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Protein

Catalase-peroxidase

Gene

katG

Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei93 – 931Transition state stabilizerUniRule annotation
Active sitei97 – 971Proton acceptorUniRule annotation
Metal bindingi260 – 2601Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-979-MONOMER.

Protein family/group databases

PeroxiBasei6985. CMbCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Mboo_0959
OrganismiMethanoregula boonei (strain 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
Proteomesi
  • UP000002408 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Catalase-peroxidasePRO_0000354967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki96 ↔ 219Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-245)UniRule annotation
Cross-linki219 ↔ 245Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi456442.Mboo_0959.

Structurei

3D structure databases

ProteinModelPortaliA7I6W6.
SMRiA7I6W6. Positions 21-731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04487. Archaea.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7I6W6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDDSTCPVT GGADKQVTGR GQSYRDWWPN QPNLRVLSQH SPRSNPMGGE
60 70 80 90 100
FNYAEEFKKL DFAAVKADLR ALMTSSQEWW PADFGHYGPL FIRMAWHSAG
110 120 130 140 150
TYRTLDGRGG AGSGQQRFPP LNSWPDNVNL DKARRLLWPI KKKYGRKISW
160 170 180 190 200
ADLMILAGNV ALESMGFETF GFAGGRVDTW EPDEDVYWGS ENTWLGDKRY
210 220 230 240 250
SGDRKLENPL AAVQMGLIYV NPEGPNGKPD PVAAAKDIRE TFARMAMNDE
260 270 280 290 300
ETVALIAGGH SFGKTHGAGP ASHVGPEPEA APIEQQGLGW KSSFGTGKGG
310 320 330 340 350
DAIGSGLEVT WTSTPTKWSN NFFRILFSYE WELTKSPAGA YQWQPKDGAG
360 370 380 390 400
AGTIPDAHDK NKRRAPTMLT TDLSLRFDPV YEKISRHFYE NPDQLADAFA
410 420 430 440 450
RAWFKLTHRD MGPRTRYLGP EVPKEALIWQ DPIPAVNHTL IGPREITFLK
460 470 480 490 500
RKILASGLSI PELVLTAWAS ASTFRGSDKR GGANGARIRL APQKDWEVNE
510 520 530 540 550
PARLRKVLAV LEGIQQEFNK TATGGKKVSL ADLIVLAGCA GVWKAAKNGG
560 570 580 590 600
HKVTVPFTPG RMDATQEQTD VNSFAVLEPK ADGFRNYLKG PYAVSAEELL
610 620 630 640 650
VDKAQLLTLS APEMTVLIGG LRVIGATYGQ ATHGVFTTLP GALTNDFFTH
660 670 680 690 700
LLDMGTEWKP VAGNPDVFEG SDRKTGEPKW TGTRVDLIFG ANAQLRAIAE
710 720 730
VYASADGEEK FAQDFVAAWA KVMNLDRFDL AQK
Length:733
Mass (Da):80,523
Last modified:September 11, 2007 - v1
Checksum:i907E15C2961F1BAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS55477.1.
RefSeqiWP_012106502.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS55477; ABS55477; Mboo_0959.
GeneIDi5412136.
KEGGimbn:Mboo_0959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS55477.1.
RefSeqiWP_012106502.1. NC_009712.1.

3D structure databases

ProteinModelPortaliA7I6W6.
SMRiA7I6W6. Positions 21-731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi456442.Mboo_0959.

Protein family/group databases

PeroxiBasei6985. CMbCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS55477; ABS55477; Mboo_0959.
GeneIDi5412136.
KEGGimbn:Mboo_0959.

Phylogenomic databases

eggNOGiarCOG04487. Archaea.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-979-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8.

Entry informationi

Entry nameiKATG_METB6
AccessioniPrimary (citable) accession number: A7I6W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: September 11, 2007
Last modified: December 9, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.