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Protein

Malate dehydrogenase

Gene

mdh

Organism
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Xaut_0153
OrganismiXanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
Taxonomic identifieri78245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeXanthobacter
Proteomesi
  • UP000002417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001261511 – 321Malate dehydrogenaseAdd BLAST321

Interactioni

Protein-protein interaction databases

STRINGi78245.Xaut_0153.

Structurei

3D structure databases

ProteinModelPortaliA7IBL9.
SMRiA7IBL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiICIIANP.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR11540:SF31. PTHR11540:SF31. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A7IBL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNKIALIG AGQIGGTLAL LAGMKALGDI VLFDVAEGVP EGKALDLAEL
60 70 80 90 100
TPVEGFDAAY AGASSYDAIS GADVVIVTAG VARKPGMSRD DLLAINLKVM
110 120 130 140 150
EQVGAGIRKY APDAFVICIT NPLDAMVWAL QRSSGLPPEK VVGMAGVLDS
160 170 180 190 200
ARLRYFLAEE FGVSVEDVTA FVMGGHGDTM VPLVRYSTVG GIPVPDLIRM
210 220 230 240 250
GWTSEERIAA IVQRTRDGGA EIVNLLKSGS AFYAPAASAI AMAESYLRDK
260 270 280 290 300
KRVLPVAALL DGEYGLRDIY VGVPAVIGAR GVERIVEVEL DRSERAMFDR
310 320
SVAAVEGLVE ACLKIAPGLG K
Length:321
Mass (Da):33,664
Last modified:September 11, 2007 - v1
Checksum:iE6DAFF8A89026D1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000781 Genomic DNA. Translation: ABS65412.1.
RefSeqiWP_011995831.1. NC_009720.1.

Genome annotation databases

EnsemblBacteriaiABS65412; ABS65412; Xaut_0153.
KEGGixau:Xaut_0153.

Similar proteinsi

Entry informationi

Entry nameiMDH_XANP2
AccessioniPrimary (citable) accession number: A7IBL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 11, 2007
Last modified: August 30, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families