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A7IGW4

- ASSY_XANP2

UniProt

A7IGW4 - ASSY_XANP2

Protein

Argininosuccinate synthase

Gene

argG

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei91 – 911CitrullineUniRule annotation
    Binding sitei96 – 961CitrullineUniRule annotation
    Binding sitei121 – 1211ATP; via amide nitrogenUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei127 – 1271AspartateUniRule annotation
    Binding sitei127 – 1271CitrullineUniRule annotation
    Binding sitei128 – 1281AspartateUniRule annotation
    Binding sitei131 – 1311CitrullineUniRule annotation
    Binding sitei182 – 1821CitrullineUniRule annotation
    Binding sitei191 – 1911CitrullineUniRule annotation
    Binding sitei267 – 2671CitrullineUniRule annotation
    Binding sitei279 – 2791CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 199ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciXAUT78245:GHS6-2035-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Xaut_2013
    OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
    Taxonomic identifieri78245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
    ProteomesiUP000002417: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Argininosuccinate synthasePRO_1000089061Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi78245.Xaut_2013.

    Structurei

    3D structure databases

    ProteinModelPortaliA7IGW4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7IGW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARDVKKVVL AYSGGLDTSV ILKWLQTTYK CEVITFTADL GQGEELEPAR    50
    KKAQLLGIKD ENIFIEDVRE EFVAEYVFPM FRANAVYEGL YLLGTSIARP 100
    LIAKKQIEIA RKMGADAVSH GATGKGNDQV RFELGYYALE PEITVIAPWR 150
    EWDLTSRTRL LEFAEQHQIP IAKDKRGEAP FSVDANLLHS SSEGKVLEDP 200
    AEDAPEYVYQ RTISPEAAPD EPTIITIAFD KGDAVAINGE ALSPATLLTK 250
    LNELGKANGI GRLDLVENRF VGMKSRGVYE TPGGTILLAA HRGIESITLD 300
    RGAAHLKDEL MPRYAELIYN GFWFSPEREM LQAAIDHSQA YVTGEVTVKL 350
    YKGNTTVIGR KSPYSLYNQE LVTFEEGAVA YDHRDAAGFI KLNALRLRTL 400
    GSRARKISE 409
    Length:409
    Mass (Da):45,389
    Last modified:September 11, 2007 - v1
    Checksum:i872C12ABFBDCFC7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000781 Genomic DNA. Translation: ABS67257.1.
    RefSeqiYP_001416914.1. NC_009720.1.

    Genome annotation databases

    EnsemblBacteriaiABS67257; ABS67257; Xaut_2013.
    GeneIDi5421127.
    KEGGixau:Xaut_2013.
    PATRICi24046101. VBIXanAut29526_2340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000781 Genomic DNA. Translation: ABS67257.1 .
    RefSeqi YP_001416914.1. NC_009720.1.

    3D structure databases

    ProteinModelPortali A7IGW4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 78245.Xaut_2013.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS67257 ; ABS67257 ; Xaut_2013 .
    GeneIDi 5421127.
    KEGGi xau:Xaut_2013.
    PATRICi 24046101. VBIXanAut29526_2340.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci XAUT78245:GHS6-2035-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1158 / Py2.

    Entry informationi

    Entry nameiASSY_XANP2
    AccessioniPrimary (citable) accession number: A7IGW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3