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A7IHE9

- GCSPA_XANP2

UniProt

A7IHE9 - GCSPA_XANP2

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, Xaut_2198
Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciXAUT78245:GHS6-2221-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Xaut_2198
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
ProteomesiUP000002417: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000132490Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi78245.Xaut_2198.

Structurei

3D structure databases

ProteinModelPortaliA7IHE9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A7IHE9-1 [UniParc]FASTAAdd to Basket

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MRYLPLTPED RAEMLARIGV ASVDELFVDI PADKRETALP RLALHKSELE    50
VERTLARLAG QNVPAGSVPF FVGAGAYRHH VPATVDHLIQ RSEFLTSYTP 100
YQPEIAQGTL QYLFEFQTQV AELTAMEVAN ASMYDGSTAA AEAVLMAHRV 150
TRRRKAVLAG NLHPHYRSTI ETVSRYAADE VVALPPAPFG EEDLITPIDD 200
TVSCVVVQSP DVFGNLVDLK PIAEAAHKAG ALLVAVFTEA VALGLIEPPG 250
AQGADIVVGE GQSIGNALNF GGPYVGLFAT RQKFVRQMPG RLAGETVDAE 300
GRRGFVLTLS TREQHIRREK ATSNICTNSG LCALAFTIHM SLLGKTGLTR 350
LARANHAAAC DLADRLAAVK GASVVNDTFF NEFTLRVPGP AADVVEKLAA 400
KGILAGVPYS RLAPKSGLDD LILVAATETT TEDDRAAYAA ALKEVL 446
Length:446
Mass (Da):47,690
Last modified:September 11, 2007 - v1
Checksum:iD7511D08076FADF7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS67442.1.
RefSeqiWP_012114226.1. NC_009720.1.
YP_001417099.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaiABS67442; ABS67442; Xaut_2198.
GeneIDi5424377.
KEGGixau:Xaut_2198.
PATRICi24046483. VBIXanAut29526_2531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS67442.1 .
RefSeqi WP_012114226.1. NC_009720.1.
YP_001417099.1. NC_009720.1.

3D structure databases

ProteinModelPortali A7IHE9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 78245.Xaut_2198.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS67442 ; ABS67442 ; Xaut_2198 .
GeneIDi 5424377.
KEGGi xau:Xaut_2198.
PATRICi 24046483. VBIXanAut29526_2531.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci XAUT78245:GHS6-2221-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1158 / Py2.

Entry informationi

Entry nameiGCSPA_XANP2
AccessioniPrimary (citable) accession number: A7IHE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi