A7ICA9 (HIS8_XANP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	Xaut_0394

Organism

Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) [Complete proteome] [HAMAP]

Taxonomic identifier

78245 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Xanthobacteraceae › Xanthobacter

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000135432
Amino acid modifications
	Modified residue	236	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7ICA9 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 43E0727C78F7CBDA	FASTA	392	41,607
	10 20 30 40 50 60 MSAVLKDPIP APGRPESTRP EPRPGVLAIE AYVPGKSHAP GVEKVFKLSS NETPLGPSEK 70 80 90 100 110 120 AVAAFAEAGR KLEDYPDGSA TVLRQAIATA YGLDPARIIC GAGSDEILNL VAHTYVGPGD 130 140 150 160 170 180 EVIFSEHGFL VYKIATLASG GTPVVARERD LTADVDAILA LVTPRTRLVF LANPNNPTGT 190 200 210 220 230 240 YLPFDEVRRL HAGLPANVLL VLDAAYAEYV RRNDYETGLE LALTADNVLM SRTFSKIHGL 250 260 270 280 290 300 AALRIGWAVG PAHVIDAMNR VRGPFNMNTP ALLAGAAAIA DAAHVEKAVA HNARWLPWLT 310 320 330 340 350 360 EQIEGLGLKV TPSVANFLLI HFPDTPGRTA KEADAFLMKR GLVLRQVASY GLPHALRMTV 370 380 390 GTEEANHLVV AALADFMSGN SSAGQEAGGK DK

References

[1]

"Complete sequence of chromosome of Xanthobacter autotrophicus Py2." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Brainard J., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1158 / Py2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000781 Genomic DNA. Translation: ABS65652.1.
RefSeq	YP_001415309.1. NC_009720.1.
3D structure databases
ProteinModelPortal	A7ICA9.
ModBase	Search...
Protein-protein interaction databases
STRING	A7ICA9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5423457.
GenomeReviews	Gene locus Xaut_0394 in contig CP000781_GR.
KEGG	xau:Xaut_0394.
PATRIC	24042763. VBIXanAut29526_0690.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	YAYANDA.
ProtClustDB	PRK02731.
Enzyme and pathway databases
BioCyc	XAUT78245:XAUT_0394-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_XANP2

Accession

Primary (citable) accession number: A7ICA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program