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A7IH09 (A7IH09_XANP2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412
Gene names
Name:proA HAMAP MF_00412
Ordered Locus Names:Xaut_2058
OrganismXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]
Taxonomic identifier78245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412 SAAS SAAS020593

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 SAAS SAAS020593

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 SAAS SAAS020593

Subcellular location

Cytoplasm By similarity HAMAP MF_00412 SAAS SAAS020593.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Sequences

Sequence LengthMass (Da)Tools
A7IH09 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 5003963727618FCB

FASTA45747,359
        10         20         30         40         50         60 
MRHHRLTPQR DPAMATASAA RTDVSAVAGR SVPPVEGGAD LAAYMSDMGR RARAASRTLA 

        70         80         90        100        110        120 
LTPPEAKTQA LHAAAAAIRA AADEILAANA GDVAKAKADG MTGSFLDRLT LTPARIAAMA 

       130        140        150        160        170        180 
EGVEQVAALS DPVGEVTESW TRPNGLKIER VRTPLGVIGV IYESRPNVTA DAAALCLRAG 

       190        200        210        220        230        240 
NAVILRGGSD SIASSGAIHR AFVSGLKSAG LPEDAVQFVA VADRAAVGLM LAGLDNNMDV 

       250        260        270        280        290        300 
IVPRGGKSLV ARVQSDARVP VFAHLDGINH VYVDKAADLD MAKTVVLNAK MRRTGVCGAA 

       310        320        330        340        350        360 
ETLLVDQAVA ATHLKPLVEM LIDAGCEVRG DEAVQAVDGR VKPATPLDWD TEYLDAIIAA 

       370        380        390        400        410        420 
KVVDGLAGAV AHIEAHGSHH TDSIVTEDVA TAERFLAEVD SAIVLHNAST QFADGGEFGF 

       430        440        450 
GGEIGIATGR MHARGPVGAE QLTSFKYRIH GSGQTRP

« Hide

References

[1]"Complete sequence of chromosome of Xanthobacter autotrophicus Py2."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000781 Genomic DNA. Translation: ABS67302.1.
RefSeqYP_001416959.1. NC_009720.1.

3D structure databases

ProteinModelPortalA7IH09.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7IH09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5423047.
GenomeReviewsGene locus Xaut_2058 in contig CP000781_GR.
KEGGxau:Xaut_2058.
PATRIC24046195. VBIXanAut29526_2387.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0014.
HOGENOMHBG318080.
OMAYGICGAM.
ProtClustDBPRK00197.

Enzyme and pathway databases

BioCycXAUT78245:XAUT_2058-MONOMER.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7IH09_XANP2
AccessionPrimary (citable) accession number: A7IH09
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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