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A7IC03

- PNP_XANP2

UniProt

A7IC03 - PNP_XANP2

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi489 – 4891MagnesiumUniRule annotation
    Metal bindingi495 – 4951MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciXAUT78245:GHS6-290-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Xaut_0288
    OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
    Taxonomic identifieri78245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
    ProteomesiUP000002417: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 730730Polyribonucleotide nucleotidyltransferasePRO_1000192506Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi78245.Xaut_0288.

    Structurei

    3D structure databases

    ProteinModelPortaliA7IC03.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini556 – 61560KHUniRule annotationAdd
    BLAST
    Domaini625 – 69369S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218327.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7IC03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFDIHREELD WGGRTLTLET GKMARQADGS VLATYGDTKV LATVVSAREP    50
    KPGQDFFPLT VNYQEKTYAA GRIPGGYFKR EGRPSEKETL VSRLIDRPIR 100
    PLFPEGYKCD TQVVITVLAH DLENDPDVVA MVAASAALTL SGVPFMGPVG 150
    AARVGFIDNE YVLNPTVDEV KESALELVVA GTGDAVLMVE SEAKELPEEI 200
    MLGAVMFGHR HFQPVIEAII KLAEKAAKEP RNFQPADVSE VESKVREIAE 250
    ADLRAAYKIK QKQDRYAAVG AAKSKVKKYY EELALDGTKV PTAQVVSDVL 300
    KALEAKIVRW NILDDGIRID GRDVYTVRPI VSEVGILPRA HGSALFTRGE 350
    TQALVVATLG TGEDEQFIDS LEGTYKEHFL LHYNFPPFSV GETGRMGSPG 400
    RREIGHGKLA WRAIHPMLPA KHEFPYTLRV VSEILESNGS SSMATVCGTS 450
    LALMDAGVPL RRPVAGIAMG LILEGEKFAV LSDILGDEDH LGDMDFKVAG 500
    TEQGVTSLQM DIKIAGITEE IMKVALTQAK DGRVHILGEM AKALTTARAE 550
    LGEHAPRIEV MKIAVDKIRE VIGSGGKVIR EIVEKTGAKI NIEDDGTIKI 600
    ASASGDAIKA AINWIKSIAS EPEVGQIYEG TVVKVVDFGA FVNFFGSKDG 650
    LVHVSQMANE RVAKPSDVVK EGDKVKVKLM GFDERGKTRL SMKVVDQTTG 700
    EDLEAKAKAE RDAARAAAPA ATGDEAGAAE 730
    Length:730
    Mass (Da):78,913
    Last modified:September 11, 2007 - v1
    Checksum:i898AB6D7939526D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000781 Genomic DNA. Translation: ABS65546.1.
    RefSeqiYP_001415203.1. NC_009720.1.

    Genome annotation databases

    EnsemblBacteriaiABS65546; ABS65546; Xaut_0288.
    GeneIDi5422788.
    KEGGixau:Xaut_0288.
    PATRICi24042543. VBIXanAut29526_0580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000781 Genomic DNA. Translation: ABS65546.1 .
    RefSeqi YP_001415203.1. NC_009720.1.

    3D structure databases

    ProteinModelPortali A7IC03.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 78245.Xaut_0288.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS65546 ; ABS65546 ; Xaut_0288 .
    GeneIDi 5422788.
    KEGGi xau:Xaut_0288.
    PATRICi 24042543. VBIXanAut29526_0580.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218327.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci XAUT78245:GHS6-290-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1158 / Py2.

    Entry informationi

    Entry nameiPNP_XANP2
    AccessioniPrimary (citable) accession number: A7IC03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3