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Protein

Argininosuccinate lyase

Gene

argH

Organism
Methanoregula boonei (strain 6A8)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-753-MONOMER.
UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Mboo_0739Imported
OrganismiMethanoregula boonei (strain 6A8)Imported
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
Proteomesi
  • UP000002408 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_0739.

Structurei

3D structure databases

ProteinModelPortaliA7I696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 284206Lyase_1InterPro annotationAdd
BLAST
Domaini347 – 42074ASL_C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01748. Archaea.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiGRGKMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.

Sequencei

Sequence statusi: Complete.

A7I696-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLSSMRSD RCIADADVLV DIAHVLMLER QKIISTDTAK QLLPALLELN
60 70 80 90 100
SEGVPEEVFD DRFEDVHAGI ETLLIGAVGA DVGGRMHMGR SRNDEVATCI
110 120 130 140 150
RFKLREDLLK QLAALLKVRE VLVTLAEQHR ESVMPGFTHM QHAQPTTLAH
160 170 180 190 200
HLLAYEQQFT RDFDRLRDAY ARVNLCPLGA AAFASTGYPI DREYTAKLLA
210 220 230 240 250
FDGPVVNTMD AVATRDFALE TLADLSILMA NVSRLCEEMV IWSTSFVKFV
260 270 280 290 300
VLDDAFCSTS SIMPQKKNPD TAEIMRAKTG SVFGAYTGAL MTVKGLPMSY
310 320 330 340 350
NRDLQELTPN IWRGMRDAKE SLRLLIDMLS SATFDTERMK EEAGKGFSTA
360 370 380 390 400
TELADTLVRD YGLPFRMAHN IVGRAVQKGS LSLEMLEAAA KELDVGISFT
410 420 430 440 450
AKGLTQDQID KALDVTHSVE VRRATGGPAP FATKIAIADR KKLLDTDSVF
460 470
IDERLAKIAK AKEDLISDAR RLVA
Length:474
Mass (Da):52,448
Last modified:September 11, 2007 - v1
Checksum:i8528FCEACC3A943F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS55257.1.

Genome annotation databases

EnsemblBacteriaiABS55257; ABS55257; Mboo_0739.
KEGGimbn:Mboo_0739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA. Translation: ABS55257.1.

3D structure databases

ProteinModelPortaliA7I696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi456442.Mboo_0739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS55257; ABS55257; Mboo_0739.
KEGGimbn:Mboo_0739.

Phylogenomic databases

eggNOGiarCOG01748. Archaea.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiGRGKMER.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.
BioCyciMBOO456442:GH2T-753-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8Imported.

Entry informationi

Entry nameiA7I696_METB6
AccessioniPrimary (citable) accession number: A7I696
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 6, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.