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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381ZincUniRule annotation
Metal bindingi41 – 411ZincUniRule annotation
Metal bindingi57 – 571ZincUniRule annotation
Metal bindingi60 – 601ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 6532TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-2365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:Mboo_2311
OrganismiMethanoregula boonei (strain 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Transcription initiation factor IIBPRO_1000080107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_2311.

Structurei

3D structure databases

ProteinModelPortaliA7IAR4.
SMRiA7IAR4. Positions 138-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati151 – 234841Add
BLAST
Repeati245 – 326822Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation
Contains 1 TFIIB-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 6532TFIIB-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IAR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEVEKLKLL QSEREALKSR IKVKEQEKKA ENHTETVCPE CGGRQLVHDY
60 70 80 90 100
ERAELVCQSC GLVIDDDFID RGPEWRAFDH DQRMKRSRVG APMTFTIHDK
110 120 130 140 150
GLSTMIDWRN RDSYGRAISS KNRAQLYRLR KWQRRIRVSN ATERNLAFAL
160 170 180 190 200
SELDRMASAL GLPRNVRETA AVVYRDAVDK NLIRGRSIEG VAAAALYAAC
210 220 230 240 250
RQCSVPRTLD EIAEVSRVSR KEIGRTYRFI SRELGLKLLP TSPIDYVPRF
260 270 280 290 300
CSGLTLKGEV QSRAVEILRQ AGERELTSGR GPTGVAAAAI YISSILGGER
310 320 330
RTQREVAEVA GVTEVTIRNR YKELAEKLDI EIIL
Length:334
Mass (Da):37,847
Last modified:September 11, 2007 - v1
Checksum:iA6C45EFF371AF499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS56825.1.
RefSeqiYP_001405468.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS56825; ABS56825; Mboo_2311.
GeneIDi5409810.
KEGGimbn:Mboo_2311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS56825.1.
RefSeqiYP_001405468.1. NC_009712.1.

3D structure databases

ProteinModelPortaliA7IAR4.
SMRiA7IAR4. Positions 138-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi456442.Mboo_2311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS56825; ABS56825; Mboo_2311.
GeneIDi5409810.
KEGGimbn:Mboo_2311.

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-2365-MONOMER.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8.

Entry informationi

Entry nameiTF2B_METB6
AccessioniPrimary (citable) accession number: A7IAR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: March 4, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.