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A7IAG1

- SYE_METB6

UniProt

A7IAG1 - SYE_METB6

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Protein
Glutamate--tRNA ligase
Gene
gltX, Mboo_2208
Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-2258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:Mboo_2208
OrganismiMethanoregula boonei (strain 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Glutamate--tRNA ligaseUniRule annotation
PRO_0000367803Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_2208.

Structurei

3D structure databases

ProteinModelPortaliA7IAG1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi108 – 11811"HIGH" regionUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiAFRIIDT.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 2 hits.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IAG1-1 [UniParc]FASTAAdd to Basket

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MAGDEIKAAL FLCALQNAVR HGGVPQAGAV IGMVMGAHPE LRKQAKEVSA    50
AAKDAIADVA ALSPEERVTK LQSLSPEMFA ALHEKHEKKK VLPDLEGAEH 100
GVVMRFAPNP SGPLHIGHAR AAALNDAYVK QYGGRYILRI EDTDPKRVDP 150
EAYDMVKEDI AWMGLGITET VTQSERFPIY YDLCKQLIER GGAYVCTCEN 200
EHFKALKDAK KACPCRDQPV ETALLLWEKM LNGGFKEGEA SVRVKTDLLN 250
PDPAMRDYPI FRILDAPLHP KIGDARVYPL MNFSVVADDH LLGVTHVIRG 300
KDHIANTRRQ RYIYDHFGWK VPVYRHYGRM GIEGVVLSTS QMHAGIDEGK 350
YTGWDDIHLG TLRALARRGI SPDAVKNAMI AIGIGDVDIS FSWDNLYAEN 400
KKIVDPVANR YFFVPDPLEA KIAGASAHTA HAMLHPGHEE KGTRTLEFTG 450
TVLIPRAEIF SVIVSSLNDI SQGGDYESPQ AKISSENVSP ITSINEKKES 500
VHSDNLPKLE GSLSSSLNDR KLVPRKYEPK REITMLRLKD LFNVNITWDG 550
ETPSFSYGGD SLADARAAKA RIIQWLPAQS FVPCTLLTQD GEMKGACEPA 600
VTTEVGKVVQ FERIAFARID AVTESGVRAY FTHT 634
Length:634
Mass (Da):70,004
Last modified:September 11, 2007 - v1
Checksum:iE7C84D1F5ED80F7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS56722.1.
RefSeqiYP_001405365.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS56722; ABS56722; Mboo_2208.
GeneIDi5411228.
KEGGimbn:Mboo_2208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS56722.1 .
RefSeqi YP_001405365.1. NC_009712.1.

3D structure databases

ProteinModelPortali A7IAG1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 456442.Mboo_2208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS56722 ; ABS56722 ; Mboo_2208 .
GeneIDi 5411228.
KEGGi mbn:Mboo_2208.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi AFRIIDT.

Enzyme and pathway databases

BioCyci MBOO456442:GH2T-2258-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 2 hits.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8.

Entry informationi

Entry nameiSYE_METB6
AccessioniPrimary (citable) accession number: A7IAG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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