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A7IC03

- PNP_XANP2

UniProt

A7IC03 - PNP_XANP2

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Xaut_0288
Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi489 – 4891Magnesium By similarity
Metal bindingi495 – 4951Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciXAUT78245:GHS6-290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Xaut_0288
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
ProteomesiUP000002417: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000192506Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi78245.Xaut_0288.

Structurei

3D structure databases

ProteinModelPortaliA7IC03.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini556 – 61560KH
Add
BLAST
Domaini625 – 69369S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IC03-1 [UniParc]FASTAAdd to Basket

« Hide

MFDIHREELD WGGRTLTLET GKMARQADGS VLATYGDTKV LATVVSAREP    50
KPGQDFFPLT VNYQEKTYAA GRIPGGYFKR EGRPSEKETL VSRLIDRPIR 100
PLFPEGYKCD TQVVITVLAH DLENDPDVVA MVAASAALTL SGVPFMGPVG 150
AARVGFIDNE YVLNPTVDEV KESALELVVA GTGDAVLMVE SEAKELPEEI 200
MLGAVMFGHR HFQPVIEAII KLAEKAAKEP RNFQPADVSE VESKVREIAE 250
ADLRAAYKIK QKQDRYAAVG AAKSKVKKYY EELALDGTKV PTAQVVSDVL 300
KALEAKIVRW NILDDGIRID GRDVYTVRPI VSEVGILPRA HGSALFTRGE 350
TQALVVATLG TGEDEQFIDS LEGTYKEHFL LHYNFPPFSV GETGRMGSPG 400
RREIGHGKLA WRAIHPMLPA KHEFPYTLRV VSEILESNGS SSMATVCGTS 450
LALMDAGVPL RRPVAGIAMG LILEGEKFAV LSDILGDEDH LGDMDFKVAG 500
TEQGVTSLQM DIKIAGITEE IMKVALTQAK DGRVHILGEM AKALTTARAE 550
LGEHAPRIEV MKIAVDKIRE VIGSGGKVIR EIVEKTGAKI NIEDDGTIKI 600
ASASGDAIKA AINWIKSIAS EPEVGQIYEG TVVKVVDFGA FVNFFGSKDG 650
LVHVSQMANE RVAKPSDVVK EGDKVKVKLM GFDERGKTRL SMKVVDQTTG 700
EDLEAKAKAE RDAARAAAPA ATGDEAGAAE 730
Length:730
Mass (Da):78,913
Last modified:September 11, 2007 - v1
Checksum:i898AB6D7939526D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS65546.1.
RefSeqiYP_001415203.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaiABS65546; ABS65546; Xaut_0288.
GeneIDi5422788.
KEGGixau:Xaut_0288.
PATRICi24042543. VBIXanAut29526_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000781 Genomic DNA. Translation: ABS65546.1 .
RefSeqi YP_001415203.1. NC_009720.1.

3D structure databases

ProteinModelPortali A7IC03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 78245.Xaut_0288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS65546 ; ABS65546 ; Xaut_0288 .
GeneIDi 5422788.
KEGGi xau:Xaut_0288.
PATRICi 24042543. VBIXanAut29526_0580.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci XAUT78245:GHS6-290-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1158 / Py2.

Entry informationi

Entry nameiPNP_XANP2
AccessioniPrimary (citable) accession number: A7IC03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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