A7I6S6 (SURE_METB6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Mboo_0919

Organism

Methanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]

Taxonomic identifier

456442 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Methanoregula

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	5'-nucleotidase surE HAMAP MF_00060		PRO_0000335298
Sites
	Metal binding	10	1	Divalent metal cation By similarity
	Metal binding	11	1	Divalent metal cation By similarity
	Metal binding	41	1	Divalent metal cation By similarity
	Metal binding	95	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7I6S6 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: CE5636D349746047	FASTA	260	27,591
	10 20 30 40 50 60 MRPAILLTND DGVNSLGIWA AYEALSPIAD VTVVAPATQQ SAVGRSISIF EPIRANRIKI 70 80 90 100 110 120 NGNPAWAVGG KPTDAAIIGL YALKLAPALV VSGINIGENL SYESIMTSGT VGAALEAANQ 130 140 150 160 170 180 GTKGIAFSLQ VEDQGDKFDD PGQSAQSFDA AKKVVRDVVE RVLASGFPPA ADVINVNIPS 190 200 210 220 230 240 TIKGGYEVTH LARKLFHTGV EKRLDPRGRP YFWINGPLLE DAEEGTDVHA VRKGNVSITP 250 260 ITLDCTARTA DEDTKKIFLK

References

[1]

"Complete sequence of Candidatus Methanoregula boonei 6A8." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 6A8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000780 Genomic DNA. Translation: ABS55437.1.
RefSeq	YP_001404080.1. NC_009712.1.
3D structure databases
ProteinModelPortal	A7I6S6.
ModBase	Search...
Protein-protein interaction databases
STRING	A7I6S6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5410084.
GenomeReviews	Gene locus Mboo_0919 in contig CP000780_GR.
KEGG	mbn:Mboo_0919.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05083.
HOGENOM	HBG600532.
OMA	NGFYYVN.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	CMET456442:MBOO_0919-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_METB6

Accession

Primary (citable) accession number: A7I6S6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	September 11, 2007
Last modified:	November 16, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program