SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7IA08

- THIM_METB6

UniProt

A7IA08 - THIM_METB6

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hydroxyethylthiazole kinase

Gene
thiM, Mboo_2055
Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate; via amide nitrogen By similarity
Binding sitei121 – 1211ATP By similarity
Binding sitei167 – 1671ATP By similarity
Binding sitei194 – 1941Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-2099-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:Mboo_2055
OrganismiMethanoregula boonei (strain 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Hydroxyethylthiazole kinaseUniRule annotationPRO_1000021519Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_2055.

Structurei

3D structure databases

ProteinModelPortaliA7IA08.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

A7IA08-1 [UniParc]FASTAAdd to Basket

« Hide

MDNQVFSGIF ARAREQHPLV HHITNYVTVN DCANITIGAG GAPVMADARE    50
EAGEMTGFAG ALVLNIGTLN SGIIESMILA GKVANERKIP IILDPVGAGA 100
TRLRTDSTRR LLDELTISII KGNAGEIGVL AGAEAKVRGV DSAGISGDPV 150
TITRTFARET GITVVMSGAT DIISDGNKVL LVDNGHPLMG RISGTGCMAS 200
AVTGVIAAVE KDRLIAAATA LAAFGLAGER AAAASRGPGS FKPALFDAMA 250
ELGPQDLAAD ARVRSA 266
Length:266
Mass (Da):27,142
Last modified:September 11, 2007 - v1
Checksum:i075B6F87F7D05204
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS56569.1.
RefSeqiYP_001405212.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS56569; ABS56569; Mboo_2055.
GeneIDi5410688.
KEGGimbn:Mboo_2055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS56569.1 .
RefSeqi YP_001405212.1. NC_009712.1.

3D structure databases

ProteinModelPortali A7IA08.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456442.Mboo_2055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS56569 ; ABS56569 ; Mboo_2055 .
GeneIDi 5410688.
KEGGi mbn:Mboo_2055.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci MBOO456442:GH2T-2099-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8.

Entry informationi

Entry nameiTHIM_METB6
AccessioniPrimary (citable) accession number: A7IA08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi