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Protein

dCTP deaminase

Gene

dcd

Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:CHAB381_1552
OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Taxonomic identifieri360107 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002407 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000097011 – 190dCTP deaminaseAdd BLAST190

Interactioni

Protein-protein interaction databases

STRINGi360107.CHAB381_1552.

Structurei

3D structure databases

ProteinModelPortaliA7I3J2.
SMRiA7I3J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
HOGENOMiHOG000228600.
KOiK01494.
OMAiGQLCLFR.
OrthoDBiPOG091H02A6.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiView protein in InterPro
IPR011962. dCTP_deaminase.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

A7I3J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKSDKWIR EQSIKNGMIT PFCEENMGVG VVSYGLSSYG YDIRVADEFK
60 70 80 90 100
IFTNVGGTVV DPKNFDEKNI VDFKGDVCIV PPNSFALART IEYFKMPRDV
110 120 130 140 150
LAICLGKSTY ARCGIIVNVT PFEPGFEGHI TIEISNTTPL PAKIYANEGI
160 170 180 190
AQVLFLQGDE ICEVSYADKK GKYQRQKGIT LPRILEGDKK
Length:190
Mass (Da):21,116
Last modified:September 11, 2007 - v1
Checksum:iE0655208BF263A0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000776 Genomic DNA. Translation: ABS51590.1.
RefSeqiWP_012109388.1. NC_009714.1.

Genome annotation databases

EnsemblBacteriaiABS51590; ABS51590; CHAB381_1552.
KEGGicha:CHAB381_1552.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDCD_CAMHC
AccessioniPrimary (citable) accession number: A7I3J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families