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A7I809

- NADK_METB6

UniProt

A7I809 - NADK_METB6

Protein

NAD kinase

Gene

nadK

Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631Proton acceptorUniRule annotation
    Binding sitei68 – 681NADUniRule annotation
    Binding sitei142 – 1421NADUniRule annotation
    Binding sitei159 – 1591NADUniRule annotation
    Binding sitei161 – 1611NADUniRule annotation
    Binding sitei196 – 1961NAD; via carbonyl oxygenUniRule annotation
    Binding sitei230 – 2301NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 642NADUniRule annotation
    Nucleotide bindingi131 – 1322NADUniRule annotation
    Nucleotide bindingi172 – 1776NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMBOO456442:GH2T-1378-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Mboo_1352
    OrganismiMethanoregula boonei (strain 6A8)
    Taxonomic identifieri456442 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
    ProteomesiUP000002408: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270NAD kinasePRO_1000059877Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi456442.Mboo_1352.

    Structurei

    3D structure databases

    ProteinModelPortaliA7I809.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiPRKTKFV.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7I809-1 [UniParc]FASTAAdd to Basket

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    MKCFLVSRID MPGALDCASR MKTALERAGH TVVLDPDTAS MLGGSGHSIN    50
    KVSADMAVVI GGDGTILRTV QQLHEQIPII GINHGEVGFL ADLEPEEAGA 100
    FVRSLAPGFD VEERMRLSLW NEEDHLGDAL NEGLIVTTRP AKMLRFSILV 150
    DGRLTEQFRS DGILVSTPTG STAYAMSAGG PIVDPRIEGF LLVPLAPYLL 200
    SSRPHLISSS RRLEIRLESS KPAKLVIDGQ NTVELGSAVS LVIQKAASPA 250
    RFIDVHRNFF EKVDRKLRKL 270
    Length:270
    Mass (Da):29,305
    Last modified:September 11, 2007 - v1
    Checksum:i562E4D3C53D6301D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000780 Genomic DNA. Translation: ABS55870.1.
    RefSeqiWP_012106903.1. NC_009712.1.
    YP_001404513.1. NC_009712.1.

    Genome annotation databases

    EnsemblBacteriaiABS55870; ABS55870; Mboo_1352.
    GeneIDi5410288.
    KEGGimbn:Mboo_1352.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000780 Genomic DNA. Translation: ABS55870.1 .
    RefSeqi WP_012106903.1. NC_009712.1.
    YP_001404513.1. NC_009712.1.

    3D structure databases

    ProteinModelPortali A7I809.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 456442.Mboo_1352.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS55870 ; ABS55870 ; Mboo_1352 .
    GeneIDi 5410288.
    KEGGi mbn:Mboo_1352.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi PRKTKFV.

    Enzyme and pathway databases

    BioCyci MBOO456442:GH2T-1378-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 6A8.

    Entry informationi

    Entry nameiNADK_METB6
    AccessioniPrimary (citable) accession number: A7I809
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3