Skip Header

Contribute Send feedback
Read comments (?) or add your own

A7IA92 (GUAAB_METB6) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] subunit B

EC=6.3.5.2
Alternative name(s):
GMP synthetase
Gene names
Name:guaAB
Ordered Locus Names:Mboo_2139
OrganismMethanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]
Taxonomic identifier456442 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesGenera incertae sedisMethanoregula

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00345

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00345

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00345

Subunit structure

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential.

Sequence similarities

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.

Ontologies

Keywords
   Biological processGMP biosynthesis
Purine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processGMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GMP synthase (glutamine-hydrolyzing) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305GMP synthase [glutamine-hydrolyzing] subunit B HAMAP MF_00345
PRO_1000048375

Regions

Domain2 – 184183GMPS ATP-PPase
Nucleotide binding29 – 357ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7IA92 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: C1DF31A53C83A2D7

FASTA30533,434
        10         20         30         40         50         60 
MVKTEKFIQK SVEEIQKEAG NEKVVMALSG GVDSSVCASL AARAIGDRLI PIYIDTGLMR 

        70         80         90        100        110        120 
KGETERIKAV FGNIRLQVVD AGDEFVAALA GITDPEKKRK AIGERFIRVF EREAKKSGAT 

       130        140        150        160        170        180 
CLLQGTIYPD RIESEGGIKS HHNVGGMPEH TAFKKVIEPI RDLYKDEVRE VAGALGLPPE 

       190        200        210        220        230        240 
IQHRMPFPGP GLAVRILGEV TKEKVAVIRE ANWIAESEIV EKYRPWQCFA ALIGLGTGVK 

       250        260        270        280        290        300 
GDNRIHGWIV AVRAVNSRDG MTADPLEIPF ADLVRIGSRI TAEIPSVARV VYDITPKPPA 


TIEYE 

« Hide

References

[1]"Complete sequence of Candidatus Methanoregula boonei 6A8."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 6A8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000780 Genomic DNA. Translation: ABS56653.1.
RefSeqYP_001405296.1. NC_009712.1.

3D structure databases

ProteinModelPortalA7IA92.
SMRA7IA92. Positions 4-305.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7IA92.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5409957.
GenomeReviewsGene locus Mboo_2139 in contig CP000780_GR.
KEGGmbn:Mboo_2139.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04539.
HOGENOMHBG391775.
OMAQGTIAPD.
ProtClustDBPRK00919.

Enzyme and pathway databases

BioCycCMET456442:MBOO_2139-MONOMER.

Family and domain databases

HAMAPMF_00345. GMP_synthase_B.
[Tree]
InterProIPR001674. GMP_synth_C.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
PROSITEPS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAAB_METB6
AccessionPrimary (citable) accession number: A7IA92
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families