A7I8M6 (AROD_METB6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	Mboo_1570

Organism

Methanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]

Taxonomic identifier

456442 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Methanoregula

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325537
Sites
	Active site	109	1	Proton acceptor By similarity
	Active site	134	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7I8M6 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: F9090862BB1835DD	FASTA	209	22,841
	10 20 30 40 50 60 MQIVASLTDP SQAATAQSQG ADLLELRFDL MEGDPVDIAR RCRAISKLPL IATFRSALEG 70 80 90 100 110 120 GRYFGSPEEW AKKIAPVLPL VDYVDIEQQF ARKSGLVREA GKAIIASHHT AEMLPLHVLF 130 140 150 160 170 180 VLEQELRAYG DIPKIIVTPH NEDELIDLIA FTRAAKKPVC TGVMGSAFRY ARAILPLFGS 190 200 ELAYCHAGVP AAEGQYSVAE FVALMKMLS

References

[1]

"Complete sequence of Candidatus Methanoregula boonei 6A8." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 6A8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000780 Genomic DNA. Translation: ABS56087.1.
RefSeq	YP_001404730.1. NC_009712.1.
3D structure databases
ProteinModelPortal	A7I8M6.
ModBase	Search...
Protein-protein interaction databases
STRING	A7I8M6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5410095.
GenomeReviews	Gene locus Mboo_1570 in contig CP000780_GR.
KEGG	mbn:Mboo_1570.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12575.
HOGENOM	HBG541552.
OMA	PICTSIM.
ProtClustDB	CLSK949565.
Enzyme and pathway databases
BioCyc	CMET456442:MBOO_1570-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_METB6

Accession

Primary (citable) accession number: A7I8M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	September 11, 2007
Last modified:	November 16, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program