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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Xaut_2198
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
Proteomesi
  • UP000002417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324901 – 446Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST446

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi78245.Xaut_2198

Structurei

3D structure databases

ProteinModelPortaliA7IHE9
SMRiA7IHE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A7IHE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPLTPED RAEMLARIGV ASVDELFVDI PADKRETALP RLALHKSELE
60 70 80 90 100
VERTLARLAG QNVPAGSVPF FVGAGAYRHH VPATVDHLIQ RSEFLTSYTP
110 120 130 140 150
YQPEIAQGTL QYLFEFQTQV AELTAMEVAN ASMYDGSTAA AEAVLMAHRV
160 170 180 190 200
TRRRKAVLAG NLHPHYRSTI ETVSRYAADE VVALPPAPFG EEDLITPIDD
210 220 230 240 250
TVSCVVVQSP DVFGNLVDLK PIAEAAHKAG ALLVAVFTEA VALGLIEPPG
260 270 280 290 300
AQGADIVVGE GQSIGNALNF GGPYVGLFAT RQKFVRQMPG RLAGETVDAE
310 320 330 340 350
GRRGFVLTLS TREQHIRREK ATSNICTNSG LCALAFTIHM SLLGKTGLTR
360 370 380 390 400
LARANHAAAC DLADRLAAVK GASVVNDTFF NEFTLRVPGP AADVVEKLAA
410 420 430 440
KGILAGVPYS RLAPKSGLDD LILVAATETT TEDDRAAYAA ALKEVL
Length:446
Mass (Da):47,690
Last modified:September 11, 2007 - v1
Checksum:iD7511D08076FADF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000781 Genomic DNA Translation: ABS67442.1
RefSeqiWP_012114226.1, NC_009720.1

Genome annotation databases

EnsemblBacteriaiABS67442; ABS67442; Xaut_2198
KEGGixau:Xaut_2198

Similar proteinsi

Entry informationi

Entry nameiGCSPA_XANP2
AccessioniPrimary (citable) accession number: A7IHE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 11, 2007
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health