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A7I5N0

- AMPPA_METB6

UniProt

A7I5N0 - AMPPA_METB6

Protein

AMP phosphorylase

Gene

Mboo_0523

Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

    Catalytic activityi

    AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei170 – 1701AMP; via amide nitrogenUniRule annotation
    Binding sitei205 – 2051AMP; via amide nitrogenUniRule annotation
    Active sitei258 – 2581Proton donorUniRule annotation
    Binding sitei266 – 2661AMPUniRule annotation
    Binding sitei290 – 2901AMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi196 – 2016AMPUniRule annotation

    GO - Molecular functioni

    1. AMP binding Source: UniProtKB-HAMAP
    2. phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
    3. pyrimidine nucleobase metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMBOO456442:GH2T-534-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
    Short name:
    AMPpaseUniRule annotation
    Alternative name(s):
    Nucleoside monophosphate phosphorylaseUniRule annotation
    Short name:
    NMP phosphorylaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Mboo_0523
    OrganismiMethanoregula boonei (strain 6A8)
    Taxonomic identifieri456442 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
    ProteomesiUP000002408: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508AMP phosphorylasePRO_0000314728Add
    BLAST

    Proteomic databases

    PRIDEiA7I5N0.

    Interactioni

    Protein-protein interaction databases

    STRINGi456442.Mboo_0523.

    Structurei

    3D structure databases

    ProteinModelPortaliA7I5N0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiESVPGFH.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_02132. AMP_phosphorylase.
    InterProiIPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7I5N0-1 [UniParc]FASTAAdd to Basket

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    MKYSVRILDI ATRSGILLNY LDARNIGVLD GDRVQLINPK NSLAVTAVVT    50
    TTSTLEGQGT AGVYRGTNRR LNLTEGEEIE IREADRPASL DFIKKKMDGG 100
    RLTKEETLTI IKDVVNDEIS AAELTAFITA SYINPLDMEE VEHLTRAMVE 150
    TGERIKFASR PIVDKHSIGG VPGNKISLLV VPIIAASGLK IPKTSSRAIT 200
    GAGGTADLME VLANVEFSAR EVQEMTEKVG GTIVWGGATN IAPADDRIIL 250
    QEYPFKIDAR GQMLASVMAK KYAVGANLVV IDIPVGSHTK VPTVQEGRKL 300
    AREFIELGER LGMKVECALT YGDIPVGYSI GPNLEVREAL RVLEGATEPN 350
    SFIQKSVSLA GIALEMSGKA ARGTGAQMAQ DILSSGKALE KFRQIIEIQG 400
    GDPKVKSEDI LPGEHQFVVN APASGYIVEM NNVSLITLAR LAGAPHDRGA 450
    GILLHAKKGT LIKAGEPLFT IYAEREWRLQ KAVEEGRHLV PVLVEGMLLD 500
    RVPSQSEV 508
    Length:508
    Mass (Da):54,775
    Last modified:September 11, 2007 - v1
    Checksum:iD9525886ED2DB7AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000780 Genomic DNA. Translation: ABS55041.1.
    RefSeqiYP_001403684.1. NC_009712.1.

    Genome annotation databases

    EnsemblBacteriaiABS55041; ABS55041; Mboo_0523.
    GeneIDi5410844.
    KEGGimbn:Mboo_0523.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000780 Genomic DNA. Translation: ABS55041.1 .
    RefSeqi YP_001403684.1. NC_009712.1.

    3D structure databases

    ProteinModelPortali A7I5N0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 456442.Mboo_0523.

    Proteomic databases

    PRIDEi A7I5N0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS55041 ; ABS55041 ; Mboo_0523 .
    GeneIDi 5410844.
    KEGGi mbn:Mboo_0523.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi ESVPGFH.

    Enzyme and pathway databases

    BioCyci MBOO456442:GH2T-534-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_02132. AMP_phosphorylase.
    InterProi IPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 6A8.

    Entry informationi

    Entry nameiAMPPA_METB6
    AccessioniPrimary (citable) accession number: A7I5N0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3