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A7I4Y2 (SYR_METB6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Mboo_0271
OrganismMethanoregula boonei (strain 6A8) [Complete proteome] [HAMAP]
Taxonomic identifier456442 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018059

Regions

Motif119 – 12911"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A7I4Y2 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 6A8B6FE19BC578D5

FASTA55862,056
        10         20         30         40         50         60 
MVVDTTAAIK RALSECTGLA EIPLVDGGEH ADLATTVAFA LAKTKKQAPV KIAQDVVAAL 

        70         80         90        100        110        120 
KNNRELSDLG VTVEAKGPYI NFVFGSAYVT AALKAAVQPG YGSFPAKESP RIVLEHTSAN 

       130        140        150        160        170        180 
PNGPLHVGHI RNSIIGDSLA RAFRKAGYPL EVEYYVNDMG RQIAIVTWGF DHLEHGQHES 

       190        200        210        220        230        240 
EKEDAHIARV YIAANREIEK DPGITKQVDK LMELVESGDP ETVKKFRREV SRCLDGFAVT 

       250        260        270        280        290        300 
LKNLNVKHDR FVWESDFVKN GDTKAVIAKI ENLPQATHEG TLLALDLAEF GFTNKYVMRR 

       310        320        330        340        350        360 
SDGTSVYAAR DLAFHTWKNQ NFDRAIDVLG ADHKLIGAQL QCTMQLLGEK APEIVHFEFV 

       370        380        390        400        410        420 
SLPEGSMSTR AGKFVSADEL IDEVTKRAFD EVTTRRPELD EATRRNIADS VARAGIRYDI 

       430        440        450        460        470        480 
VKISPEKSTV FDWKQALDFE RQSGPYIQYA HARACSILEK AGAFEECYDL ATEQEIILAK 

       490        500        510        520        530        540 
KIAKFPSVIE KVVTELRPHL LATYAHELAD TFNTFYHYEP VLKSEGEVRD RRLTLVKAVQ 

       550 
NTLQESLETL GIDAIHTM 

« Hide

References

[1]"Complete sequence of Candidatus Methanoregula boonei 6A8."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Meincke L., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Zinder S., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 6A8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000780 Genomic DNA. Translation: ABS54793.1.
RefSeqYP_001403436.1. NC_009712.1.

3D structure databases

ProteinModelPortalA7I4Y2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING456442.Mboo_0271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS54793; ABS54793; Mboo_0271.
GeneID5412224.
KEGGmbn:Mboo_0271.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMAMEHMGFG.

Enzyme and pathway databases

BioCycMBOO456442:GH2T-275-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_METB6
AccessionPrimary (citable) accession number: A7I4Y2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries