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A7I8R6 (F16PA_METB6) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Gene names
Name:fbp
Ordered Locus Names:Mboo_1610
OrganismMethanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]
Taxonomic identifier456442 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Methanoregula

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855

Subunit structure

Homotetramer By similarity. HAMAP MF_01855

Subcellular location

Cytoplasm Potential HAMAP MF_01855.

Sequence similarities

Belongs to the FBPase class 1 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855
PRO_0000364774

Regions

Region104 – 1074Substrate binding By similarity

Sites

Metal binding811Magnesium 1 By similarity
Metal binding1011Magnesium 1 By similarity
Metal binding1011Magnesium 2 By similarity
Metal binding1031Magnesium 1; via carbonyl oxygen By similarity
Metal binding1041Magnesium 2 By similarity
Metal binding2461Magnesium 2 By similarity
Binding site2401Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A7I8R6 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 4030F12B5F1CF365

FASTA30033,081
        10         20         30         40         50         60 
MILREFLDKE GTEKNLAELI LFLSGQAREV KKGFLSTCMN TGACGTQNMF GEDQKPLDKY 

        70         80         90        100        110        120 
ADDVFIHALQ KSRLVRYIAT EEQDHVIEVS GAKNQFGVVI DPLDGSSLLD VNLCVGSIIG 

       130        140        150        160        170        180 
IYPGHVLEKG TKMIAALYML YGPLTLLTFT TKHGVHEFVQ CETGEFVLRH ENLKIPEGKI 

       190        200        210        220        230        240 
QSPGALRRDY LTAHAQWISC LENEGYKLRF SGCFVADVHQ ILHKGGVFSY PGYKGKESGK 

       250        260        270        280        290        300 
LRLLYEANPM GMIVCEAGGA ASNGHTDYRE IVPSAIGQVT PLYIGGKKEI AKIESCMREG

« Hide

References

[1]"Complete sequence of Candidatus Methanoregula boonei 6A8."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 6A8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000780 Genomic DNA. Translation: ABS56127.1.
RefSeqYP_001404770.1. NC_009712.1.

3D structure databases

ProteinModelPortalA7I8R6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7I8R6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5412205.
GenomeReviewsGene locus Mboo_1610 in contig CP000780_GR.
KEGGmbn:Mboo_1610.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG06461.
HOGENOMHBG731261.
OMAQLWDDKL.
ProtClustDBCLSK949627.

Enzyme and pathway databases

BioCycCMET456442:MBOO_1610-MONOMER.

Family and domain databases

HAMAPMF_01855. FBPase_class1.
[Tree]
InterProIPR000146. FBPase_class-1/SBPase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
KOK03841.
PANTHERPTHR11556. In_FB_phphtase. 1 hit.
PfamPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFPIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSPR00115. F16BPHPHTASE.
PROSITEPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF16PA_METB6
AccessionPrimary (citable) accession number: A7I8R6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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