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A7I7B2

- A7I7B2_METB6

UniProt

A7I7B2 - A7I7B2_METB6

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Methanoregula boonei (strain 6A8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Note: Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptorUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Metal bindingi178 – 1781Magnesium; via carbamate groupUniRule annotation
Metal bindingi180 – 1801MagnesiumUniRule annotation
Metal bindingi181 – 1811MagnesiumUniRule annotation
Active sitei270 – 2701Proton acceptorUniRule annotation
Binding sitei271 – 2711SubstrateUniRule annotation
Binding sitei303 – 3031SubstrateUniRule annotation
Sitei310 – 3101Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-1125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Mboo_1105Imported
OrganismiMethanoregula boonei (strain 6A8)Imported
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Protein-protein interaction databases

STRINGi456442.Mboo_1105.

Structurei

3D structure databases

ProteinModelPortaliA7I7B2.
SMRiA7I7B2. Positions 3-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni353 – 3553Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation
Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1850.
HOGENOMiHOG000230831.
KOiK01601.
OMAiMSIFKGV.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7I7B2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIDWYNEFV DPNYKPANDD LVCLFYFEPA AGITDKEAAG RIASESSTGT
60 70 80 90 100
WTTLATLPPR MKKLEAKAFE FDGHYVKVAY PLALWEEGNA VQLLSGIAGN
110 120 130 140 150
IFGMKALKNL RLIDATLPSA YTREFKGPHF GMDGIRKMMG IRGRPLTGAV
160 170 180 190 200
PKPKIGFSAK EHAEIGYETW MGGFDFVKDD ENLTSTSFNR FDDRVKYMTK
210 220 230 240 250
LRDKAEKETG EKKSAFLNIS ADVETMKKRA DLLVEYGWNY AMIDVVVAGT
260 270 280 290 300
ASVMTMRDYC SDLGLAIHAH RAFHSAFDRN KKHGMTMYFL AKLMRLIGVS
310 320 330 340 350
QIHTGTAVGK LTGTKTESIL LADLLRKQKI QEVSHQCLAQ DWGTIKTAFP
360 370 380 390 400
VSSGGLHPGL VPDVLDIYGT DLVLLVSGGI HGHPKGTRAG AKATMQAIEA
410 420 430
WQEGITLDEK AKKAKELKEA LAKWGYYKPK
Length:430
Mass (Da):47,589
Last modified:September 11, 2007 - v1
Checksum:i834A25FF1F256C45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS55623.1.
RefSeqiYP_001404266.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS55623; ABS55623; Mboo_1105.
GeneIDi5411265.
KEGGimbn:Mboo_1105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS55623.1 .
RefSeqi YP_001404266.1. NC_009712.1.

3D structure databases

ProteinModelPortali A7I7B2.
SMRi A7I7B2. Positions 3-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456442.Mboo_1105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS55623 ; ABS55623 ; Mboo_1105 .
GeneIDi 5411265.
KEGGi mbn:Mboo_1105.

Phylogenomic databases

eggNOGi COG1850.
HOGENOMi HOG000230831.
KOi K01601.
OMAi MSIFKGV.

Enzyme and pathway databases

BioCyci MBOO456442:GH2T-1125-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8Imported.

Entry informationi

Entry nameiA7I7B2_METB6
AccessioniPrimary (citable) accession number: A7I7B2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3