ID   A7I394_CAMHC            Unreviewed;       699 AA.
AC   A7I394;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 99.
DE   SubName: Full=Leukotoxin translocation ATP-binding protein LktB {ECO:0000313|EMBL:ABS50954.1};
DE            EC=3.6.3.43 {ECO:0000313|EMBL:ABS50954.1};
GN   OrderedLocusNames=CHAB381_1446 {ECO:0000313|EMBL:ABS50954.1};
OS   Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 /
OS   CH001A).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=360107 {ECO:0000313|EMBL:ABS50954.1, ECO:0000313|Proteomes:UP000002407};
RN   [1] {ECO:0000313|Proteomes:UP000002407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A
RC   {ECO:0000313|Proteomes:UP000002407};
RA   Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA   Mandrell R.E., Nelson K.E.;
RT   "Complete genome sequence of Campylobacter hominis ATCC BAA-381, a
RT   commensal isolated from the human gastrointestinal tract.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP000776; ABS50954.1; -; Genomic_DNA.
DR   RefSeq; WP_012109288.1; NC_009714.1.
DR   AlphaFoldDB; A7I394; -.
DR   STRING; 360107.CHAB381_1446; -.
DR   KEGG; cha:CHAB381_1446; -.
DR   eggNOG; COG2274; Bacteria.
DR   HOGENOM; CLU_000604_95_4_7; -.
DR   OrthoDB; 9760168at2; -.
DR   Proteomes; UP000002407; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030256; C:type I protein secretion system complex; IEA:InterPro.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:InterPro.
DR   GO; GO:0030253; P:protein secretion by the type I secretion system; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd18588; ABC_6TM_CyaB_HlyB_like; 1.
DR   Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR010132; ATPase_T1SS_HlyB.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005074; Peptidase_C39.
DR   InterPro; IPR039421; Type_1_exporter.
DR   NCBIfam; TIGR01846; type_I_sec_HlyB; 1.
DR   PANTHER; PTHR24221:SF658; ABC TRANSPORTER B FAMILY MEMBER 29, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF03412; Peptidase_C39; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS50990; PEPTIDASE_C39; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:ABS50954.1};
KW   Hydrolase {ECO:0000313|EMBL:ABS50954.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002407};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        258..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..115
FT                   /note="Peptidase C39"
FT                   /evidence="ECO:0000259|PROSITE:PS50990"
FT   DOMAIN          145..424
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50929"
FT   DOMAIN          457..692
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   699 AA;  78584 MW;  4A3B89AD9E77F57F CRC64;
     MRTALQALAL ITQINRIPFD SKEIINKFAL NTNEPSIDEL TRIAKYLEFK AKIKNISEIS
     KYKPPFIAQS KQNTYFVIFQ ILEDGSFLIY DGGSSLKKIN KDEMNEISNS KIIVLAHKAL
     NSQVKFGFAW FYKKMLKFKF IIFEVLLASF IMQLFGLVTP LFTQVVLDKV LTHHSISTLN
     VIAVAFFAVI IFEMLLSLTR NYIFAHTTTK IDAQLGSELF LHLLLLPMTY FENRKVGNIA
     ARVRELDSIR DFIANKSVTV LLDLLFSFVF VIMMLLYSVK LTLIAIAFVS VIALIYFFIT
     PMLRARLNDK FEMGARSNSY LIESITGMQT VKSLAIEGGM QRNWEDYLAK YVKSSFNLSN
     LSNIASGFAN ALSKLMTLSI LYFGVGLVIE GKLSVGQLIA FQMFAGQFAS PVMRLVGLWN
     EFQQAIISVD KLGDILNTPT EQTTNKPISL NKVRGEIKFE NVSFRYNPGS NLVLKNLSFK
     IDANKSVGIV GKSGSGKSTI TKLIERLYLQ NDGAIYIDDI DIRHLNPYIL RQNIGVVLQE
     NYLFSGTIRE NISYAKADAS MDEIIKVAKI SGAHDFIKEL SSGYDTIVGE RGSSLSGGQK
     QRIAIARAII SNPKILIFDE ATSALDYESE KAITENLNKI KENRTFIIIA HRLSTIRNCD
     EIIVIDKGEI KERGSHDELV AKNGYYKKLL DAQAGLNHV
//