC_009720.1.

3D structure databases

ProteinModelPortaliA7IIX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi78245.Xaut_2726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS67966; ABS67966; Xaut_2726.
KEGGixau:Xaut_2726.
PATRICi24047541. VBIXanAut29526_3056.

Phylogenomic databases

eggNOGiENOG4105FQ6. Bacteria.
ENOG4111GNF. LUCA.
HOGENOMiHOG000276919.
KOiK00569.
OMAiKWVNGKT.
OrthoDBiPOG091H046Q.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00812. Thiopur_methtran. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR025835. Thiopurine_S-MeTrfase.
IPR008854. TPMT.
[Graphical view]
PfamiPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFiPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR03840. TMPT_Se_Te. 1 hit.
PROSITEiPS51585. SAM_MT_TPMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPMT_XANP2
AccessioniPrimary (citable) accession number: A7IIX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.