Reviewed,
UniProtKB/Swiss-Prot A7IA92 (GUAAB_METB6)
Last modified
February 9, 2010.
Version 18.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: GMP synthase [glutamine-hydrolyzing] subunit B EC=6.3.5.2 Alternative name(s): GMP synthetase | ||||
| Gene names |
| ||||
| Organism | Methanoregula boonei (strain 6A8) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 456442 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Candidatus Methanoregula |
Protein attributes
| Sequence length | 305 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00345 |
| Catalytic activity | ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00345 |
| Pathway | Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00345 |
| Subunit structure | Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential. HAMAP MF_00345 |
| Sequence similarities | Contains 1 GMP-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | GMP biosynthesis Purine biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | GMP biosynthetic process Inferred from electronic annotation. Source: HAMAP NAD biosynthetic processInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP GMP synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 305 | 305 | GMP synthase [glutamine-hydrolyzing] subunit B HAMAP MF_00345 | PRO_1000048375 | |||||
Regions | |||||||||
| Domain | 33 – 185 | 153 | GMP-binding | ||||||
| Nucleotide binding | 29 – 35 | 7 | ATP By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence of Candidatus Methanoregula boonei 6A8." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. Richardson P.Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000780 Genomic DNA. Translation: ABS56653.1. |
| RefSeq | YP_001405296.1. |
3D structure databases | |
| SMR | A7IA92. Positions 4-305. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A7IA92. |
Genome annotation databases | |
| GeneID | 5409957. |
| GenomeReviews | Gene locus Mboo_2139 in contig CP000780_GR. |
| KEGG | mbn:Mboo_2139. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | arNOG04539. |
| HOGENOM | HBG391775. |
| OMA | GIKSHHN. |
Family and domain databases | |
| HAMAP | MF_00345. GMP_synthase_B. [Tree] |
| InterPro | IPR001674. GMP_synth_C. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits. |
| Pfam | PF00958. GMP_synt_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00884. guaA_Cterm. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | GUAAB_METB6 | ||||||||
| Accession | Primary (citable) accession number: A7IA92 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


