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A7I8L8 (AROA_METB6) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:Mboo_1562
OrganismMethanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]
Taxonomic identifier456442 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Methanoregula

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_1000099716

Sequences

Sequence LengthMass (Da)Tools
A7I8L8 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 9E477976B8AFA48E

FASTA42144,380
        10         20         30         40         50         60 
MIVTLPARSG IELSVTTPPS KSYTHRALIA AALAQGRSTI VRPLMADDTK LTIASLMKLG 

        70         80         90        100        110        120 
VAIHADQHNI MLEGCDGSFP NTPGTVLDLD NSGTSLRLLA SAALLATYPV TLTGSARMQE 

       130        140        150        160        170        180 
RPLGPLAHTL NDLGGMVIFT KKEGYPPVTI GGRLLGGTAT IDGSQSSQFA SSVMMAAPYS 

       190        200        210        220        230        240 
KGPVDLTVTG TPASQSYLDI TAGVMTDFGA VIRREGYRRF LVSNCNHYTG RTFVVEGDYS 

       250        260        270        280        290        300 
SASYFFALAA ICGGKVTVAG LAPDSVQGDR LFLDALQRMG CEVTYAHDGV TVENQGPLTG 

       310        320        330        340        350        360 
ITINMSSAPD TVQTLCMVAA VARTPTIITG IGHLKFKESD RIAVTADRLR MLGGIVTAER 

       370        380        390        400        410        420 
DRIVIQPATL HGGRIDPVND HRTAMSFAVL GLGIGGITIT GAECVNKSFP GFWEILSKVM 


E

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References

[1]"Complete sequence of Candidatus Methanoregula boonei 6A8."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 6A8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000780 Genomic DNA. Translation: ABS56079.1.
RefSeqYP_001404722.1. NC_009712.1.

3D structure databases

ProteinModelPortalA7I8L8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7I8L8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5410087.
GenomeReviewsGene locus Mboo_1562 in contig CP000780_GR.
KEGGmbn:Mboo_1562.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG05032.
HOGENOMHBG646626.
OMAGADIEWG.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycCMET456442:MBOO_1562-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. False negative.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_METB6
AccessionPrimary (citable) accession number: A7I8L8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: November 16, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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