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Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

Mboo_1843

Organism
Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandMagnesium

Enzyme and pathway databases

BioCyciMBOO456442:G1G9N-1954-MONOMER
UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.42UniRule annotation)
Short name:
DGGGP synthaseUniRule annotation
Short name:
DGGGPSUniRule annotation
Alternative name(s):
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Geranylgeranylglycerol-phosphate geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Mboo_1843
OrganismiMethanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
Proteomesi
  • UP000002408 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Transmembranei127 – 147HelicalUniRule annotationAdd BLAST21
Transmembranei148 – 168HelicalUniRule annotationAdd BLAST21
Transmembranei198 – 218HelicalUniRule annotationAdd BLAST21
Transmembranei219 – 239HelicalUniRule annotationAdd BLAST21
Transmembranei259 – 279HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003507081 – 279Digeranylgeranylglyceryl phosphate synthaseAdd BLAST279

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_1843

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG00476 Archaea
COG0382 LUCA
HOGENOMiHOG000152645
KOiK17105
OMAiALIIMND
OrthoDBiPOG093Z0AHF

Family and domain databases

HAMAPiMF_01286 DGGGP_synth, 1 hit
InterProiView protein in InterPro
IPR023547 DGGGP_synth
IPR000537 UbiA_prenyltransferase
PfamiView protein in Pfam
PF01040 UbiA, 1 hit

Sequencei

Sequence statusi: Complete.

A7I9E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRGFFAIT RPANSVVAGL AAIVAYLIAT GTLVYGVLLL MAVVLLVTAA
60 70 80 90 100
GNVINDYFDA AIDTINRPDR PIPSGAVSRN AALAWAFSLF LLGLAVSVFT
110 120 130 140 150
TPLCMGIALV NALLLVLYAA RLKSTPFFGN AAVAFLSASI FLFGGAYAGW
160 170 180 190 200
HALLDMLPIA AITFLAMLAR ELLKDAEDIE GDRAHGADTL AIRIGVRKTA
210 220 230 240 250
LIAFACTAFA IAASAVPYLW WGGWYLAGIA AVDLVILFAA GRSLGCTDPV
260 270
SLKATGSTTL LKLGMFASLV VFTLSAVFL
Length:279
Mass (Da):29,096
Last modified:September 11, 2007 - v1
Checksum:i6C11F747D346144D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA Translation: ABS56358.1
RefSeqiWP_012107409.1, NC_009712.1

Genome annotation databases

EnsemblBacteriaiABS56358; ABS56358; Mboo_1843
GeneIDi5411844
KEGGimbn:Mboo_1843

Similar proteinsi

Entry informationi

Entry nameiDGGGP_METB6
AccessioniPrimary (citable) accession number: A7I9E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health