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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei162GTPUniRule annotation1
Binding sitei166GTPUniRule annotation1
Binding sitei209GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi131 – 133GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOO456442:G1G9N-2402-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:Mboo_2265Imported
OrganismiMethanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)Imported
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
Proteomesi
  • UP000002408 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi456442.Mboo_2265

Structurei

3D structure databases

ProteinModelPortaliA7IAL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 227TubulinInterPro annotationAdd BLAST192
Domaini229 – 346Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit

Sequencei

Sequence statusi: Complete.

A7IAL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSIVEEALT KARDETASSP QNNEDLDQIL SELKTEITVI GCGGSGSNTV
60 70 80 90 100
TRMMEEGIHG AKLVAINTDA QHLIRTHADQ RILIGRQRTR GLGAGSIPQI
110 120 130 140 150
GEEAALENEQ DIKAIVSGCD MVFITVGLGG GTGTGSAPVV AKAAREEGAL
160 170 180 190 200
TIAVVTLPFA SEGAIRMENA EAGLERLRDV ADTVIVVPND RLLEVVPKLP
210 220 230 240 250
LSAAFKVSDE VLMRAVKGIT ELITMPGLVN LDFADVRTVM ERGGVAMIGM
260 270 280 290 300
GESDSEDKAA DSVKKAIRSP LLDVDISGAT AALVNVVGGP DMTMAEAEGV
310 320 330 340 350
VQEVYSRVDE NARIIWGAQV DPTMSNKMRT LLVVTGVRSP QIYGRNEKLT
360
PKVQKQYEID FLK
Length:363
Mass (Da):38,674
Last modified:September 11, 2007 - v1
Checksum:i12C12E45B201ED27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA Translation: ABS56779.1
RefSeqiWP_012107839.1, NC_009712.1

Genome annotation databases

EnsemblBacteriaiABS56779; ABS56779; Mboo_2265
GeneIDi5411082
KEGGimbn:Mboo_2265

Similar proteinsi

Entry informationi

Entry nameiA7IAL8_METB6
AccessioniPrimary (citable) accession number: A7IAL8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health