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A7IAA9

- DNLI_METB6

UniProt

A7IAA9 - DNLI_METB6

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Protein
DNA ligase
Gene
lig, Mboo_2156
Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441ATP By similarity
Active sitei246 – 2461N6-AMP-lysine intermediate By similarity
Binding sitei251 – 2511ATP By similarity
Binding sitei266 – 2661ATP By similarity
Binding sitei295 – 2951ATP By similarity
Binding sitei334 – 3341ATP By similarity
Binding sitei405 – 4051ATP By similarity
Binding sitei411 – 4111ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-2201-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:Mboo_2156
OrganismiMethanoregula boonei (strain 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550DNA ligaseUniRule annotation
PRO_0000365256Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_2156.

Structurei

3D structure databases

ProteinModelPortaliA7IAA9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IAA9-1 [UniParc]FASTAAdd to Basket

« Hide

MLFSEFAQVC EELEHLSGRL DMIEVISRAL PDLAPDELPV FVRFVMGRIF    50
PDWSAQKLGI GPNLLYEAVR QAAGVKLETV ITRINQQGDV GRAVEDILAK 100
KTQVSWSHQD LELVYVYNKL TGISSRGGVT SQKEKIRIAM LLLGDASPLE 150
GRYLARIMLE ELRIGVGEGT VREAIAKAFM VDSALVEHAM QAINDLGEVA 200
RLAKKGPTAL SDVHITPFHP VKMMLAQQGT IAGMIEDHGE IAAEYKYDGS 250
RFQFHKEGAK ARMYSRRLED VSEALPDVID LLSKATSHDV ILDGEVIAIK 300
DDRPMPFQSV LRRFRRRHDI AEAQEAIRMV PNVFDILYLD GETLIDLPFF 350
ERRKKLETVV GKFVAPQVVS TDPQTIEQTY HDALAAGHEG IMLKVPASPY 400
TPGQRGKNWI KIKPEVDTLD LAVIGAEWGE GKRAHVFGSF LVACQDQGKL 450
IPLSRVATGF SDEQLTEVYD LLKDAVISRT GKEVRFEPEL VFEVGYAELQ 500
VSPTYDAGFA LRFPRFIRIR DDKDTTEIET LESIRGRYQR QAKSAQAYTK 550
Length:550
Mass (Da):61,583
Last modified:September 11, 2007 - v1
Checksum:i9029C3918A446474
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS56670.1.
RefSeqiYP_001405313.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS56670; ABS56670; Mboo_2156.
GeneIDi5410132.
KEGGimbn:Mboo_2156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS56670.1 .
RefSeqi YP_001405313.1. NC_009712.1.

3D structure databases

ProteinModelPortali A7IAA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456442.Mboo_2156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS56670 ; ABS56670 ; Mboo_2156 .
GeneIDi 5410132.
KEGGi mbn:Mboo_2156.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MBOO456442:GH2T-2201-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8.

Entry informationi

Entry nameiDNLI_METB6
AccessioniPrimary (citable) accession number: A7IAA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi