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A7IAG1

- SYE_METB6

UniProt

A7IAG1 - SYE_METB6

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-2258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Mboo_2208
OrganismiMethanoregula boonei (strain 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Glutamate--tRNA ligasePRO_0000367803Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_2208.

Structurei

3D structure databases

ProteinModelPortaliA7IAG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi108 – 11811"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiAFRIIDT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 2 hits.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IAG1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGDEIKAAL FLCALQNAVR HGGVPQAGAV IGMVMGAHPE LRKQAKEVSA
60 70 80 90 100
AAKDAIADVA ALSPEERVTK LQSLSPEMFA ALHEKHEKKK VLPDLEGAEH
110 120 130 140 150
GVVMRFAPNP SGPLHIGHAR AAALNDAYVK QYGGRYILRI EDTDPKRVDP
160 170 180 190 200
EAYDMVKEDI AWMGLGITET VTQSERFPIY YDLCKQLIER GGAYVCTCEN
210 220 230 240 250
EHFKALKDAK KACPCRDQPV ETALLLWEKM LNGGFKEGEA SVRVKTDLLN
260 270 280 290 300
PDPAMRDYPI FRILDAPLHP KIGDARVYPL MNFSVVADDH LLGVTHVIRG
310 320 330 340 350
KDHIANTRRQ RYIYDHFGWK VPVYRHYGRM GIEGVVLSTS QMHAGIDEGK
360 370 380 390 400
YTGWDDIHLG TLRALARRGI SPDAVKNAMI AIGIGDVDIS FSWDNLYAEN
410 420 430 440 450
KKIVDPVANR YFFVPDPLEA KIAGASAHTA HAMLHPGHEE KGTRTLEFTG
460 470 480 490 500
TVLIPRAEIF SVIVSSLNDI SQGGDYESPQ AKISSENVSP ITSINEKKES
510 520 530 540 550
VHSDNLPKLE GSLSSSLNDR KLVPRKYEPK REITMLRLKD LFNVNITWDG
560 570 580 590 600
ETPSFSYGGD SLADARAAKA RIIQWLPAQS FVPCTLLTQD GEMKGACEPA
610 620 630
VTTEVGKVVQ FERIAFARID AVTESGVRAY FTHT
Length:634
Mass (Da):70,004
Last modified:September 11, 2007 - v1
Checksum:iE7C84D1F5ED80F7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS56722.1.
RefSeqiYP_001405365.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS56722; ABS56722; Mboo_2208.
GeneIDi5411228.
KEGGimbn:Mboo_2208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS56722.1 .
RefSeqi YP_001405365.1. NC_009712.1.

3D structure databases

ProteinModelPortali A7IAG1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456442.Mboo_2208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS56722 ; ABS56722 ; Mboo_2208 .
GeneIDi 5411228.
KEGGi mbn:Mboo_2208.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi AFRIIDT.

Enzyme and pathway databases

BioCyci MBOO456442:GH2T-2258-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 2 hits.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8.

Entry informationi

Entry nameiSYE_METB6
AccessioniPrimary (citable) accession number: A7IAG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3