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Protein

Fructose-1,6-bisphosphatase class 1 1

Gene

fbp1

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi115Magnesium 1UniRule annotation1
Metal bindingi134Magnesium 1UniRule annotation1
Metal bindingi134Magnesium 2UniRule annotation1
Metal bindingi136Magnesium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi137Magnesium 2UniRule annotation1
Binding sitei228SubstrateUniRule annotation1
Metal bindingi300Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase class 1 1UniRule annotation (EC:3.1.3.11UniRule annotation)
Short name:
FBPase class 1 1UniRule annotation
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1UniRule annotation
Gene namesi
Name:fbp1UniRule annotation
Ordered Locus Names:Xaut_1915
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
Proteomesi
  • UP000002417 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003647481 – 371Fructose-1,6-bisphosphatase class 1 1Add BLAST371

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi78245.Xaut_1915.

Structurei

3D structure databases

ProteinModelPortaliA7IGL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 140Substrate bindingUniRule annotation4
Regioni280 – 282Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the FBPase class 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZI. Bacteria.
COG0158. LUCA.
HOGENOMiHOG000191264.
KOiK03841.
OMAiTLDRTDN.
OrthoDBiPOG091H05DB.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IGL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTRRTGRAE KTLRETTAMP TADHRAAPGI TLACALEEWA GEDARRRDVA
60 70 80 90 100
ATLNALAAGT IQIARAIAEG PLAGDLARTL SSGEAGEGQK ALDIISNDMV
110 120 130 140 150
IDALRKAPVA AVASEENDAP VLLDPEAPLL VAIDPLDGSS NIDTDISVGT
160 170 180 190 200
IFAVFPHQDG TDAASVTAFL QNGRDMLAGG YVIYGPHTAL MLTVGAGTWH
210 220 230 240 250
FALDRDGSFR LVNAAVRVKE DAAEFAINMS NYHHWDDPIR AYVDDCLAGR
260 270 280 290 300
KGPREREFNM RWVASMVADA HRIFQRGGIY LYPGDGRKGY THGRLRLLYE
310 320 330 340 350
AFPVAFLMEQ AQGSAIDGRS SILDLSATGV HQRVPFIFGS RDEVARAARY
360 370
HLEPSGHGER SPLFARRGLF I
Length:371
Mass (Da):40,094
Last modified:September 11, 2007 - v1
Checksum:i95EC62EAEB0044FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000781 Genomic DNA. Translation: ABS67160.1.

Genome annotation databases

EnsemblBacteriaiABS67160; ABS67160; Xaut_1915.
KEGGixau:Xaut_1915.
PATRICi24045901. VBIXanAut29526_2240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000781 Genomic DNA. Translation: ABS67160.1.

3D structure databases

ProteinModelPortaliA7IGL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi78245.Xaut_1915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS67160; ABS67160; Xaut_1915.
KEGGixau:Xaut_1915.
PATRICi24045901. VBIXanAut29526_2240.

Phylogenomic databases

eggNOGiENOG4105CZI. Bacteria.
COG0158. LUCA.
HOGENOMiHOG000191264.
KOiK03841.
OMAiTLDRTDN.
OrthoDBiPOG091H05DB.

Enzyme and pathway databases

UniPathwayiUPA00138.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF16A1_XANP2
AccessioniPrimary (citable) accession number: A7IGL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.