A7I5N0 (TYPH_METB6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Mboo_0523

Organism

Methanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]

Taxonomic identifier

456442 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanoregulaceae › Methanoregula › Methanoregula boonei

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314728

Sequences

	Sequence		Length	Mass (Da)
	A7I5N0 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: D9525886ED2DB7AE	FASTA	508	54,775
	10 20 30 40 50 60 MKYSVRILDI ATRSGILLNY LDARNIGVLD GDRVQLINPK NSLAVTAVVT TTSTLEGQGT 70 80 90 100 110 120 AGVYRGTNRR LNLTEGEEIE IREADRPASL DFIKKKMDGG RLTKEETLTI IKDVVNDEIS 130 140 150 160 170 180 AAELTAFITA SYINPLDMEE VEHLTRAMVE TGERIKFASR PIVDKHSIGG VPGNKISLLV 190 200 210 220 230 240 VPIIAASGLK IPKTSSRAIT GAGGTADLME VLANVEFSAR EVQEMTEKVG GTIVWGGATN 250 260 270 280 290 300 IAPADDRIIL QEYPFKIDAR GQMLASVMAK KYAVGANLVV IDIPVGSHTK VPTVQEGRKL 310 320 330 340 350 360 AREFIELGER LGMKVECALT YGDIPVGYSI GPNLEVREAL RVLEGATEPN SFIQKSVSLA 370 380 390 400 410 420 GIALEMSGKA ARGTGAQMAQ DILSSGKALE KFRQIIEIQG GDPKVKSEDI LPGEHQFVVN 430 440 450 460 470 480 APASGYIVEM NNVSLITLAR LAGAPHDRGA GILLHAKKGT LIKAGEPLFT IYAEREWRLQ 490 500 KAVEEGRHLV PVLVEGMLLD RVPSQSEV

References

[1]

"Complete sequence of Candidatus Methanoregula boonei 6A8." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 6A8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000780 Genomic DNA. Translation: ABS55041.1.
RefSeq	YP_001403684.1. NC_009712.1.
3D structure databases
ProteinModelPortal	A7I5N0.
ModBase	Search...
Protein-protein interaction databases
STRING	456442.Mboo_0523.
Proteomic databases
PRIDE	A7I5N0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS55041; ABS55041; Mboo_0523.
GeneID	5410844.
KEGG	mbn:Mboo_0523.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MBOO456442:GH2T-576-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METB6

Accession

Primary (citable) accession number: A7I5N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program