A7I9M0 (HIS3_METB6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	Mboo_1916

Organism

Methanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]

Taxonomic identifier

456442 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Methanoregula

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 123	123	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_0000319732

Sequences

	Sequence		Length	Mass (Da)
	A7I9M0 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: F064FF07091BB731	FASTA	123	14,006
	10 20 30 40 50 60 MLPLKFHEGG LIPVIVQDQK TREVLMMAYA NEEAVRLTES TGSAHYYSRS RKKIWKKGEE 70 80 90 100 110 120 SGHFQKVGRI LVDCDEDCLI YEVEQTGAAC HTGYRTCFYR TLDGVTIGEK IFDPEKVYGK TGH

References

[1]

"Complete sequence of Candidatus Methanoregula boonei 6A8." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 6A8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000780 Genomic DNA. Translation: ABS56431.1.
RefSeq	YP_001405074.1. NC_009712.1.
3D structure databases
ProteinModelPortal	A7I9M0.
SMR	A7I9M0. Positions 3-114.
ModBase	Search...
Protein-protein interaction databases
STRING	A7I9M0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5410114.
GenomeReviews	Gene locus Mboo_1916 in contig CP000780_GR.
KEGG	mbn:Mboo_1916.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12274.
HOGENOM	HBG294308.
OMA	GACHVGY.
ProtClustDB	CLSK949737.
Enzyme and pathway databases
BioCyc	CMET456442:MBOO_1916-MONOMER.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
KO	K01496.
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_METB6

Accession

Primary (citable) accession number: A7I9M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 11, 2007
Last modified:	November 16, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program