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A7I5N0

- AMPPA_METB6

UniProt

A7I5N0 - AMPPA_METB6

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Protein

AMP phosphorylase

Gene

Mboo_0523

Organism
Methanoregula boonei (strain 6A8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei170 – 1701AMP; via amide nitrogenUniRule annotation
Binding sitei205 – 2051AMP; via amide nitrogenUniRule annotation
Active sitei258 – 2581Proton donorUniRule annotation
Binding sitei266 – 2661AMPUniRule annotation
Binding sitei290 – 2901AMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 2016AMPUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: InterPro

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
  3. pyrimidine nucleobase metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMBOO456442:GH2T-534-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Mboo_0523
OrganismiMethanoregula boonei (strain 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
ProteomesiUP000002408: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508AMP phosphorylasePRO_0000314728Add
BLAST

Proteomic databases

PRIDEiA7I5N0.

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_0523.

Structurei

3D structure databases

ProteinModelPortaliA7I5N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiESVPGFH.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7I5N0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYSVRILDI ATRSGILLNY LDARNIGVLD GDRVQLINPK NSLAVTAVVT
60 70 80 90 100
TTSTLEGQGT AGVYRGTNRR LNLTEGEEIE IREADRPASL DFIKKKMDGG
110 120 130 140 150
RLTKEETLTI IKDVVNDEIS AAELTAFITA SYINPLDMEE VEHLTRAMVE
160 170 180 190 200
TGERIKFASR PIVDKHSIGG VPGNKISLLV VPIIAASGLK IPKTSSRAIT
210 220 230 240 250
GAGGTADLME VLANVEFSAR EVQEMTEKVG GTIVWGGATN IAPADDRIIL
260 270 280 290 300
QEYPFKIDAR GQMLASVMAK KYAVGANLVV IDIPVGSHTK VPTVQEGRKL
310 320 330 340 350
AREFIELGER LGMKVECALT YGDIPVGYSI GPNLEVREAL RVLEGATEPN
360 370 380 390 400
SFIQKSVSLA GIALEMSGKA ARGTGAQMAQ DILSSGKALE KFRQIIEIQG
410 420 430 440 450
GDPKVKSEDI LPGEHQFVVN APASGYIVEM NNVSLITLAR LAGAPHDRGA
460 470 480 490 500
GILLHAKKGT LIKAGEPLFT IYAEREWRLQ KAVEEGRHLV PVLVEGMLLD

RVPSQSEV
Length:508
Mass (Da):54,775
Last modified:September 11, 2007 - v1
Checksum:iD9525886ED2DB7AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS55041.1.
RefSeqiYP_001403684.1. NC_009712.1.

Genome annotation databases

EnsemblBacteriaiABS55041; ABS55041; Mboo_0523.
GeneIDi5410844.
KEGGimbn:Mboo_0523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000780 Genomic DNA. Translation: ABS55041.1 .
RefSeqi YP_001403684.1. NC_009712.1.

3D structure databases

ProteinModelPortali A7I5N0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456442.Mboo_0523.

Proteomic databases

PRIDEi A7I5N0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS55041 ; ABS55041 ; Mboo_0523 .
GeneIDi 5410844.
KEGGi mbn:Mboo_0523.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi ESVPGFH.

Enzyme and pathway databases

BioCyci MBOO456442:GH2T-534-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_02132. AMP_phosphorylase.
InterProi IPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 6A8.

Entry informationi

Entry nameiAMPPA_METB6
AccessioniPrimary (citable) accession number: A7I5N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3