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A7IHV5 (A7IHV5_XANP2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH HAMAP MF_00191
Ordered Locus Names:Xaut_2355
OrganismXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]
Taxonomic identifier78245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191 SAAS SAAS003451

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191 SAAS SAAS003451

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191 SAAS SAAS003451

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191 SAAS SAAS003451

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
A7IHV5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 415BA121DAAB3263

FASTA33536,202
        10         20         30         40         50         60 
MPSIEPAMDP AAAPDAAAKP PLKILLAAPR GFCAGVVRAI DAVEQALKLY GAPVYVRHEI 

        70         80         90        100        110        120 
VHNKYVVEDL KRKGAIFVEE LDEVPDTSAP VIFSAHGVPK SVPDEATSRK LFAIDATCPL 

       130        140        150        160        170        180 
VTKVHREAQV HFRKGRHILL IGHEGHPEVV GTIGQLPDGA FTLIETAEDA RKVMPRDPDN 

       190        200        210        220        230        240 
LAYVTQTTLS LDDTAEMIAI LRERFPALSE PHKEDICYAT TNRQEAVKAI APRVDALVVV 

       250        260        270        280        290        300 
GAPNSSNSQR LREAAERAGC ARAVLVQRAA DIDWTVFSSI ASLGVTAGAS APEVLVEEII 

       310        320        330 
DAFVERFTVT VETVTSTEED VFFPLPRALR PDAAE

« Hide

References

[1]"Complete sequence of chromosome of Xanthobacter autotrophicus Py2."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000781 Genomic DNA. Translation: ABS67598.1.
RefSeqYP_001417255.1. NC_009720.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA7IHV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5422819.
GenomeReviewsGene locus Xaut_2355 in contig CP000781_GR.
KEGGxau:Xaut_2355.
PATRIC24046785. VBIXanAut29526_2680.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0761.
HOGENOMHBG335228.
OMAEENIAFP.
ProtClustDBPRK01045.

Enzyme and pathway databases

BioCycXAUT78245:XAUT_2355-MONOMER.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA7IHV5_XANP2
AccessionPrimary (citable) accession number: A7IHV5
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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