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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:CHAB381_1594
OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Taxonomic identifieri360107 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002407 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalUniRule annotationAdd BLAST21
Transmembranei66 – 86HelicalUniRule annotationAdd BLAST21
Transmembranei88 – 108HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei161 – 181HelicalUniRule annotationAdd BLAST21
Transmembranei193 – 213HelicalUniRule annotationAdd BLAST21
Transmembranei227 – 247HelicalUniRule annotationAdd BLAST21
Transmembranei257 – 277HelicalUniRule annotationAdd BLAST21
Transmembranei282 – 302HelicalUniRule annotationAdd BLAST21
Transmembranei331 – 351HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029561 – 354Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST354

Interactioni

Protein-protein interaction databases

STRINGi360107.CHAB381_1594.

Structurei

3D structure databases

SMRiA7I3M7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A7I3M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYFLYKILN INILNYITVR AGIAFFAAFF LTAFFMPRFI AWAKNKHANQ
60 70 80 90 100
PIYELAPQSH KAKNKTPTMG GIVFITATLL SSLLCSNLTN TFVIGGILCL
110 120 130 140 150
FGFSFIGFKD DYGKIAGHSN HAGMSPRKKF MYQIGLSFAL SIILFLFANL
160 170 180 190 200
SGEFFIPFYK YALFNLQFFA IFFWMLVITA SSNSVNLTDG LDGLASIPSI
210 220 230 240 250
FALVSLGIFV YLCGHSVFSA YLFLPKVVGV GELCVVIFAL IGAILGFLWY
260 270 280 290 300
NCYPAQVFMG DSGSLSVGAF IGYTGVVSKN EILLIIIGFV FVIETLSVIL
310 320 330 340 350
QVGSFKIRKK RIFLMAPIHH HFELKGWNEN KIIVRFWIIA LIANIIALTT

LKLR
Length:354
Mass (Da):39,498
Last modified:September 11, 2007 - v1
Checksum:i8C8B41FDCAAE367E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000776 Genomic DNA. Translation: ABS51312.1.
RefSeqiWP_012109423.1. NC_009714.1.

Genome annotation databases

EnsemblBacteriaiABS51312; ABS51312; CHAB381_1594.
KEGGicha:CHAB381_1594.

Similar proteinsi

Entry informationi

Entry nameiMRAY_CAMHC
AccessioniPrimary (citable) accession number: A7I3M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: June 7, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families