A7I7P3 (A7I7P3_METB6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

Mboo_1236

Organism

Methanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]

Taxonomic identifier

456442 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Methanoregula

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515 PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL ABS55754.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	198	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	251	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	118	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	120	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	128	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	236	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	208	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	220	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	276	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	315	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A7I7P3 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 18AEF5D5D80475D0	FASTA	325	34,997
	10 20 30 40 50 60 MFPTRRMRRV RSRTIQPLLC ETTISKNDLV APLFVDETAS APVPISSMPG QFRYPVSGIA 70 80 90 100 110 120 AVVQKFRDRG IRAVLLFGIP AHKDEGATAA YDPQGVVQQA VRNIKAACPD MLVITDVCAC 130 140 150 160 170 180 EYTSHGHCGI VGDSRCSGPD LLNDESLLLM NKIATSHAEA GADIVAPSCM LDGMVGSIRA 190 200 210 220 230 240 ALDTAGYEEV LILSYSTKFS SALYGPFREA AESGFSFGDR TTYQMNPANG REAFLESQLD 250 260 270 280 290 300 ADEGADILMV KPAGPYLDVL ADVATLGLPV AAYQVSGEYS MIKAAAERGW IKEKETVLET 310 320 LTCIKRAGAD LIITYFAYDV CGWLS

References

[1]

"Complete sequence of Candidatus Methanoregula boonei 6A8." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 6A8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000780 Genomic DNA. Translation: ABS55754.1.
RefSeq	YP_001404397.1. NC_009712.1.
3D structure databases
ProteinModelPortal	A7I7P3.
ModBase	Search...
Protein-protein interaction databases
STRING	A7I7P3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5409920.
GenomeReviews	Gene locus Mboo_1236 in contig CP000780_GR.
KEGG	mbn:Mboo_1236.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05029.
HOGENOM	HBG285270.
OMA	ADLCFCE.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A7I7P3_METB6

Accession

Primary (citable) accession number: A7I7P3

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)