ID   A7I956_METB6            Unreviewed;       283 AA.
AC   A7I956;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000313|EMBL:ABS56267.1};
DE            EC=1.1.1.133 {ECO:0000313|EMBL:ABS56267.1};
GN   OrderedLocusNames=Mboo_1750 {ECO:0000313|EMBL:ABS56267.1};
OS   Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX   NCBI_TaxID=456442 {ECO:0000313|EMBL:ABS56267.1, ECO:0000313|Proteomes:UP000002408};
RN   [1] {ECO:0000313|Proteomes:UP000002408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21154 / JCM 14090 / 6A8
RC   {ECO:0000313|Proteomes:UP000002408};
RX   PubMed=25998264; DOI=10.1099/mic.0.000117;
RA   Braeuer S., Cadillo-Quiroz H., Kyrpides N., Woyke T., Goodwin L.,
RA   Detter C., Podell S., Yavitt J.B., Zinder S.H.;
RT   "Genome of Methanoregula boonei 6A8 reveals adaptations to oligotrophic
RT   peatland environments.";
RL   Microbiology 161:1572-1581(2015).
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DR   EMBL; CP000780; ABS56267.1; -; Genomic_DNA.
DR   RefSeq; WP_012107315.1; NC_009712.1.
DR   AlphaFoldDB; A7I956; -.
DR   STRING; 456442.Mboo_1750; -.
DR   GeneID; 5409911; -.
DR   KEGG; mbn:Mboo_1750; -.
DR   eggNOG; arCOG01367; Archaea.
DR   HOGENOM; CLU_045518_1_2_2; -.
DR   OrthoDB; 4907at2157; -.
DR   Proteomes; UP000002408; Chromosome.
DR   GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR   CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029903; RmlD-like-bd.
DR   NCBIfam; TIGR01214; rmlD; 1.
DR   PANTHER; PTHR10491; DTDP-4-DEHYDRORHAMNOSE REDUCTASE; 1.
DR   PANTHER; PTHR10491:SF4; METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA; 1.
DR   Pfam; PF04321; RmlD_sub_bind; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:ABS56267.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002408}.
FT   DOMAIN          1..279
FT                   /note="RmlD-like substrate binding"
FT                   /evidence="ECO:0000259|Pfam:PF04321"
SQ   SEQUENCE   283 AA;  31510 MW;  1186955AE4F974DC CRC64;
     MRVLITGVNG QLGQDIRKVC EQNSIDHIAT GSKELNISNV SEVQHFVKKN PVDVIINCAA
     YNAVDLAETE WKKAYRVNGL GVRNLATAAN SLGAVFVHFS TDYVFDGKSR LPYTIADLPR
     PISRYGMSKL LGETMTRDIA DTFILIRTSW VFGKGNDNFP KKIMGWSKNK TELKVVDDQV
     ASPTYTADLA KATLDLILKN ARGMYHITNS GYCSRYEWAE FLLAKVGWKG NLVRGSSDEF
     MSAAQRPAYS VLDNFGTPEC LGYSLPDWKD ATERFLQDLE AVS
//