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A7IAA9

- DNLI_METB6

UniProt

A7IAA9 - DNLI_METB6

Protein

DNA ligase

Gene

lig

Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei244 – 2441ATPUniRule annotation
    Active sitei246 – 2461N6-AMP-lysine intermediateUniRule annotation
    Binding sitei251 – 2511ATPUniRule annotation
    Binding sitei266 – 2661ATPUniRule annotation
    Binding sitei295 – 2951ATPUniRule annotation
    Binding sitei334 – 3341ATPUniRule annotation
    Binding sitei405 – 4051ATPUniRule annotation
    Binding sitei411 – 4111ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMBOO456442:GH2T-2201-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mboo_2156
    OrganismiMethanoregula boonei (strain 6A8)
    Taxonomic identifieri456442 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
    ProteomesiUP000002408: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550DNA ligasePRO_0000365256Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi456442.Mboo_2156.

    Structurei

    3D structure databases

    ProteinModelPortaliA7IAA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7IAA9-1 [UniParc]FASTAAdd to Basket

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    MLFSEFAQVC EELEHLSGRL DMIEVISRAL PDLAPDELPV FVRFVMGRIF    50
    PDWSAQKLGI GPNLLYEAVR QAAGVKLETV ITRINQQGDV GRAVEDILAK 100
    KTQVSWSHQD LELVYVYNKL TGISSRGGVT SQKEKIRIAM LLLGDASPLE 150
    GRYLARIMLE ELRIGVGEGT VREAIAKAFM VDSALVEHAM QAINDLGEVA 200
    RLAKKGPTAL SDVHITPFHP VKMMLAQQGT IAGMIEDHGE IAAEYKYDGS 250
    RFQFHKEGAK ARMYSRRLED VSEALPDVID LLSKATSHDV ILDGEVIAIK 300
    DDRPMPFQSV LRRFRRRHDI AEAQEAIRMV PNVFDILYLD GETLIDLPFF 350
    ERRKKLETVV GKFVAPQVVS TDPQTIEQTY HDALAAGHEG IMLKVPASPY 400
    TPGQRGKNWI KIKPEVDTLD LAVIGAEWGE GKRAHVFGSF LVACQDQGKL 450
    IPLSRVATGF SDEQLTEVYD LLKDAVISRT GKEVRFEPEL VFEVGYAELQ 500
    VSPTYDAGFA LRFPRFIRIR DDKDTTEIET LESIRGRYQR QAKSAQAYTK 550
    Length:550
    Mass (Da):61,583
    Last modified:September 11, 2007 - v1
    Checksum:i9029C3918A446474
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000780 Genomic DNA. Translation: ABS56670.1.
    RefSeqiYP_001405313.1. NC_009712.1.

    Genome annotation databases

    EnsemblBacteriaiABS56670; ABS56670; Mboo_2156.
    GeneIDi5410132.
    KEGGimbn:Mboo_2156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000780 Genomic DNA. Translation: ABS56670.1 .
    RefSeqi YP_001405313.1. NC_009712.1.

    3D structure databases

    ProteinModelPortali A7IAA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 456442.Mboo_2156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS56670 ; ABS56670 ; Mboo_2156 .
    GeneIDi 5410132.
    KEGGi mbn:Mboo_2156.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MBOO456442:GH2T-2201-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 6A8.

    Entry informationi

    Entry nameiDNLI_METB6
    AccessioniPrimary (citable) accession number: A7IAA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3