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A7IFX5 (A7IFX5_XANP2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase 2 HAMAP MF_01517
EC=1.1.1.37 HAMAP MF_01517
Gene names
Name:mdh2 HAMAP MF_01517
Ordered Locus Names:Xaut_1673
OrganismXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]
Taxonomic identifier78245 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517 SAAS SAAS010945

Subunit structure

Homodimer By similarity. HAMAP MF_01517 SAAS SAAS010945

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. HAMAP MF_01517

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 187NAD By similarity HAMAP MF_01517
Nucleotide binding130 – 1323NAD By similarity HAMAP MF_01517

Sites

Active site1881Proton acceptor By similarity HAMAP MF_01517
Binding site931Substrate By similarity HAMAP MF_01517
Binding site991Substrate By similarity HAMAP MF_01517
Binding site1061NAD By similarity HAMAP MF_01517
Binding site1131NAD By similarity HAMAP MF_01517
Binding site1321Substrate By similarity HAMAP MF_01517
Binding site1631Substrate By similarity HAMAP MF_01517

Sequences

Sequence LengthMass (Da)Tools
A7IFX5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: AA3D33536D571464

FASTA32734,679
        10         20         30         40         50         60 
MTKPAVRVAV TGAAGQICYS LLFRIANGDM YGKDQPVILQ LLDLPQAQAA VGGVVMELED 

        70         80         90        100        110        120 
CAFPNLAGVV ITDDPKVAFK DIDAAVLVGA RPRSKGMERA DLLSANAEIF KVQGKALNEV 

       130        140        150        160        170        180 
AKRDVKVLVV GNPANTNAYI TAKSAPDLPA KNITAMLRLD HNRALSQFAA KAGIATADIE 

       190        200        210        220        230        240 
KVAVWGNHSP TMYADYRFAT ANGKPLPELI NDETWYRETL LPKVGKRGAA IIEARGLSSA 

       250        260        270        280        290        300 
ASAANAAVDH MHDWIHGTDG KWVSMGVASD GSYGVPEGIV FGVPAVCSGG EYEVVKGLPM 

       310        320 
DDFSKAMFEK TLNELLEERD GVAALLG

« Hide

References

[1]"Complete sequence of chromosome of Xanthobacter autotrophicus Py2."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000781 Genomic DNA. Translation: ABS66918.1.
RefSeqYP_001416575.1. NC_009720.1.

3D structure databases

ProteinModelPortalA7IFX5.
SMRA7IFX5. Positions 3-325.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7IFX5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5424545.
GenomeReviewsGene locus Xaut_1673 in contig CP000781_GR.
KEGGxau:Xaut_1673.
PATRIC24045377. VBIXanAut29526_1984.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHBG289884.
OMADPNVAFK.
ProtClustDBPRK05442.

Enzyme and pathway databases

BioCycXAUT78245:XAUT_1673-MONOMER.

Family and domain databases

HAMAPMF_01517. Malate_dehydrog_2.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00024.
PANTHERPTHR23382. MDH_SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA7IFX5_XANP2
AccessionPrimary (citable) accession number: A7IFX5
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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