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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOO456442:G1G9N-2332-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mboo_2198
OrganismiMethanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
Proteomesi
  • UP000002408 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987531 – 2142-phospho-L-lactate guanylyltransferaseAdd BLAST214

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi456442.Mboo_2198

Structurei

3D structure databases

ProteinModelPortaliA7IAF1
SMRiA7IAF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472 Archaea
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiFRVDYHG
OrthoDBiPOG093Z0CT7

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

A7IAF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPHALIPFK PAGPKSRLSG ILSPEEREAF ARAMLEDVIA AARDANCSPV
60 70 80 90 100
IVATELFDSE DVQITIADKD LSGTLNEVLS QAAGPVLILM ADLPLATGPA
110 120 130 140 150
IKRVASTTSD IGIVPGRGGG TNAIFVREPA KFHVDYYGMS FLKHIRIAQE
160 170 180 190 200
AGLSCEVIDS FLLHTDIDEE DDLVELLTHG SGKSRKYLED LGFVLSAENG
210
RVGVKRPVQP APAT
Length:214
Mass (Da):22,834
Last modified:September 11, 2007 - v1
Checksum:iFFBEE87653C2E4A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA Translation: ABS56712.1
RefSeqiWP_012107772.1, NC_009712.1

Genome annotation databases

EnsemblBacteriaiABS56712; ABS56712; Mboo_2198
GeneIDi5410984
KEGGimbn:Mboo_2198

Similar proteinsi

Entry informationi

Entry nameiCOFC_METB6
AccessioniPrimary (citable) accession number: A7IAF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 11, 2007
Last modified: February 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health