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A7I7B2

- A7I7B2_METB6

UniProt

A7I7B2 - A7I7B2_METB6

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, Mboo_1105
Organism
Methanoregula boonei (strain 6A8)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptor By similarityUniRule annotation
Binding sitei154 – 1541Substrate By similarityUniRule annotation
Metal bindingi178 – 1781Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi180 – 1801Magnesium By similarityUniRule annotation
Metal bindingi181 – 1811Magnesium By similarityUniRule annotation
Active sitei270 – 2701Proton acceptor By similarityUniRule annotation
Binding sitei271 – 2711Substrate By similarityUniRule annotation
Binding sitei303 – 3031Substrate By similarityUniRule annotation
Sitei310 – 3101Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-1125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Mboo_1105Imported
OrganismiMethanoregula boonei (strain 6A8)Imported
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi456442.Mboo_1105.

Structurei

3D structure databases

ProteinModelPortaliA7I7B2.
SMRiA7I7B2. Positions 3-428.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni353 – 3553Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1850.
HOGENOMiHOG000230831.
KOiK01601.
OMAiMSIFKGV.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7I7B2-1 [UniParc]FASTAAdd to Basket

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MAIDWYNEFV DPNYKPANDD LVCLFYFEPA AGITDKEAAG RIASESSTGT    50
WTTLATLPPR MKKLEAKAFE FDGHYVKVAY PLALWEEGNA VQLLSGIAGN 100
IFGMKALKNL RLIDATLPSA YTREFKGPHF GMDGIRKMMG IRGRPLTGAV 150
PKPKIGFSAK EHAEIGYETW MGGFDFVKDD ENLTSTSFNR FDDRVKYMTK 200
LRDKAEKETG EKKSAFLNIS ADVETMKKRA DLLVEYGWNY AMIDVVVAGT 250
ASVMTMRDYC SDLGLAIHAH RAFHSAFDRN KKHGMTMYFL AKLMRLIGVS 300
QIHTGTAVGK LTGTKTESIL LADLLRKQKI QEVSHQCLAQ DWGTIKTAFP 350
VSSGGLHPGL VPDVLDIYGT DLVLLVSGGI HGHPKGTRAG AKATMQAIEA 400
WQEGITLDEK AKKAKELKEA LAKWGYYKPK 430
Length:430
Mass (Da):47,589
Last modified:September 11, 2007 - v1
Checksum:i834A25FF1F256C45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS55623.1.
RefSeqiYP_001404266.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS55623; ABS55623; Mboo_1105.
GeneIDi5411265.
KEGGimbn:Mboo_1105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS55623.1 .
RefSeqi YP_001404266.1. NC_009712.1.

3D structure databases

ProteinModelPortali A7I7B2.
SMRi A7I7B2. Positions 3-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456442.Mboo_1105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS55623 ; ABS55623 ; Mboo_1105 .
GeneIDi 5411265.
KEGGi mbn:Mboo_1105.

Phylogenomic databases

eggNOGi COG1850.
HOGENOMi HOG000230831.
KOi K01601.
OMAi MSIFKGV.

Enzyme and pathway databases

BioCyci MBOO456442:GH2T-1125-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8Imported.

Entry informationi

Entry nameiA7I7B2_METB6
AccessioniPrimary (citable) accession number: A7I7B2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi