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A7IGM0

- RBL_XANP2

UniProt

A7IGM0 - RBL_XANP2

Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei128 – 1281Substrate; in homodimeric partnerUniRule annotation
    Binding sitei178 – 1781SubstrateUniRule annotation
    Active sitei180 – 1801Proton acceptorUniRule annotation
    Binding sitei182 – 1821SubstrateUniRule annotation
    Metal bindingi206 – 2061Magnesium; via carbamate groupUniRule annotation
    Metal bindingi208 – 2081MagnesiumUniRule annotation
    Metal bindingi209 – 2091MagnesiumUniRule annotation
    Active sitei298 – 2981Proton acceptorUniRule annotation
    Binding sitei299 – 2991SubstrateUniRule annotation
    Binding sitei331 – 3311SubstrateUniRule annotation
    Sitei338 – 3381Transition state stabilizerUniRule annotation
    Binding sitei383 – 3831SubstrateUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. monooxygenase activity Source: UniProtKB-KW
    3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. reductive pentose-phosphate cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase, Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Calvin cycle, Carbon dioxide fixation

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciXAUT78245:GHS6-1940-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCO large subunitUniRule annotation
    Gene namesi
    Name:cbbLUniRule annotation
    Ordered Locus Names:Xaut_1918
    OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
    Taxonomic identifieri78245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
    ProteomesiUP000002417: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Ribulose bisphosphate carboxylase large chainPRO_1000142753Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei206 – 2061N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi78245.Xaut_1918.

    Structurei

    3D structure databases

    ProteinModelPortaliA7IGM0.
    SMRiA7IGM0. Positions 26-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1850.
    HOGENOMiHOG000230831.
    KOiK01601.
    OMAiFTQDWAS.
    OrthoDBiEOG6ZKXMS.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPiMF_01338. RuBisCO_L_type1.
    InterProiIPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7IGM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGADAAIGQI KDAKKRYAAG VLKYAQMGYW DGDYQPKDTD VLALFRITPQ    50
    DGVDAVEAAA AVAGESSTAT WTVVWTDRLT AADMYRAKAY KVEPVPGQPG 100
    QYFCWVAYDL DLFEEGSIAN LTASIIGNVF SFKPLKACRL EDMRLPVAYV 150
    KTFRGPPTGI VVERERLDKF GRPLLGATTK PKLGLSGKNY GRVVYEGLKG 200
    GLDFVKDDEN INSQPFMHWR DRFLYCMEAV NKAQAETGEV KGHYLNITAG 250
    TMEEMYRRAE FAKELGSVVV MVDLIVGWTA IQSISNWCRE NDVLLHMHRA 300
    GHGTYTRQKG HGISFRVIAK WLRLAGVDHL HTGTAVGKLE GDPMTVQGYY 350
    NVCRETVTKT DYTRGIFFDQ DWAGLRKVMP VASGGIHAGQ MHQLIDLFGE 400
    DVVLQFGGGT IGHPDGIQAG AIANRVALET MILARNEGRD IKNEGPEILI 450
    EAAKWCRPLR AALDTWGEVT FNYASTDTSD FVPTASVA 488
    Length:488
    Mass (Da):53,824
    Last modified:September 11, 2007 - v1
    Checksum:i58FCD8DDBCBE6386
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000781 Genomic DNA. Translation: ABS67163.1.
    RefSeqiWP_012113941.1. NC_009720.1.
    YP_001416820.1. NC_009720.1.

    Genome annotation databases

    EnsemblBacteriaiABS67163; ABS67163; Xaut_1918.
    GeneIDi5424516.
    KEGGixau:Xaut_1918.
    PATRICi24045907. VBIXanAut29526_2243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000781 Genomic DNA. Translation: ABS67163.1 .
    RefSeqi WP_012113941.1. NC_009720.1.
    YP_001416820.1. NC_009720.1.

    3D structure databases

    ProteinModelPortali A7IGM0.
    SMRi A7IGM0. Positions 26-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 78245.Xaut_1918.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS67163 ; ABS67163 ; Xaut_1918 .
    GeneIDi 5424516.
    KEGGi xau:Xaut_1918.
    PATRICi 24045907. VBIXanAut29526_2243.

    Phylogenomic databases

    eggNOGi COG1850.
    HOGENOMi HOG000230831.
    KOi K01601.
    OMAi FTQDWAS.
    OrthoDBi EOG6ZKXMS.

    Enzyme and pathway databases

    BioCyci XAUT78245:GHS6-1940-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPi MF_01338. RuBisCO_L_type1.
    InterProi IPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1158 / Py2.

    Entry informationi

    Entry nameiRBL_XANP2
    AccessioniPrimary (citable) accession number: A7IGM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3