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A7IAA9

- DNLI_METB6

UniProt

A7IAA9 - DNLI_METB6

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Protein

DNA ligase

Gene

lig

Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441ATPUniRule annotation
Active sitei246 – 2461N6-AMP-lysine intermediateUniRule annotation
Binding sitei251 – 2511ATPUniRule annotation
Binding sitei266 – 2661ATPUniRule annotation
Binding sitei295 – 2951ATPUniRule annotation
Binding sitei334 – 3341ATPUniRule annotation
Binding sitei405 – 4051ATPUniRule annotation
Binding sitei411 – 4111ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-2201-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mboo_2156
OrganismiMethanoregula boonei (strain 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550DNA ligasePRO_0000365256Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_2156.

Structurei

3D structure databases

ProteinModelPortaliA7IAA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7IAA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFSEFAQVC EELEHLSGRL DMIEVISRAL PDLAPDELPV FVRFVMGRIF
60 70 80 90 100
PDWSAQKLGI GPNLLYEAVR QAAGVKLETV ITRINQQGDV GRAVEDILAK
110 120 130 140 150
KTQVSWSHQD LELVYVYNKL TGISSRGGVT SQKEKIRIAM LLLGDASPLE
160 170 180 190 200
GRYLARIMLE ELRIGVGEGT VREAIAKAFM VDSALVEHAM QAINDLGEVA
210 220 230 240 250
RLAKKGPTAL SDVHITPFHP VKMMLAQQGT IAGMIEDHGE IAAEYKYDGS
260 270 280 290 300
RFQFHKEGAK ARMYSRRLED VSEALPDVID LLSKATSHDV ILDGEVIAIK
310 320 330 340 350
DDRPMPFQSV LRRFRRRHDI AEAQEAIRMV PNVFDILYLD GETLIDLPFF
360 370 380 390 400
ERRKKLETVV GKFVAPQVVS TDPQTIEQTY HDALAAGHEG IMLKVPASPY
410 420 430 440 450
TPGQRGKNWI KIKPEVDTLD LAVIGAEWGE GKRAHVFGSF LVACQDQGKL
460 470 480 490 500
IPLSRVATGF SDEQLTEVYD LLKDAVISRT GKEVRFEPEL VFEVGYAELQ
510 520 530 540 550
VSPTYDAGFA LRFPRFIRIR DDKDTTEIET LESIRGRYQR QAKSAQAYTK
Length:550
Mass (Da):61,583
Last modified:September 11, 2007 - v1
Checksum:i9029C3918A446474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS56670.1.
RefSeqiYP_001405313.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS56670; ABS56670; Mboo_2156.
GeneIDi5410132.
KEGGimbn:Mboo_2156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS56670.1 .
RefSeqi YP_001405313.1. NC_009712.1.

3D structure databases

ProteinModelPortali A7IAA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456442.Mboo_2156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS56670 ; ABS56670 ; Mboo_2156 .
GeneIDi 5410132.
KEGGi mbn:Mboo_2156.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MBOO456442:GH2T-2201-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8.

Entry informationi

Entry nameiDNLI_METB6
AccessioniPrimary (citable) accession number: A7IAA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3